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Anorexia Nervosa - Springer Nature

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Last Updated: 07 June 2022

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In silico identification of the rare-coding pathogenic mutations and structural modeling of human NNAT gene associated with anorexia nervosa

"Purpose" was given a raised susceptibility to anorexia nervosa in the case of decreased quantities of neuronatin gene. We wanted to investigate the most pathogenic rare-coding mutations, non-synonymous single-nucleotide polymorphisms of NNAT, and their potential detrimental effects on protein function through transcript level sequence and structure based in silico approaches. SNPs were trained for transcript level SNPs analyses and to identify high-risk rare-coding nsSNPs, as well as their effect on protein stability function. Following the discovery of binding free energies, AN 3D therapeutic compounds that followed the establishment of drug-likeness were docked with the most pathogenic variant of NNAT. The 3D-modeling analysis of AN drugs revealed the lowest bond free energy and significant inhibition constant with mutant models C30Y and C30Y, respectively. Conclusions The acetylation site K59 found that a mutant model with high drug binding affinity and the most common interaction was observed. Evidence No evidence The evidence amount is not clear; open access bioinformatics research is based on research. No amount of evidence exists at this moment.

Source link: https://doi.org/10.1007/s40519-022-01422-6


Not just an upset stomach: gastric perforation in a patient with anorexia nervosa

"Gastric perforation in patients with anorexia nervosa is a rare entity associated with elevated morbidity and mortality," Norris in Int J Eat Disord 49:216, 2016]. We discuss a case of gastric perforation with restrictive anorexia nervosa, as well as delayed medical signs of medical anxiety, contributing to abdominal compartment syndrome. ".

Source link: https://doi.org/10.1007/s40519-021-01312-3


When anorexia nervosa symptoms mask Kallmann syndrome

"Background" Although anorexia nervosa can delay puberty, a well-designed assessment at its onset is still crucial in excluding congenital delayed puberty disorders. During a follow-up to a 15-year-old girl suffering from anorexia nervosa, a change in treatment has resulted in a long medical history that has confirmed the absence of the olfactory bulb. On a blood test, a blood test was determined, and the patient was treated with a multidisciplinary approach. Without considering medical history, a delayed puberty is attributed to anorexia nervosa itself.

Source link: https://doi.org/10.1007/s40519-021-01332-z


Structural brain abnormalities in adolescent patients with anorexia nervosa at both the acute and weight-recovered phase

"Previous cross-sectional studies have revealed that adolescent patients with anorexia nervosa showed global gray matter volume decreases at the acute phase, which were revived at the weight-recovered stage, relative to healthy controls. " In 31 adolescent patients with AN in the acute phase and 16 patients with AN in the follow-up weight-recovered phase, over an approximately 1-year follow-up period, as well as cortical thickness measurements for GM and WM were carried out, as well as cortical thickness measurements for GM and WM. Patients in complex brain regions showed significant reductions of GMVs and cortical thickness in the acute phase relative to HC. Compared to the HC, the AN patients' weight-recovered phase showed significant GMV reduction in the left hippocampus and a WMV decrease in the pons. The volume reductions found in the hippocampus and pons in the weight-recovered phase may have delayed neurogenesis or starvation in the AN patients.

Source link: https://doi.org/10.1007/s11682-021-00622-5


Validating the Danish version of the Eating Disorder Quality of Life Scale (EDQLS) in anorexia nervosa

"Purpose" is the product of this study's aim was to investigate the factor structure of the Danish translation of the eating disorder quality of life questionnaire, as well as assess the internal validity and convergent validity of the scale in a Danish cohort of women with AN. Methods The total sample consisted of 211 patients diagnosed with anorexia nervosa age 13:2013-40 years. The eating disorder quality-of-life scale total score was found to have high internal consistency. Conclusion This research supports the use of the complete score of the eating disorder quality of life scale in assessing quality of life in patients with anorexia nervosa. ".

Source link: https://doi.org/10.1007/s40519-021-01310-5


Adolescents with anorexia nervosa with or without non-suicidal self-injury: clinical and psychopathological features

"Purpose Anorexia nervosa and non-suicidal self-injury were both typical in childhood development, with greater incidence in females and similar risk factors. " However, psychological indicators of eating disorders in this population are also underfunded, particularly due to psychological disorders. Methods The present study aims to evaluate clinical and behavioural characteristics of 253 female adolescents with or without NSSI, as well as potential clinical and psychological predictors of NSSI presence. Results AN + NSSI group showed a higher prevalence of binging (U2013purging-type AN), as well as a higher age and Body Mass Index in comparison to AN without NSSI group. Conclusions: The results of the study show that adolescents with AN and NSSI have unusual clinical features, with increased incidence of binging-type AN and more severe psychopathological characteristics than adolescents with NSSI-unsupervised.

Source link: https://doi.org/10.1007/s40519-021-01311-4


Everyday flexibility and functional milestones in anorexia nervosa: survey results from a mixed community sample

"Purpose This report investigated the correlation between self-reported cognitive-behavioral stability scores on the Eating Disorder Flexibility Index and objective social and occupational milestones in participants with a lifetime diagnosis of anorexia nervosa. Methods 114 female adult participants with a current or past partial AN syndrome diagnosis completed an online poll that included functional milestone questions, the EDFLIX, WSAS, EDE-Q, and DASS-21. Results Everyday flexibility scores were highly correlated with WSAS rankings, but not functional milestones for the same area. Lower flexibility was attributed to increased WSAS work exhaustion, but it was not associated with poor occupational outcomes. Lower elasticity was due to increased WSAS social inactivity, but was not related to less frequent social interactions with friends. The subjective WSAS function test and the more concrete operational milestones were not consistent. "The evidence is at an end. Numerical case" is a case study done in the United States, with the determination of evidence Level III of the Case III. u2013control analytic analysis.

Source link: https://doi.org/10.1007/s40519-021-01300-7


A next generation sequencing gene panel for use in the diagnosis of anorexia nervosa

"The motivation behind this study is that we first investigate the genes underlying syndromic forms of AN, then genes that were found to have rare variants in AN patients that had undergone segregation analysis, and then candidate genes that have been identified in the same molecular pathways or mouse models that have been identified by GWAS or in mouse models. " PT,2 and SGPP2 are among the 12 genes involved in syndromic anorexia and predicted deleterious variants in two genes associated with syndromic forms of anorexia and predicted deleterious variants in the following 12 genes in our review: CD36, CACNA1C, DRD4, EPHX2, EPHX2A, GRIN3A, LRP2, NPY4R, PTGS2, PTPN2A Physiographic PTPN2 PTPP2 Physio2 Physiologic Physio2A GP2A physiomic versions of anorexia GG2A do physiomic anorexia and predicted deleterious anorexia, EPHX2A, ESR1, EGRIN1C, DRD4A, EPHX2A, EPF2A, ESR1, ETR1, ESR1, m2A, EGRIN2A, EHR1, EPHX2, et, CGIA, CARN1, EX2, a, The main finding of our research is the discovery of the NNAT gene in AN's pathogenesis; furthermore, this report shows that NGS-based testing can play a significant role in the diagnostic evaluation of AN, excluding syndromic forms and increasing knowledge of the genetic etiology of AN.

Source link: https://doi.org/10.1007/s40519-021-01331-0


State or trait: the neurobiology of anorexia nervosa — contributions of a functional magnetic resonance imaging study

"Background" is a newspaper that publishes news about the epidemiology of anorexia nervosa with a focus on state-versus trait-related abnormalities is limited. With clinical remission, there are signs of the restoration of structural brain alterations. Methods We compared women with AN, well-recovered female participants, and non-patients cross-sectionally. To compare neural responses to food versus non-food images, functional magnetic resonance imaging was used. Functional responses and affective ratings did not differ between REC and NP, even when using lenient thresholds for the comparison of neural responses. During the acute phase of anorexia nervosa, there is a slew of evidence of structural and functional brain changes, however the effect on brain regions is variable, depending on various research methods. Participants who were exposed to food photography were investigated on a scientific basis. The REC differed from the NP group neither in terms of function nor emotional experience of food stimuli.

Source link: https://doi.org/10.1186/s40337-022-00598-7


Estimation of meal portions in bulimia nervosa compared to anorexia nervosa and healthy controls

"Purpose Bulimia nervosa and anorexia nervosa are both potentially life-threatening eating disorders that mostly affect young people, predominantly women. " People with AN tend to overestimate food portion sizes compared to healthy controls, according to a previous research, but no research has investigated this behavior in BN, which was the subject of this study. Methods Women with BN, AN, and HC were asked to determine different meal portion sizes in two situations, whether they were supposed to eat them or not general. Conclusion When estimating food portion sizes, people with BN appear to fall intermediately between HC and AN. The most prominent with higher proportion estimates were ED symptoms in BN. Evidence obtained from well-planned controlled trials with no randomization. ".

Source link: https://doi.org/10.1007/s40519-022-01410-w

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions