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"Objective: The aim of this research was to investigate the correlation between CT findings of invasive pulmonary aspergillosis and neutrophils level. " Methods: This retrospective review included patients diagnosed with invasive pulmonary aspergillosis by computed tomography at Siriraj Hospital from May 2006 to May 2010. Results: Out of the 43 patients that were accepted, 14 patients were categorized into group I, while 29 patients were referred to group II. Pulmillosis' most common CT finding was pulmonary nodules, followed by CT halo sign and consolidation. Consolidation and central cavity respectively, and CT finding that showed significantly higher rates in patients in group I and group II were patients. Conclusion: Consolidation was the CT finding that was most commonly found in patients with neutrophils 500 cell/mm3, and the central cavity was the most common in invasive pulmonary aspergillosis with neutrophils 500 cell/mm3 with non-specific distribution.
"Abstract The invasive aspergillosis (AKA) is a common fungal disease in immunocompromized people. " Toll-like receptor and dectin-1 genetic polymorphisms have been shown in several studies to modify signaling pathways, thus increasing an individual's susceptibility to invasive aspergillosis. Moreover, our literature review found a strong correlation between polymorphisms in the genes that code toll-like receptors and dectin-1 and invasive aspergillosis. "Toll-like receptor and dectin-1 genetic polymorphisms, as well as invasive aspergillosis susceptibility," should be investigated more thoroughly.
Source link: https://doi.org/10.1590/0037-8682-0314-2018
"Aspergillosis is an infection that causes saprophytic fungus, which typically occurs in immunosuppressed individuals, but has also been found in immunocompetent patients. " In the literature, there have been no cases of invasive aspergillosis related to cocaine use. A satisfactory esthetic result was achieved after a Nasal reconstruction with a skin graft over a silicone prosthesis.
Source link: https://doi.org/10.1590/0037-8682-0086-2014
"Infections caused by A. fumigatus result in a widespread inflammation response that can cause respiratory disease and can be lethal in immunocompromized individuals. Unexplored, the role of EVs as a means of modulating an efficient response to A. fumigatus infections is yet to be explored. Here we investigate the use of EVs derived from A. fumigatus as an immunization agent in order to promote a more robust immune response to A. fumigatus pulmonary disease. Male C57BL/6 mice were immunized with two doses of EVs and A. fumigatus in order to investigate the issue. Noteworthy, immunization with EVs, associating with low doses of Amphotericin B therapy, saved half of mice infected with A. fumigatus from lethal fungal pneumonia. "The current research shows a new role for A. fumigatus EVs as host inflammatory response modulators, implying their use as immunization agents. ".
Source link: https://doi.org/10.3389/fcimb.2022.898619
"Gold nanoparticles are widely used in the biomedical field for the treatment of several disorders, including cancer, inflammatory disorders, and immune system disorders, due to their distinctive physicochemical characteristics. " In this research, we investigated the therapeutic value of green synthesized gold nanoparticles made from ethanolic leaf extract of Leptadenia hastata against infectious pulmonary aspergillosis in mice. The in vitro activity of LH-AuNPs against IPA was investigated using a well-established IPA mouse strain. With MIC 64 & 505g/mL, a LH-AuNPs treated antifungal activity against Aspergillus fumigatus, reducing A. fumigatus radial expansion by 30% compared to the control. Interestingly, LH-AuNPs did not exhibit any cytotoxicity on cultured primary bone marrow stem cells or an A549 human lung cell line in vitro at MIC concentration. IPA mice treated with LH-AuNPs had dramatic lung tissue repair in vivo, without any in vivo cytotoxicity. "The LH-AuNPs administration demonstrated significant reductions in fungal burden and gliotoxin production in the lung. ".
Source link: https://doi.org/10.3390/jof8050442
"Allergic bronchopulmonary aspergillosis and chronic pulmonary aspergillosis are common fungal infections caused by Aspergillus species. " At Nagasaki University Hospital between January 2003 and December 2018, we compared the various serum cytokine levels among healthy subjects and patients diagnosed with asthma, ABPA, or CPA. Patients with ABPA were significantly higher in patients with ABPA than in those with CPA, and Interleukin -5 scores were significantly higher in patients with ABPA than in those with CPA, and IL-33 and tumor necrosis factor scores were significantly higher in patients with CPA than those with asthma. ".
Source link: https://doi.org/10.3390/jof8050436
"Invasive aspergillosis is a life-threatening fungal disease that causes elevated morbidity and mortality in immunosuppressed patients. " In addition, many high-risk patients receive an empirical therapy or a long-term therapy of high-priced antifungal agents, resulting in unnecessary adverse effects and a high risk of drug resistance in addition. Monoclonal antibodies with high specificity in targeting the corresponding antigen may have the ability to analyze diagnostic procedures and provide the basis for novel IA treatments. ".
Source link: https://doi.org/10.3390/ijms23105563
"The aim of this investigation is to compare clinical and imaging characteristics of COVID-19 patients with and without associated pulmonary asthmapergillosis. " Patients with respiratory aspergillosis in 105 chest CTs compared by two observers independently to 39 chest CTs of 13 CAPA patients. The following characteristics were evaluated: lung involvement, the most common pattern, and additional lung and chest findings. CAPA patients with COVID-19 patients without pulmonary aspergillosis were found older mean age compared to 63. 5 years compared to 63. 5 years. The time-dependent evolution of consolidation and glass differed. Consolidation was associated with CAPA in early COVID-19 disease, but ground glass was less common. Regardless of the time of day, bronchial wall thickening was observed more often in CAPA patients. Conclusions: CAPA patients exhibited a tendency for consolidation in early COVID-19 disease. CAPA is a medical disorder that was related to increased patient age and fractured Bronchial wall thickening.
Source link: https://doi.org/10.3390/diagnostics12051201
"The prevalence of ventilator-associated pneumonia in critically ill COVID-19 patients has been ranging from 7. 6% to 86%. " The incidence of invasive pulmonary aspergillosis in this cohort has ranged from 4% to 30%. In a large university hospital, we undertook a retrospective chart review of 276 patients who were admitted to intensive care. According to the study, the incidence of ventilator-associated pneumonia in COVID-19 Wave 1, influenza, and community-acquired pneumonia was 5. 45%, 27. 40%, 16. 67%, and 3. 4 percent, respectively. 0%, 9. 5 percent, 13. 33%, and 6. 82% were respectively the rate of invasive pulmonary aspergillosis. In the second wave of COVID-19, a significant rise in ventilator-associated pneumonia and invasive pulmonary aspergillosis was noted in contrast to the first. "Both of these groups, increased steroid use was a risk factor for ventilator-associated pneumonia and invasive pulmonary aspergillosis. ".
Source link: https://doi.org/10.3390/antibiotics11050632
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