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Arthritis - ClinicalTrials.gov

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Last Updated: 10 June 2022

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Treatment Outcomes for Ankle Arthritis

"Bothete arthrodesis and arthroplasty are two common surgical procedures used to relieve pain and improve mobility. " The proposed research will investigate walking habits in patients and any difference in activity immediately before and after undergoing surgical intervention for ankle arthritis. The investigators propose a mobility outcome study involving up to 500 ankle osteoarthritis patients who will have corrective surgery. Methodology: The investigators suggest a mobility outcome study with a total of up to 500 ankle osteoarthritis patients before and after surgery during the three years of the study. Patients at the VA Puget Sound Health Care Center, Harborview Medical Center, Orthopedic + Fracture Specialists, Orthopaedic Associates of Michigan, and Twin Cities Orthopedic Patients with end stage ankle arthrosis will be recruited from patients who have been diagnosed with end-stage ankle arthritis, are physically fit, and between the ages of 18-80. After completing the questionnaires, participants will be able to wear the Stepwatch Activity Monitor around their ankle. The SAM will be worn around the subject's ankle for 14 days, and then the subject will return the monitor and activity log to the VA by visit or mail. The VA Puget Sound Health Care System in Seattle, WA, is where the Gait assessment takes place.

Source link: https://clinicaltrials.gov/ct2/show/NCT00391365


Advanced Therapeutics in Rheumatoid Arthritis (RA)

Nonsteroidal anti-inflammatory drugs, cyclooxygenase-2 specific inhibitors, corticosteroids, and disease-modifying anti-rheumatic drugs are among the conventional anti-rheumatic drugs used in Rheumatoid Arthritis therapy. " Tumour Necrosis Factor is often used to treat arthritis-related pain and inflammation. Retention is the biggest issue with TNFi and other advanced therapies in RA. "The Janus kinase inhibitor, another new drug in RA, has demonstrated similar effectiveness to TNFi therapy. ".

Source link: https://clinicaltrials.gov/ct2/show/NCT03976245


A MEDiterranean Diet in Rheumatoid Arthritis (MEDRA)

"Rheumatoid arthritis is a long-term inflammatory disease that commonly occurs in the hands, wrists, and feet's small joints, resulting in swelling, pain, and stiffness in the affected joints. " Currently, there is no drug that will cause complete remission of the disease among people with RA. Although diet is not part of the traditional treatment, numerous studies have shown the beneficial effects of certain diets on RA symptoms. In Ireland, the MEDRA report will investigate whether people with RA in Ireland will benefit from either a Mediterranean diet or the Healthy eating recommendations. This small scale survey will reveal useful information on whether people with RA in Ireland can adhere to a Mediterranean diet pattern and whether intervention will have a positive effect on the physical appearance and quality of life. ".

Source link: https://clinicaltrials.gov/ct2/show/NCT04262505


Meditation Effects on Brain Function in Rheumatoid Arthritis

"Before-intuitive thermal stimulation, participants will perform functional MRI using a perfusion-based arterial spin labeling system during noxious thermal stimulation to see if the meditation practices differentially affect neural function during noxious thermal stimulation. ".

Source link: https://clinicaltrials.gov/ct2/show/NCT03975595


Strategy to Prevent the Onset of Clinically-Apparent Rheumatoid Arthritis

"RA is a disease in which the immune system attacks the joints, resulting in joint inflammation and joint inflammation in joints, as well as swelling in joints" associated with RA as joint pain, stiffness, and swelling. Anti-CCP3 is a specific for RA and can predict the occurrence of RA in the future, especially if the level of anti-CCP3 is high. According to the investigators of this report, individuals with elevations of anti-CCP3 u22652 times the average have about a 50% risk of experiencing RA within 3 years. The aim of this study is to determine if treating HCQ in people with elevated levels of anti-CCP3 without joint inflammation will help avoid the development of RA in the future. This will be carried out by a 12-month course in HCQ in the prevention of clinically apparent RA at 36 months in patients at risk of future RA due to elevated titer elevations of anti-CCP3.

Source link: https://clinicaltrials.gov/ct2/show/NCT02603146


Weight Loss and Exercise for Communities With Arthritis in North Carolina

"The investigators found that, under optimal, highly monitored conditions, a diet-induced weight loss of 10% along with exercise was more effective at reducing pain than either intervention alone. " The diet-induced weight loss and exercise program was twice as effective at relieving pain as the investigators' previous long-term weight loss and exercise trials of knee OA. This research intends to develop and demonstrate the success of a systematic, affordable, cost-effective diet-induced weight loss and exercise intervention in both urban and rural settings that can reduce pain and improve other medical outcomes in knee OA patients. When compared to an attention control group, the key goal is to determine if a pragmatic, community-based 18-month diet-induced weight loss and exercise intervention in three North Carolina counties with a diverse socioeconomic and socioeconomic makeup significantly reduced knee pain in overweight and obese adults with knee OA relative to an attention control group. Many physicians who treat knee OA have no effective ways to start weight loss and exercise therapies. This report is significant in that it will determine the efficiency of a long-awaited and much needed community-based program that will serve as a blueprint for physicians and public health officials in both urban and rural areas to implement a weight loss and exercise program designed to reduce knee pain and other health problems in overweight and obese people with knee OA that can be sustained long-term and at a reasonable price.

Source link: https://clinicaltrials.gov/ct2/show/NCT02577549


Virtual Reality Meditation for Fatigue in Persons With Rheumatoid Arthritis

"While recent medical advancements have improved diagnosis of the disease, a vast number of outpatients with RA still suffers from exhaustion. " Meditation has been extensively researched and successfully used in RA and other rheumatic diseases, but, to date, no such meditation has been implemented in this population. Adult outpatients with clinically diagnosed rheumatoid arthritis will be enrolled at a local rheumatoid arthritis clinic and use VR in their own homes. Patients will have the opportunity to choose from several virtual outdoor settings, three styles of meditation, and three session lengths when Donning an Oculus Quest VR headset and using two handheld controllers. The results of this feasibility study will include: Acceptability, desire, implementation, integration, expansion, and "limited" efficacy testing of using VR meditation for managing fatigue in outpatients with RA.

Source link: https://clinicaltrials.gov/ct2/show/NCT04804462


Impact of Rheumatoid Arthritis on Body Composition, Bone Marrow Adiposity and Bone Mineral Density: a Case-control Study

"Avoiding lean body mass, bone mass, and an accumulation of fat mass can cause rheumatoid arthritis, body composition is altered during rheumatoid arthritis. " This pilot case-control study will compare body composition, bone marrow adiposity, and bone mineral density in patients with RA versus healthy volunteers.

Source link: https://clinicaltrials.gov/ct2/show/NCT05269069

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions