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Apoptosis - OSTI GOV

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Last Updated: 25 June 2022

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Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis

Receptor-mediated apoptosis is mediated by two routes: one requiring only a cascade of initiator and effector caspase caspases, the other requiring an initiator and effector caspase cascade, and mitochondrial outer membrane permeabilization are required for mitochondrial outer membrane permeabilization. The ratio of XIAP to pro-caspase-3 concentrations, according to the resulting phase diagrams, leads to a significant regulatory role: type I activity predominates when the ratio is low, while type II behavior when the ratio is high. By XIAP, we also extended phase space analysis to mutations impacting caspase-3 ubiquity, increasing the rate of caspase-3 ubiquity by XIAP's rate of caspase-3 ubiquityization, predicting and showing that such mutations abolish all-or-none control over effector caspases.

Source link: https://www.osti.gov/biblio/1623803

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions