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"Here, we investigate how BTK-mediated signaling links with gut microbiome. " Mice that are deficient in Btk were found to have small Peyer's Patches with reduced germinal center and IgA class-switched B cells. Despite Btk deficiency and somatic hypermutation frequency, IgH CDR3 sequencing revealed similar V gene diversity and somatic hypermutation frequency, but showed reduced CDR3 amino acid polarity, indicating potential qualitative differences in the gut plasma cell repertoire. As small intestinal IgA was low, and the IgA coating of commensal bacteria was reduced, and intestinal IgA was decreased. Overall, this report shows that BTK promotes normal intestinal IgA growth in response to commensals. ".
Source link: https://doi.org/10.3389/fimmu.2022.748284
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