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The aorta, the large blood vessel that distributes blood from the heart to the rest of the body, is involved in the thoracic aneurysm and dissection. Other vessels that carry blood from the heart to the remainder of the body may also be affected. Aortic dilatation can also lead to a sudden tearing of the layers in the aorta wall, allowing blood to flow abnormally between the layers. The first sign of familial TAAD to develop is usually dilatation, although dissection in some affected individuals shows no or no aortic dilatation. There are no signs of symptoms in Aortic aneurysms, but they do not appear. Commonly, sudden chest or back pains can arise from the use of acute, sudden chest or back pains, and may lead to unusually pale skin, a very thin pulse, numbness, or tingling in one or two limbs, or paralysis. The traumatic TAAD may not be related to other signs and symptoms. However, some people in impacted families have mild signs of Marfan syndrome or Loeys-Dietz syndrome. Aneurysms in the brain or in the abdomen section of the aorta are common in families with a telia. Heart abnormalities that are present from birth are found in people with familial TAAD. A soft out-pouching in the lower abdomen, an abnormal curvature of the spine, or a purplish skin discoloration caused by abnormalities in the skin's tiny blood vessels may occur.
Loeys-Dietz syndrome is a disorder that affects the connective tissue in several regions of the body. Loeys-Dietz syndrome may be present from childhood to adulthood, and the severity is variable. The enlargement of the aorta, which is the large blood vessel that distributes blood from the heart to the remainder of the body, is characteristic of Loeys-Dietz syndrome. Stretching of the aorta may lead to a sudden tearing of the layers in the aorta wall. People with Loeys-Dietz syndrome may also have aneurysms or dissections in arteries throughout the body, and have arteries with abnormal twists and turns. Dural ectasia typically does not cause health problems in people with Loeys-Dietz syndrome. Loeys-Dietz syndrome is a common symptom of Loeys-Dietz syndrome and can result in spinal cord injury. People with Loeys-Dietz syndrome may bruise quickly and develop abnormal scars after wound healing. Some people with Loeys-Dietz syndrome have an abnormal accumulation of air in the chest cavity that may result in the loss of a lung or a protrusion of organs due to muscle deficits. Individuals with Loeys-Dietz syndrome have a tendency to experience immune system disorders such as food allergies, asthma, or inflammatory diseases such as eczema or inflammatory bowel disease.
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