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Aortic Aneurysm - U.S. Department of Veterans Affairs

Summarized by Plex Scholar
Last Updated: 07 June 2022

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Lipid phosphate phosphatase 3 in smooth muscle cells regulates angiotensin II-induced abdominal aortic aneurysm formation.

"LPP3 is quickly upregulated in the context of vascular inflammation, with particularly prominent expression in smooth muscle cells; however, the effect of LPP3 on vascular pathology is not clear. " We investigated the role of LPP3 and lysophospholipid signaling in a well-defined model of pathologic aortic disease, and observed that Angiotensin II raises expression of PLPP3 in SMCs through nuclear factor kappa B-specific deletion or SMC-specific deletion shields hyperlipidemic mice from AngII-mediated aneurysm formation. The LPP3 gene regulates SMC differentiation state, and lowering LPP3 levels promotes a fibroblast-like appearance, according to LPP3.

Source link: https://doi.org/10.1038/s41598-022-08422-7

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions