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Antimicrobial Resistance - Wiley Online Library

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Last Updated: 03 July 2022

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Resistance and tolerance of Mycobacterium tuberculosis to antimicrobial agents—How M. tuberculosis can escape antibiotics

The treatment of acute TB patients largely depends on several anti-tuberculosis drugs. Mtb's drug action and drug resistance study, as well as drug prevention, provide a new tool for clinical care of TB patients and prevention of drug resistance. In this report, we summarized the molecular mechanisms of drug resistance of current anti-u2010TB drugs in order to better understand the evolution of drug resistance of Mtb, which will provide more effective measures against drug-resistant TB and accelerate the completion of the EndTB Initiative by 2035.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/wsbm.1573


Pathogenicity potential of antimicrobial‐resistant Photobacterium damselae subsp. damselae isolated from maricultured and wild‐caught fish of the southeast coast of India

Two of the latest mariculture issues are antimicrobial resistance and zoonotic pathogen transfer from wild fish to high-u2010density cages and u2010cultured fish. P. damselae subpoena subsp. Out of 280 isolates, 61 isolates were reported as P. damselae subsp. P. damselae subsp. 'sp. at the overall incidence of P. damselae subsp. In wild fish, the damselae in wild fish was significantly higher than cage-u2010cultured fish. Parrot fish were more prevalent among the wild fish than other fish. A challenging research was conducted to find the virulence of P. damselae bacteria isolated from wild fish to commercially important cage u2010cultured fish experimentally. According to the study, cobia and silver pompano displayed 100% and 85 percent mortality at a bacterial concentration of 3. 5 % Fishu22121, respectively. In conclusion, the current report revealed a high prevalence of AMR in P. damselae subsp.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/are.15948


Investigation of the effects of antimicrobial and anti‐biofilm peptide IDR1018 and chitosan nanoparticles on ciprofloxacin‐resistant Escherichia coli

Peptide IDR1018 and chitosan nanoparticles had antimicrobial and anti-u2010biofilm activity against bacteria, according to bacteria. On 50 clinical isolates of uropathogenic Escherichia coli resistant to ciprofloxacin were tested in this study. Antimicrobial and synergistic activity of peptide IDR1018 and CNs with ciprofloxacin was determined by a microtiter broth dilution process. In combination with ciprofloxacin, the checkerboard test was used to determine the antimicrobial effects of IDR1018 and CNS. The effect of ciprofloxacin, peptide IDR1018, and CNs was measured using the crystal violet method. A synergistic effect of ciprofloxacin in combination with peptide IDR1018 was found in combination with peptide IDR1018, but in combination with CNs, this antibiotic had an additive effect. Our findings revealed that the peptide IDR1018 and CNs had antimicrobial activity on UPEC isolates. By peptide IDR1018 and CNs in a concentration-u2010dependent manner, biofilm inhibition and biofilm eradication of clinical isolate was shown.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jobm.202200156


Parents’ awareness of antimicrobial resistance: a qualitative study utilising the Health Belief Model in Perth, Western Australia

In Perth, Western Australia, this report sought to identify local factors that promote or prevent parents from using antibiotics for their children. Participants agreed that antimicrobial resistance is a significant health issue. However, participants admitted that they were unaware of AMR, limiting their ability to determine the risks of finding AMR infections among their children. Participants understood the dangers and dangers of antibiotic use, but they also considered antibiotics as a time-saving measure that minimized disruption to their daily lives. Participants' experiences with their children's illness raised their optimism and connected their positive and negative experiences with their general practitioners in their judicious use of antibiotics. Implications for public health: The results show that including parental involvement and involvement in decision-u2010making regarding antibiotic use, as well as establishing a positive relationship with healthcare providers were two key steps to encourage the appropriate use of antibiotics.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/1753-6405.13265


Distribution of Vibrionaceae in farmed Asian sea bass, Lates calcarifer in Thailand and their high prevalence of antimicrobial resistance

This report describes Vibriosis' etiological agent, as well as its distribution and antimicrobial resistance profiles among farmed Asian sea bass in Thailand. The study found 283 Vibrionaceae from 15 Asian sea bass farms located around the provinces of the Andaman Sea and Gulf of Thailand coasts to determine the distribution and antimicrobial resistance profiles. Only V. harveyi was found to cause clinical signs of muscle necrosis and scale loss in Asian sea bass, according to a laboratory challenge experiment. The results of an antibiotic resistance test showed a strong resistance to antibiotics including metronidazole, streptomycin, clindamycin, colistin sulphate, and amoxicillin. 100% of Vibrionaceae isolates are vulnerable to florfenicol, according to Remarkably. The 28 of 29 resistance profiles were multidrug resistants, with V. vulnificus having the highest MAR value.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/jfd.13667


Prevalence of antibiotic resistance genes in the oral cavity and mobile genetic elements that disseminate antimicrobial resistance: A systematic review

The aim of this study was to determine the prevalence of antibiotic resistance genes in the oral cavity and identify mobile genetic elements that may be helpful in disseminating them. The following English language studies from January 2000 to November 2020 were gathered. Overall, tet was the most common gene, while conjugative transposon Tn916 was the most common MGE associated with antibiotic resistance genes in the oral cavity, with antibiotic resistance genes present in the oral cavity. Tet was more prevalent in babies delivered by vaping, although tet was more widespread in those delivered by Cu2010section. Generally speaking, countries with higher consumption of antibiotics had higher numbers of antibiotic resistance genes. Agricultural as well as medical use of antibiotics in a region should always be considered. There was no difference in the prevalence of tet among healthy, periodontitis, and post-u2019implantitis studies; however, erm, tet, and tet were higher in healthy young children than the non-u2010carious group. Compared to those with clean oral hygiene, subjects with bad oral hygiene have more pathogenic bacteria that carry resistance genes than those with good oral hygiene. With a high degree of erythromycin resistance in 65% of Streptococcus salivarius isolates, tetracycline resistance and erythromycin resistance, periodontal pathogens demonstrated significant beta-u2013lactam resistance in up to 90% of samples and the normal oral flora. In 100% of whole saliva samples, the most common resistance gene was tet in root canals, cfxA in subpoena plaque, erm in supracorporeal plaque, and tet in tet in whole saliva samples.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/omi.12375


Antimicrobial use and resistance in food‐producing animals—How can we protect the efficacy of antibiotics for reproductive diseases?

This report includes an overview of antimicrobial use in food-producing animals, a discussion of how antimicrobial use in cattle, the horse, and pig in Europe, where there are differences in treatment methods including options to refine antibiotic use, as well as a summary of antibiotic resistance for some bacteria isolated from the reproductive system. This may necessitate a re-thinking among the animal health campaigners regarding the use of antibiotics, as well as the need for new skill sets in the animal health sector.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/rda.14170

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions