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Aspergillosis - PubMed

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Last Updated: 06 June 2022

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Cytokine response as a biomarker for early diagnosis and outcome prediction of stem cell transplant recipients and acute leukemia patients with invasive aspergillosis.

"We wanted to investigate the role of serum cytokine expression in invasive aspergillosis diagnosis and outcome prediction in hematologic patients," the author says. The serum cytokines were prospectively collected from all consecutive patients with hematologic malignances at IA diagnosis and compared to control patients matched by center, age, baseline disease, and therapeutic regimen in this multicenter research. On day 0 of IA patients with IA were markedly elevated in patients with IA relative to controls, even in those who were neutropenic. IA diagnosis's high IL6 levels are correlated with poor outcomes. ".

Source link: https://doi.org/10.1093/mmy/myac038


Autopsy study of fatal invasive pulmonary aspergillosis: Often undiagnosed premortem.

"Invasive aspergillosis is a common complication among immunocompromised and critically ill patients, but it is difficult to determine. We wanted to know how often patients go undiagnosed and how to recognize the presenting medical and radiologic characteristics associated with fatal IA. We investigated cases of fatal IA confirmed at autopsy at a tertiary academic hospital between 1999 and 2019. In 97% of cases, 46% were restricted to the lungs, and 51% had concomitant extrapulmonary involvement. In 85 percent, immunosuppressants were present in 85%. In 61% of cases, diagnostic bronchoscopy was performed, producing aspergillus in 63% of those cases by either bronchoalveolar lavage, bronchial washings, or transbronchial biopsy cultures. In 64%, either a respiratory coinfection or other systemic coinfection was suspected. In only 27% of fatal IA cases found at autopsy, clinicians correctly identified IA as the cause of death in only 27 percent of fatal IA cases identified at autopsy. ".

Source link: https://doi.org/10.1016/j.rmed.2022.106882


Therapeutic Potential of Green Synthesized Gold Nanoparticles Using Extract of Leptadenia hastata against Invasive Pulmonary Aspergillosis.

"We investigated the therapeutic value of green synthesized gold nanoparticles produced using ethanolic leaf extract of Leptadenia hastata against invasive pulmonary aspergillosis in mice in this research. " Using a well-established IPA mouse strain, the in vivo activity of LH-AuNPs against IPA was investigated in vivo. With MIC 64 u00b5g/mL, the fungus-resistant activity against Aspergillus fumigatus was diminished by 30% in comparison to the control. Interestingly, LH-AuNPs did not have any cytotoxicity on cultured primary bone marrow stem cells or a A549 human lung cell line in vitro at MIC concentration, despite MIC concentration. Despite no in vivo cytotoxicity, LH-AuNP-treated IPA mice treated with LH-AuNPs showed significant lung tissue repair without any in vivo cytotoxicity. The lung's LH-AuNPs administration showed significant reduction of fungal burden and gliotoxin production. In conclusion, our results demonstrate LH-AuNPs as a novel nanoparticle therapy for IPA. ".

Source link: https://doi.org/10.3390/jof8050442


Serum Cytokines Usefulness for Understanding the Pathology in Allergic Bronchopulmonary Aspergillosis and Chronic Pulmonary Aspergillosis.

"Allergic bronchopulmonary aspergillosis and chronic pulmonary aspergillosis are two common fungal infections caused by Aspergillus species. At Nagasaki University Hospital between January 2003 and December 2018, we compared the various serum cytokine levels among healthy subjects and patients diagnosed with asthma, ABPA, or CPA. Patients with ABPA were significantly higher in patients with ABPA than those with CPA, and interleukin-5, IL-33, and tumor necrosis factor factors were significantly higher in patients with CPA than those with asthma.

Source link: https://doi.org/10.3390/jof8050436


Monoclonal Antibodies and Invasive Aspergillosis: Diagnostic and Therapeutic Perspectives.

"Invasive aspergillosis is a life-threatening fungal disease that causes high morbidity and mortality in immunosuppressed patients. " In addition, many high-risk patients receive an empirical therapy or a prolonged therapy of high-priced antifungal agents, often resulting in unnecessary adverse effects and a high risk of drug resistance. Monoclonal antibodies with high specificity in recognizing the corresponding antigen may have the ability to develop diagnostic procedures and be the basis for novel IA treatments. This report summarizes the up-to-date application of mAb-based techniques in assisting IA diagnosis and therapy.

Source link: https://doi.org/10.3390/ijms23105563


Elevated Rates of Ventilator-Associated Pneumonia and COVID-19 Associated Pulmonary Aspergillosis in Critically Ill Patients with SARS-CoV2 Infection in the Second Wave: A Retrospective Chart Review.

"The prevalence of ventilator-associated pneumonia in critically ill COVID-19 patients has been reported in a range of 7. 6% to 86%. " The prevalence of invasive pulmonary aspergillosis in this cohort has ranged from 4% to 30%. In a large university hospital, a retrospective chart review of 276 patients who were admitted to intensive care was undertaken. COVID-19 Wave 1, COVID-19 Wave 2, influenza, and community-acquired pneumonia were among the four groups tested: COVID-19 Wave 1, COVID-19 Wave 2, influenza, and community-acquired pneumonia. According to the respective statistics, respiratory-associated pneumonia in COVID-19 Wave 2, influenza, and community-acquired pneumonia were 5. 45%, 27. 40%, 17. 67%, and 3. 4 percent. In the second wave of COVID-19, a significantly higher risk of ventilator-associated pneumonia and invasive pulmonary aspergillosis was discovered in comparison to the first. All four groups indicated that increased steroid use was a significant risk factor for ventilator-associated pneumonia and chronic pulmonary aspergillosis.

Source link: https://doi.org/10.3390/antibiotics11050632


Incorporating the Detection of Single Nucleotide Polymorphisms Associated With Invasive Aspergillosis Into the Clinic.

"Exposure to fungi is inevitable, but only a small number of patients with a high risk of invasive aspergillosis develop invasive aspergillosis. " While timing of exposure in relation to immune status, environmental, and occupational causes can influence the likelihood of developing IA, genetic variations in the host's genetic code have been attributed to an elevated risk of developing IA. Screening for SNPs in genes closely associated with IA may be included in the clinical study on admission or post-allogeneic stem cell transplantation to augment fungal biomarker screening. We're approaching a time when we will be able to accurately predict the risk of IA in the haematology patient by combining clinical and genetic risk with mycologic findings, and we'll be able to stratify each individual's care.

Source link: https://doi.org/10.3389/fcimb.2022.860779


Fatal invasive aspergillosis in a child with chronic granulomatous disease.

"We explore an eight-year-old boy with persistent granulomatous disease, cerebral venous sinus thrombosis, and unusual skin lesions caused by Aspergillus fumigatus in this story. In children with invasive fungal infections, particularly those involving the central nervous system, early diagnosis of invasive aspergillosis should be considered early.

Source link: https://doi.org/10.12968/jowc.2022.31.5.427

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions