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"The increasing concern about the role of metabolic sensors in various eating disorders has led to the introduction of a strict protocol to collect, store, and process blood samples in clinical studies. " Indeed, blood esterases are rapidly degrading the acyl ghrelin isoform, degrading it into desacyl ghrelin, converting it into desacyl ghrelin, a very common occurrence, so optimal conditions for AG storage and accurate determination of AG/DAG ratios should be used. Patients with restrictive-type anorexia nervosa before and after nutritional recovery were characterized under such circumstances. We illustrate the pulsatile variations of ghrelin isoforms in three patients with AN-R who are hungry and hungry. These assay conditions could therefore be used to clarify specifically the role of ghrelin isoforms on eating behavior in physiological and pathological conditions.
Source link: https://doi.org/10.1016/j.cpnec.2022.100140
"BackgroundAnorexia Nervosa occurs normally during early childhood, a key period of personality growth. " A substantial number of adolescent AN patients have impaired mental stability, which may be a pertinent but understudied condition of illness severity. paraphrasedoutput:MethodsThis study looked at existing studies of N = 60 adolescents with AN. The social status of identity as a key component of personality has been shown to influence inpatient treatment results in adolescents with AN. During ten weeks of inpatient therapy, three different models explored the effects of identity functioning, as determined by the Assessment of Identity Development in Adolescence at admission, on weight gain [BMI-SDS ]. Higher weight gain during inpatient therapy was also predicted by other psychopathology tests, but not AIDA scores. Conclusion: "In adolescent AN patients who have difficulty creating a stable identity," adolescent AN patients who have trouble creating a stable identity were both delayed in maintaining a stable identity. ".
Source link: https://doi.org/10.3389/fpsyt.2022.887588
"Background: Anorexia nervosa has a high incidence of persistent disease and mortality. " For the time being, there are insufficient studies into the predictors of relapse after weight normalization, which is why a systematic literature review was carried out. If they concentrated on predictors of relapse after weight normalization in AN, all research designs were eligible for inclusion. The majority used a prospective observational research methodology, a few used a retrospective observational approach, and just one was a non-randomized control trial. The top predictors of relapse were estimated relapse rates of 50% at 12 months, with estimates of body fat and leptin levels at discharge. BMI at the end of treatment is a predictor of relapse in AN, which is why treatment should focus on a BMI well above 20. ".
Source link: https://doi.org/10.3390/jpm12050836
"We investigated the short-term effects of inpatient therapy on depressiveness and eating disorder psychopathology using the self-rating Major Depression Inventory and Eating Disorder Examination for patients with AN. " Material: Forty-nine patients with AN were observed over eight weeks with baseline psychometric data, EDE-q at baseline and endpoint, and weekly MDI self-scoring. Inpatient therapy lowered MDI consistently over 8 weeks, and this decrease in MDI was positively related to a decrease in EDEq during inpatient therapy. ".
Source link: https://doi.org/10.3390/jpm12050682
Patients and their families' families "Anorexia nervosa patients and their relatives all share alexithymia, anxiety, depression, and other emotional signs in the context of altered attachment. " We sought to describe a sample of Italian families affected by AN, notably including siblings; investigate patient-patient relationships; and assess intergenerational consequences. In most participants, parental bonding was found to be suboptimal, but no obvious connection was established between specific parenting styles and other measurable characteristics, nor did we find any other relevant intergenerational correlation. Anorexia nervosa "implicites psychological difficulties for all family members. ".
Source link: https://doi.org/10.3390/bs12050123
"Axidative stress refers to a lack of reactive oxygen species and antioxidative defense mechanisms. " The genesis of multiple psychiatric disorders has made oxidative stress a central area of study and has been traced to multiple psychiatric disorders. Some oxidative stress parameters in anorexia nervosa patients, including the gut microbiota-derived metabolite trimethylamine N-oxide and polyphenols, have not been investigated before. TAC in AN patients correlated with EPA r sp = 0. 009, t = 0. 019. ".
Source link: https://doi.org/10.3390/antiox11050842
In both mental health disorders, executive functioning problems have been implicated. " However, there are few studies that specifically comparing these functions in AN and OCD, respectively. This report provides a synthesis of behavioral and neuroimaging research into executive functioning in AN and OCD to address this knowledge gap. We present a summary of the similarities and differences in psychological and neuroimaging results between AN and OCD, focusing on set shifting, working memory, response inhibition, and response monitoring.
Source link: https://doi.org/10.3389/fnhum.2022.841633
"When completing a disorder-specific food craving task, a magnetoencephalogram was used to record the neuronal response in seven patients with treatment-resistant ANs. The patients underwent a 15-month course, where MEG scans were performed pre-operatively, post-operatively, and post-operatively before the deep brain stimulation switch was switched on, twice during a blind on/off month and at protocol end. At 12 months of stimulation, three patients met the requirements as responders, resulting in fewer eating disorder psychopathology reductions of over 35%. In ON versus to OFF sessions for all seven patients, an increase in alpha power, as well as invoked power at latencies traditionally associated with visual processing, working memory, and contextual integration was observed. These results show that DBS modulates neuronal function in areas far outside the stimulation target site and latencies, possibly reflecting task specific processing, thus giving further evidence that deep brain stimulation can play a role in the treatment of otherwise intractable psychiatric disorders. ".
Source link: https://doi.org/10.3389/fnbeh.2022.841843
"Objective" study indicates that patients with anorexia nervosa have an impaired ability to mentalize. paraphrasedoutput:Methods is a member of the Royal Institute of Biological Studies The aim of the research was to investigate RF in sessions of patients with AN and its relationship with outcome and type of therapy. Transcripts from 84 sessions of 28 patients were evaluated using the In-Session-Reflective-Functional-Scale [14 cognitive-behavior therapy, enhanced; 14 patients were in need of medication, 14 with good, 12 with poor results after 1 year]. The results point to a correlation between RF rise and a positive result. No association was found between RF and depressive signs or the therapeutic alliance, nor was there one. DiscussionThe following is a discussion that appeared to have a poor ability to mentalize in sessions, which may be at least partially dependent on the degree of starvation. ".
Source link: https://doi.org/10.3389/fpsyt.2022.814441
"Methods is a child with the gene or juvenilehood of appetitive learning in adolescents and young adults with AN. This multi-modal research will use a Pavlovian appetitive conditioning framework to investigate the origins, disappearance, spontaneous recovery, and reinstatement of appetitive conditioning in adolescents and young adults with AN. Discussion This research will be the first to investigate appetitive conditioning in AN u2014, a disorder characterized by increased hedonic response to food. The findings will help establish objective biomarkers of appetitive conditioning in AN and lay the groundwork for the development of novel approaches of therapy for AN and other psychiatric disorders involving decreased ability to enjoy pleasure and reward. ".
Source link: https://doi.org/10.1186/s40337-022-00546-5
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