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Arthritis - Crossref

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Last Updated: 10 June 2022

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Evaluation of Vitamin D and trace element level in sera of patients with Rheumatoid arthritis

"Results: When compared to the healthy individuals, the serum levels were significantly lower in the RA patients. " When compared to healthy control, serum levels of were significantly elevated in RA patients when compared to healthy controls, according to the analysis of results. Compared to healthy controls, the serum levels of were significantly reduced in RA patients when compared to healthy controls. Insufficiency is more common among patients with RA, and it may be one of the reasons leading to the development of rheumatoid arthritis.

Source link: https://doi.org/10.22317/imj.v6i1.1114


Novel Biomarkers, Diagnostic and Therapeutic Approach in Rheumatoid Arthritis Interstitial Lung Disease—A Narrative Review

"Rheumatoid arthritis is a systemic inflammatory disease that affects the joints symmetrically, contributing to progressive bone degeneration and eventually joint deformity. " In this research, we will explore the causes of RA interstitial lung disease, the pathogenesis of ILD in RA, as well as the therapeutic difficulties that may be related to this unique extra-articular manifestation. The intention is that finding biomarkers with high success characteristics would help researchers better understand the pathophysiology of RA-ILD and, in turn, lead to the creation of targeted therapies for this severe RA manifestation. ".

Source link: https://doi.org/10.3390/biomedicines10061367


Deep Learning-Based Computer-Aided Diagnosis of Rheumatoid Arthritis with Hand X-ray Images Conforming to Modified Total Sharp/van der Heijde Score

In hand X-ray photographs for preprocessing joint space narrowing in mTSS, we suggest not only an automated label system leveraging the You Only Look Once system to identify the joints of the two hands' joints, but also a joint classification system based on the severity of the mTSS-based disease. The window level is used to represent the clinician's processing procedure, the test results of the different carpal and finger bones of human vision are separated and integrated, and the resolution is increased or decreased to observe the model's accuracy. If it is used in clinical practice, we suggest that starting the one-hand X-ray imaging technique can enhance the sensitivity of the mTSS classification model in determining mild disease.

Source link: https://doi.org/10.3390/biomedicines10061355


Enhancing Prednisone-Based Arthritis Therapy with Targeted IL-27 Gene Delivery

"Glucocorticoids are often used to treat RA due to their strong anti-inflammatory and immunosuppressive properties. " We looked at the potential interaction of low-dose prednisone and gene delivery of an agent of promise and complementing effectiveness in RA, interleukin -27. U03b1 expression increased during inflammation, according to this analysis. The present research examined a IL-27 targeted at the C-terminus with a short peptide Lu2019 that binds the interleukin 6 receptor LUT161 receptor, which is upregulated during inflammation. We investigated whether the anti-inflammatory activity of prednisone could be enhanced in the presence of 27pL or 27pL as a therapy adjuvant" by concentrating on this specific model, IL-27pepL or 27pL.

Source link: https://doi.org/10.3390/bioengineering9060248


Effects of Hydroxychloroquine on Progression of Diabetic Retinopathy in Subjects with Rheumatoid Arthritis and Type 2 Diabetes Mellitus

"The primary aim was to determine the effect of hydroxychloroquine on the onset of Diabetic Retinopathy and disease progression. " As secondary goals in the Early Treatment Diabetic Retinopathy Study, two additional objectives, worsening of visual acuity and the establishment of clinically significant macular edema, were included on these charts. Methods: The retrospective review was based on medical records of all Rheumatoid Arthritis patients who had T2DM and were treated with hydroxychloroquine 400 mg OD or 200 mg BID and ophthalmologic care at an endocrinology clinic in India, up to a mean follow-up of 3. 5 years and matched subjects taking any other disease-modifying antirheumatic medications and pioglitazone, including a based on based on a based on medical records of a to atoid Arthritis patients who were treated with o a ota hemoglobo oe OD or 200 mg BID or 200 mg BID or 200 mg BID and received ophthalmologic clinic in India's and 3. 5 years and 3. 4 years and pharmacta modifying antirheuv. In the HCQ group, no new cases of DR were found, although 2 patients had developed DR in the pioglitazone group. Progression to moderate NPDR over 3. 5 years occurred in 2 out of 18 eyes in the HCQ group and 8 out of 14 eyes in the pioglitazone group, respectively, indicating significant relative risk reduction. In the HCQ group, mild NDPR to severe NPDR had progressed, while in the pioglitazone group, 2 eyes had progressed from mild NPDR to severe NPDR. None of the patients in either arm of the disease has diabetic macular oedema. Progression of DR from mild to moderate NPDR or severe NPDR may be slowed by HCQ. To establish the risk-benefit profiles of HCQ in T2DM, a large scale randomised prospective clinical trial is required.

Source link: https://doi.org/10.2174/1573399818666220118101320


Neck pain and related factors in patients with rheumatoid arthritis

"This research was designed to determine the incidence of neck pain in patients with rheumatoid arthritis patients and elucidate the causal causes. " Age, C7 sagittal vertical axis, upper cervical lesion, and endplate erosion were all factors associated with neck pain in patients with rheumatoid arthritis, according to the multivariate study. More than half of patients with rheumatoid arthritis suffer from neck pain, and neck pain impacts daily life and activities. Neck pain was correlated with upper cervical lesion and endplate erosion, raising the importance of radiological examination in patients with rheumatoid arthritis and neck pain. ".

Source link: https://doi.org/10.1093/mr/roac049


Relationship of Fatigue Severity with Disability, pain and Sleep Disturbance in Patients with Rheumatoid Arthritis and Osteoarthritis: A Cross-Sectional Study

"Objective: Fatigue is one of arthritis's most disabling signs. " This review was designed to investigate exhaustion in Osteoarthritis and Rheumatoid arthritis, as well as its relationship with pain, disability, and sleep disruption. To determine the intensity of exhaustion, the Fatigue Severity Scale questionnaire was used. Conclusion: Our study revealed that the osteoarthritis group had a strong but weak relationship with disability p-value 0. 001, pain p-value, and sleep disturbances p-value"; however, our analysis showed the osteoarthritis group had a significant but weak link with disability. p-value 0. 001, pain p-value, and sleep disruptions p-value are both significant but not significant.

Source link: https://doi.org/10.21649/akemu.v27i4.4892


The polygenic nature of rheumatoid arthritis

In the study, "Current breakthroughs in the genetic basis of rheumatoid arthritis were summarised. " The key role of the major histocompatibility complex and a shared epitope, as well as the contribution of non-HLA genes to resistance to RA was considered in terms of patient ethnicity and the disease's serological status. The GWAS' results for identifying candidate genes closely linked to RA risk were systematized, as well as some aspects of epigenetics.

Source link: https://doi.org/10.17816/ecogen17477-90


Genetic susceptibility to juvenile idiopathic arthritis in the Belarusian population: gene-gene interactions analysis

"GWASs identified a substantial number of candidate genes for juvenile idiopathic arthritis susceptibility. " Individual SNP results have limitations because the consequences of each substitution's influence may be too subtle to be determined, but their interactions may play a large role in disease susceptibility. The study included 118 patients with JIA and 202 controls. "A highly significant high-order interaction of five polymorphisms found in a Belarusian population's JIA genetic susceptibility. ".

Source link: https://doi.org/10.17816/ecogen17465-76


LCK and its related molecules as potential biomarkers in rheumatoid arthritis

"Abstract Background Rheumatoid arthritis is a form of systemic immune disease characterized by persistent joint disease. " Methods The Gene Expression Omnibus database contained three microarray datasets. The Gene Expression Omnibus database held the three microarray datasets. Next, we performed functional enrichment testing using the Gene Ontology and Kyoto Encyclopaedia of Genes and Genomes. Other bioinformatics protocols, such as proteinu2013web network analysis and establishment of miRNA-u2013hub gene networks and transcription factors u2013hub gene networks, are also performed, including proteinu2013protein interaction network analysis and establishment of miRNAu2013hub gene networks and transcription factors u2013hub gene networks and transcription factors, are also employed, including proteinu2013hub gene networks and transcription factors. In addition, we screened out has-miR-146a-5p, which is the miRNA with the largest number of hub genes among miRNA's miRNA networks, revealing the largest number of hub genes. Conclusions In summary, bioinformatics studies were used to identify DEGs in order to find potential biomarkers that may be related to RA. Our report may have ramifications and targeted therapy of RA in the future, and may have ramifications and targeted therapy of RA. ".

Source link: https://doi.org/10.21203/rs.3.rs-1470290/v2

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions