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Apert Syndrome - PubAg

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Last Updated: 16 October 2021

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Absceso cerebral por Haemophilus influenzae serotipo e en un paciente pediátrico con síndrome de Apert

We report a case of a brain abscess triggered by Haemophilus flu type e in a 12 year-old patient struggling with Apert syndrome. Apert syndrome is identified by the premature closure of cranial sutures. In 2010 the patient experienced head trauma in the frontal location with cranial fracture and a cerebrospinal fluid fistula. A gram unfavorable coccobacillus was isolated and recognized as Haemophilus influenzae serotype e. Empirical treatment was started with meropenem and vancomycin, which was later switched to ceftriaxone and metronidazole after society results arrived.

Source link: https://pubag.nal.usda.gov/catalog/6978702


Mesodermal expression of Fgfr2S²⁵²ᵂ is necessary and sufficient to induce craniosynostosis in a mouse model of Apert syndrome

Coordinated development of the skull and brain are vital to typical human development. Syndromic craniosynostosis is brought on by a variety of hereditary lesions, many frequently by triggering anomalies of FGFRs 1-- 3, and suspending anomalies of TWIST1. In a mouse version of TWIST1 haploinsufficiency, cell mixing in between the neural crest-derived frontal bone and mesoderm-derived parietal bone comes with coronal suture blend during beginning advancement. Nevertheless, the significance of family tree blending in craniosynostosis generated by triggering FGFR anomalies is unknown. Here, we show an unique mechanism of suture blend in the Apert Fgfr2S ²⁵² ᵂ mouse version. Using Cre/lox recombination we at the same time induce expression of Fgfr2S ²⁵² ᵂ and β-galactosidase in either the neural crest or mesoderm of the skull. We eliminate postulated duties for dura mater or head base changes in craniosynostosis. The practicality of conditionally mutant mice allows post-natal evaluation of various other aspects of Apert syndrome.

Source link: https://pubag.nal.usda.gov/catalog/809929

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions