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Aspergillosis - Crossref

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Last Updated: 06 June 2022

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Successful Treatment with Methylprednisolone Pulse Therapy for a Life-Threatening Pulmonary Insufficiency in a Patient with Chronic Granulomatous Disease following Pulmonary Invasive Aspergillosis and Burkholderia cepacia Infection

"A 14-year-old boy with X-linked chronic granulomatous disease had severe invasive pulmonary aspergillosis," the author wrote. Hebronchoalveolar lavage Burkholderia cepacia was isolated from his bronchoalveolar tero. A methylprednisolone pulse therapy was started in Then, along with the use of appropriate antibiotics and adequate amounts of amphotericin B. Hence, a methylprednisolone pulse therapy with appropriate antimicrobial agents seems to be helpful for severe pulmonary insufficiency in these patients. ".

Source link: https://doi.org/10.1159/000029435


Allergic Bronchopulmonary Aspergillosis due to Aspergillus niger without Bronchial Asthma

"Peripheral blood eosinophilia and elevated serum IgE were found," a report. Aspergillus n. . . . was cultured on her sputum repeatedly, but A. fumigatus was not detected. Aspergillus antigen positive results from urgent skin test and a specific IgE to Aspergillus antigen were positive. A. n. . . . antigen antibody was identified against A. n. . . . antigen but not against A. fumigatus antigen. This case was diagnosed as allergic bronchopulmonary aspergillosis without bronchial asthma due to A. n. . . . , an organism that is unusually present in ABPA. ".

Source link: https://doi.org/10.1159/000029392


Cerebral Aspergillosis in Children

"The first case was a patient with a history of subcutaneous ependymoma, which revealed a new escalating mass on a control CT scan. " The initiation of brain tumor recidiva was suspected, but an Aspergillus granuloma was discovered on the tumor bed. Both other cases were found in patients undergoing transplantation: one patient had multiple cerebral lesions after a renal transplant, and the other, after a bone marrow transplant, suffered a rhinocerebral aspergillosis.

Source link: https://doi.org/10.1159/000028974


Cytokine response as a biomarker for early diagnosis and outcome prediction of stem cell transplant recipients and acute leukemia patients with invasive aspergillosis

"Abstract We investigated the role of serum cytokine expression in invasive aspergillosis diagnosis and outcome prediction in hematologic patients. In this multicenter research, serum cytokines were prospectively recruited from all consecutive patients with hematologic malignances at IA diagnosis, as well as control patients matched by center, age, baseline disease, and therapeutic regimen. Even in patients with IA who were neutropenic, serum levels of IL6 and IL10 cytokines were significantly higher on day 0 in patients with IA. According to IL6 and IL10, IA is expected in an area under the ROC curve of 0. 74 and 0. 64, respectively. ".

Source link: https://doi.org/10.1093/mmy/myac038


Cytokine Profile of Invasive Pulmonary Aspergillosis in Severe COVID-19 and Possible Therapeutic Targets

"During the SARS-CoV-2 pandemic, a higher risk of invasive pulmonary aspergillosis was found in patients affected by Coronavirus disease 2019, leading to the delineation of a new entity named COVID-19 associated pulmonary aspergillosis. We also sought to focus on IPA's lesser-known and less well-known risk factors for opium suppression in COVID-19 patients, which are related to the key causes of immune suppression, both viral-mediated and iatrogenic, including medications currently approved for COVID-19. ".

Source link: https://doi.org/10.3390/diagnostics12061364


Pre-Exposure With Extracellular Vesicles From Aspergillus fumigatus Attenuates Inflammatory Response and Enhances Fungal Clearance in a Murine Model Pulmonary Aspergillosis

"Infections caused by A. fumigatus result in a heightened immune response that may develop into respiratory disease and may be lethal in immunocompromized individuals. " Unexplored, the role of EVs as a tool for triggering an efficient response to A. fumigatus infections remains unexplored. Here we investigate the use of EVs obtained from A. fumigatus as an immunization device to promote a more robust immune response to A. fumigatus pulmonary disease. Male C57BL/6 mice were immunized with two doses of EVs and contaminated with A. fumigatus in order to investigate the cause. Noteworthy, immunization with EVs, as a result of low doses of Amphotericin B therapy, infected with A. fumigatus, lethal fungal pneumonia, killed half of mice. Therefore, the current report shows a new role for A. fumigatus EVs as host response modulators, suggesting their use as immunizing agents. ".

Source link: https://doi.org/10.3389/fcimb.2022.898619


Invasive Sino-orbital Aspergillosis in an Immunocompetent Host selecting a Surgical Approach: Changing Trend

"ABSTRACT ACT is a rare medical disorder" in an immunocompetent host. A 48-year-old female patient presented with 6 months of nontender swelling over the left maxilla, 5 months of left-sided nasal blockage, and 2 months of left orbital proptosis in the United States.

Source link: https://doi.org/10.5005/jp-journals-10013-1163


Rhino-orbital Aspergillosis: Changing Trends in the Management?

"Abstract Purpose Purpose" is a verb that means to analyze oral voriconazole's results following an optimal management strategy for invasive sino-orbital aspergillosis. Methods It was a prospective review in which in all immunocompetent cases with a definitive histopathological diagnosis of invasive sino-orbital aspergillosis were included from a period from Jan 2007 to Dec 2009. The individuals in each group were exposed to the group's treatment regimen if it was approved. In two cases, respiratory disease was seen in two cases, and recurrence was observed in 1 case. Voriconazole, according to our report, was shown to significantly improve the results of sino-orbital aspergillosis.

Source link: https://doi.org/10.5005/jp-journals-10013-1052


Invasive Sino-aspergillosis in Immunocompetent Individuals: Atypical Presentations

In such situations, invasive aspergillosis of the orbit and paranasal sinuses in immunocompetent individuals with no nasal signs were present, and it was necessary to investigate the role of voriconazole in those situations. " For six months, the patients with sphenoid sinus involvement received 2. 5 gm of intravenous Amphotericin B and oral itraconazole in a dose of ten mg/kg/day for six months, with sphenoid sinus involvement. Two to six months ago, the cases where there were less likely of intracranial involvement or in the cases that refused for intravenous Amphotericin B were both initiated on voriconazole 200 mg twice a day for six to twelve months were started on voriconazole 200 mg twice a day for six to twelve months. Conclusions We found isolated sphenoid sinus involvement in ten cases, isolated maxillary sinus involvement in 2 cases, and isolated orbital involvement 1 in ten cases. Conclusions This report examined the atypical findings of invasive aspergillosis in immunocompetent individuals and the high degree of mistrust required to diagnose this condition. ".

Source link: https://doi.org/10.5005/jp-journals-10013-1006


How Has the Aspergillosis Case Fatality Rate Changed over the Last Two Decades in Spain?

"Background: Aspergillus causes high morbidity and mortality, particularly in at-risk populations. " In Spain, the aim of this research was to determine the incidence of aspergillosis in patients from 1997 to 2017. Methodology: A retrospective descriptive review was conducted with records of patients admitted to the National Health System with a diagnosis of aspergillosis. Principal findings: 32,960 aspergillosis inpatients were reported, 24. 5% of deaths were recorded, and 71% of the patients who died were men. In both cases, epidemic and pneumonia occurrence/association significantly raised case fatality rates. Patients with solid and/or hematological cancer have no greater mortality risk than those with pneumonia or influenza alone, with these two causes leading to the highest CFRs. "We also need studies that investigate the causes of death in order to minimize it, as well as those that examine the effects of COVID-19. ".

Source link: https://doi.org/10.3390/jof8060576

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions