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Anorexia Nervosa - Europe PMC

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Last Updated: 07 June 2022

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Encountering patients with anorexia nervosa - An emotional roller coaster. nurses' lived experiences of encounters in psychiatric inpatient care.

"Purpose": The aim of this study was to clarify nurses' lived experiences of encounters with adult patients with anorexia nervosa in psychiatric inpatient care. With 11 nurses who had knowledge of dealing patients with anorexia nervosa in psychiatric inpatient care, personal interviews with a narrative approach were conducted using a narrative approach. In all nurse-patient encounters, being able to strike the balance between one's corporate function, seeing the person behind the patient, and the illness is vital.

Source link: https://europepmc.org/article/MED/35481811


Multiomic prioritisation of risk genes for anorexia nervosa

"Anorexia nervosa is the most common cause of death among psychiatric disorders worldwide. " After multiple-testing results, we discovered 134 genes for which genetically predicted mRNA expression was linked to anorexia nervosa, as well as four proteins and 16 alternatively spliced transcripts. Conditional investigation of these highly related genes on other proximal association genes resulted in 97 genes that are not associated with anorexia nervosa. Pathway's analysis of genes revealed by finemapping identified the pathway of immune system function as statistically overrepresented. In summary, we used multiomic databases to genetically prioritize novel risk genes for anorexia nervosa that warrant further investigation. ".

Source link: https://europepmc.org/article/PPR/PPR502585


In silico identification of the rare-coding pathogenic mutations and structural modeling of human NNAT gene associated with anorexia nervosa.

"Purpose Increased susceptibility toward anorexia nervosa was found with decreased amounts of neuronatin gene. " We wanted to investigate the most pathogenic rare-coding mutations, non-synonymous single-nucleotide polymorphisms of NNAT, and their potential deleterious effects on protein function by transcript level sequence and structure based on silico approaches. SNPs were obtained for transcript level SNPs analyses and to identify high-risk rare-coding nsSNPs, as well as their impact on protein stability function, according to Distinctive in silico algorithms. Following the application of drug-likeness, three AN 3D therapeutic compounds were docked with the most pathogenic variant of NNAT to determine the medications' binding free energies. For mutant models C30Y, the 3D-modeling study of AN drugs' binding energies indicated the lowest binding free energy and significant inhibition constant. Conclusions The acetylation site K59" has a mutant model with a significant drug binding affinity and the commonest interaction observed.

Source link: https://europepmc.org/article/MED/35655118


Young women who develop anorexia nervosa exhibit a persistently low premorbid body weight on average: A longitudinal investigation of an important etiologic clue.

"Objective assessment whether young women who have subsequently demonstrate anorexia nervosa develop persistently low average premorbid BMI; a proximal increase in other risk factors distinguish youth who have persistently low BMI from those who do not. " Youth with persistently low BMI reported lower pressure for thinness, body dissatisfaction, and death at baseline, showing that these factors did not cause the low BMI. BMI on average among young women who experience AN onset of an onset is low, and it suggests that etiologic programs should reflect this finding and recommend appropriate prevention services for low-BMI adolescent girls. ".

Source link: https://europepmc.org/article/MED/35653756


Indicated Web-Based Prevention for Women With Anorexia Nervosa Symptoms: Randomized Controlled Efficacy Trial.

"Background While preventive interventions for eating disorders in general have demonstrated promise, studies aimed at people at risk of anorexia nervosa are lacking. From 3 German universities, as well as on the web and randomized to Student Bodies-AN or a wait-list control group, a total of 168 women with low body mass and high weight issues, high body mass, and heavy restricted eating were recruited, as well as a high body mass and obesity problems, elevated body fat, high weight worries, and heavy hungry eating. In the group of participants who were underweight, the key findings were scientifically significant shifts in disordered eating habits and habits, as well as change in BMI at 12-month FU. After the intervention, 81. 5% of the women recovered, and 59 percent of the women at 12-month FU were pregnant. The IG participants' Eating Disorder Examination total scores dropped at 12-months overall, while the CG participants and the IG participants who were underweight had larger clinically significant increases in BMI than the CG participants, but these differences were not significant. In the IG, the prevalence of new-onset eating disorder disorders in the IG was lower than in the CG, and the reductions in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition-based eating disorder syndromes were greater in the IG than in the CG, at both time points. Conclusions SB-AN is the first preventive measure shown to dramatically reduce identifying risk factors for, and symptoms of, AN, and it shows promise for reducing full-syndrome AN onset.

Source link: https://europepmc.org/article/MED/35653174


Promising effect of multi-family therapy on BMI, eating disorders and perceived family functioning in adolescent anorexia nervosa: an uncontrolled longitudinal study.

"This contribution examines the results of uncontrolled longitudinal study examining the results of a Multi-Family Therapy as an anti-adolescent Anorexia Nervosa treatment as well as the role of perceived family participation in these outcomes. " These findings add to MFT's growing success in mental stability, weight loss, and reported family functioning among adolescents with AN. ".

Source link: https://europepmc.org/article/MED/35649125


State or trait: the neurobiology of anorexia nervosa - contributions of a functional magnetic resonance imaging study.

"Background" is limited in terms of anorexia nervosa's cerebral neurobiology with respect to state-versus trait-related abnormalities. With clinical remission, there is evidence of the restoration of structural brain changes. Functional magnetic resonance imaging was used to determine neural responses to food and non-food images. Functional responses and affective ratings did not differ between REC and NP, even when using lenient thresholds for the comparison of neural responses. Comparing REC and AN, the former displayed lower valence and higher arousal ratings for food stimuli, as well as neural responses in an occipital zone. ".

Source link: https://europepmc.org/article/MED/35641995


Modified metacognitive therapy for anorexia nervosa: An open trial in an outpatient setting.

"Objective": According to the latest study, treatment for adults with anorexia nervosa needs to be improved, since recovery rates are poor to moderate, and relapse rates are high. Metacognitive therapy is a safe and effective treatment for anxiety and depression. Method Twenty-four patients with AN were involved in an open trial of modified metacognitive therapy. Results And Conclusions As well as statistically significant shifts from pre- to post-treatment in the group's studies, there were also clinically significant changes in individual patient levels for eating disorder and depressive disorders, as well as weight management. Attention to adults with anorexia nervosa requires improvement. According to research, Metacognitive therapy is a safe way to treat anxiety and depression, and it can be applicable to the eating disorders. This small open trial shows that MCT can be modified to treat patients with anorexia nervosa. '.

Source link: https://europepmc.org/article/MED/35635052


Low-Dose Olanzapine in the Treatment of Adolescents with Anorexia Nervosa: An Observational Naturalistic Case-Control Study.

"Background: Although recent studies have investigated the use of low-dose olanzapine in various psychiatric disorders, only one review has evaluated the therapy in 13 girls with anorexia nervosa. " Methods: Objectives: The aim of this observational naturalistic case-control study was aimed at determining the use and tolerability of low-dose olanzapine in the context of a multidisciplinary hospital intervention for adolescents with AN. Comparison of three groups with AN Antenna versus the others: group 1 was treated with low-dose olanzapine, group 2 had full-dose olanzapine, and group 3 was treated without antipsychotics. Individuals treated with full-dose olanzapine saw a significant decline in depressive measures, including BDII and SAFA-D, relative to the other groups. This naturalistic controlled research extends the existing data on the use and tolerability of low-dose olanzapine in adolescents with AN. ".

Source link: https://europepmc.org/article/MED/35612433


Cognitive flexibility and the risk of anorexia nervosa: An investigation using self-report and neurocognitive assessments.

"The current research aims to 1 investigate cognitive flexibility in people at different levels of risk of AN; and 2 compare people with a history of AN to people at various risk of cognitive flexibility. " Participants completed the Depression Anxiety Stress Scale short-form version, the Eating Disorders Examination-Questionnaire, the Neuroticism Scale, and the Cognitive Flexibility Inventory and neurocognitive the Trail Making Test and the Wisconsin Card Sorting Test online to measure eating disorder symptoms, anxiety, mistrust, and cognitive flexibility. Although high-risk participants reported significantly less cognitive flexibility among the other risk groups, their neurocognitive abilities remained stable across organizations. Participants with lifetime AN also reported significantly less cognitive flexibility than the low-risk group. People with a high risk of AN may have less cognitive flexibility than those with a lower risk of AN.

Source link: https://europepmc.org/article/MED/35636028

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions