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Prevention of Shiga toxin-producing Escherichia coli foodborne outbreaks has been hampered by its complicated epidemiology. In a series of STEC isolates obtained from cattle hide and faecal samples collected during a national survey carried out in Spain in 2011, and 2013, we investigated the distribution of virulence genes, key serotypes for public health [haemolytic uraemic syndrome -related], antimicrobial resistance profiles, and pulsed-field gel electrophoresis patterns. STEC prevalence in hides was higher than in faeces and O157:H7 was more prevalent in the former. Both STEC and enterotoxigenic pathotypes were more heterogeneous than O157:H7 in their VG profiles, with 25/64 presenting VGs from both STEC and enterotoxigenic pathotypes. At least one antimicrobial was resistant in both cases, but there were no differences in AMR between O157:H7 and non-O157 isolates.
Source link: https://doi.org/10.1017/s0950268816001370
Abstract Long-distance Waiting times have hampered international attempts to combat antibiotic resistance in M. tuberculosis, which is a common disease. Here, we present two deep convolutional neural networks that predict antibiotic resistance in M. tuberculosis isolates based on 18 genomic loci, with AUCs 82. 6-99. 5% and greater sensitivity than state-of-the-art methods; and a set of 13 single-drug CNNs with AUCs 80. 1-97. 1% and higher sensitivity than previous state-of-the-art methods.
Source link: https://doi.org/10.1038/s41467-022-31236-0
SUMMARY Poultry are potential sources of non-typhoidal Salmonella serovars, which can cause foodborne human disease. We conducted a cross-sectional survey to determine the prevalence of Salmonella serovars in egg-laying hens and broilers on the farm level, as well as their susceptibility to antimicrobials commonly used in the poultry industry in Ghana. Salmonella was present in 94/200 samples with an overall flock prevalence of 44 percent at 56%. More than two antimicrobials and shared common resistance to nalidixic acid, ciprofloxacin, and tetracycline were present in all S. Kentucky strains, often in combination with other antimicrobials. In conclusion, poultry raised in Ghana has a high incidence of multi-resistant Salmonella, and the common finding of clonal S. Kentucky in the Kumasi area prompted further investigations into the epidemiology of this serovar.
Source link: https://doi.org/10.1017/s0950268816001126
Abstract The rising prevalence of antimicrobial-resistant bacterial infections has resulted in a significant global public health crisis. However, in the foreseeable future, human healthcare and agriculture will continue to heavily rely on antimicrobials to make acceptable progress in reducing antimicrobial resistance, due to other common environmental conditions preserving antimicrobial resistance and limited executionary potential. To reduce antimicrobial resistance, we anticipate that antimicrobial resistance mitigation techniques for animal agriculture involving many tools would be highly effective ecosystem-level interventions.
Source link: https://doi.org/10.1093/femsec/fiac060
If no action is taken, antimicrobial resistance could result in ten million deaths per year by 2050. This article by The Behavioural Insights Team explores some of the areas where behavioral changes can be used to reduce antimicrobial resistance formation.
Source link: https://doi.org/10.1093/jac/dkac087
Risk equivalence between countries with differing AMU programs must be established using scientifically based risk assessments. The AMR Codex guidelines are therefore preliminary and not a dependable way to determine the effects of livestock AMU reductions on the human health risk of AMR Salmonellosis from beef, but they are also designed to identify regionally comparable risks. More flexible risk assessment guidelines that more specifically link livestock AMU to human health risk are required, as well as more openly link livestock AMU to human health risk, are required to account for country variances and the estimation of comparable regional risk estimates, which can be used to influence international trade policy.
Source link: https://doi.org/10.4315/jfp-22-038
Abstract based on a page from the National Action Plan outlines antimicrobial resistance in China's backdrop of universal healthcare coverage and pre-existing regulations on antimicrobial use. This report aims to explore how Guangdong, a province, implements national AMR policies in a tightly controlled public policy framework and an economy plagued by high inequalities. We also identify pre-existing medical and public policies that connect with antimicrobial resistance policies. Our findings point to the need for AMR in China, highlighting the importance and policies around antimicrobial use control.
Source link: https://doi.org/10.1093/heapol/czac052
Antimicrobial resistance has risen to become a global public health concern, and antibiotic agents have lagged behind the increase in bacterial resistance. In addition, the benefits and drawbacks of phage therapy as an antibiotic alternative to AMR are also addressed in this study.
Source link: https://doi.org/10.3390/microorganisms10071324
As a result, antibiotics no longer function and bacteria continue to grow. The pandemic of COVID-19 and Antimicrobial drug resistance are closely linked and interrelated medical problems, despite there being a causal link between the human race and high mortality. In this fast-growing research field, this paper explores the relationship between rise rates of antimicrobial resistance and Covid-19 pandemic conditions in Bulgaria and Europe.
Source link: https://doi.org/10.2478/asn-2022-0005
We wanted to establish Salmonella contamination during cattle slaughter in South African rural abattoirs and environmental samples. In total, 92 Salmonella species isolates were found. Other external factors also play a significant role in carcass contamination, according to the inconsistent occurrence of the diverse Salmonella serovars on hides, carcasses, and intestinal contents. Despite being extremely difficult to at least one antimicrobial strain during animal production, most Salmonella isolates were resistant to at least one antimicrobial, with the most notable resistance seen toward oxytetracycline. In conclusion, cattle raised in South African rural abattoirs contain a variety of Salmonella serovars that are immune to antimicrobials, posing a public health threat.
Source link: https://doi.org/10.4102/ojvr.v83i1.1109
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