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"OBJECTIVE: "There is good evidence that family-based therapy is safe in cases of adolescent anorexia nervosa. " Although family-based therapy has been researched in English-speaking countries, it is also necessary to investigate the generalizability of this approach to non-English speaking cultures. METHOD: METHOD's longitudinal study of adolescents with anorexia nervosa identified with the Diagnostic and Well-Being Assessment referred to hospitalization in Su00e3o Paulo, Brazil. The following data were obtained at baseline, at the time of diagnosis, and six months afterward: weight; height; body mass index; menstrual status; Eating Disorder Examination Questionnaire score; and Children's Global Assessment of Functioning Scale score. At the time, the Wilcoxon signed rank test showed statistically significant improvement in body and body mass index at the time of treatment, as well as six months of follow-up, in which none of the patients met the diagnostic criteria for any eating disorder. ".
Source link: https://doi.org/10.1590/s1516-44462010005000001
"Anorexia nervosa is the most common cause of death among psychiatric disorders worldwide. " We discovered 134 genes for which genetically predicted mRNA expression was linked to anorexia nervosa after multiple-testing confirmation, as well as four proteins and 16 alternately spliced transcripts. Conditional testing of these closely related genes on other proximal association genes resulted in the discovery of 97 genes associated with anorexia nervosa. Pathway's analysis of genes revealed by finemapping identified control of immune system function as "overrepresented" "pathway is the only overrepresented. ".
Source link: https://doi.org/10.1101/2022.06.04.22275898
"We investigated diurnal secretion characteristics of leptin, insulin, and cortisol in a research group of anorectic patients prior to refeeding, a second study group of anorectic patients after the establishment of refeeding and research groups of healthy underweight and normal-weight controls. Hyperstarvation in the non-refed patients was correlated with dangerously low plasma leptin levels, a qualitative shift in the circadian rhythm of leptin and cortisol levels, and an increase in the temporal coupling between cortisol and leptin. In comparison, leptin levels in patients who had gained weight were higher; in addition, the diurnal pattern of leptin and cortisol were similar to controls; in the patients who had gained weight, leptin levels were higher; in addition, the temporal relationship of leptin and cortisol were similar to controls. Although cortisol levels in controls and refed patients increased 4 h before leptin, in non-refed patients, they were higher than leptin. ".
Source link: https://doi.org/10.1159/000023274
"BACKGROUND Although preventive interventions for eating disorders in general have shown promise, interventions aimed at individuals at risk of anorexia nervosa are lacking. " A total of 168 women with low body mass and high weight issues, high blood pressure, and heavy restrained eating were recruited from 3 German universities, as well as on the web and randomized to Student Bodies-AN or a wait-list control group. In the group of participants who were underweight, the key findings were clinically significant shifts in disordered eating habits and habits, as well as change in BMI at 12-month FU. RESULTS Data were available for 88. 5 percent of the women after the intervention, and 69% of the women at 12-month FU. The IG participants had larger decreases in Eating Disorder Examination total scores at 12-months after the CG participants and the IG participants who were underweight had smaller clinically significant increases in BMI among the CG participants and the IG participants, who were underweight, which led to more BMI rises that were not significant than the CG participants but not significant differences were not significant. In addition, we discovered a significant rise in continuously measured BMI among the participants who were underweight and at 12-month FU, as well as significant changes in disordered eating habits and behaviors. In the IG, the incidences of new-onset eating disorder symptoms were lower than in the CG, and the decreases in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, were higher in the IG than in the CG," at all time points.
Source link: https://doi.org/10.2196/preprints.35947
"Background: Although preventive interventions for eating disorders in general have demonstrated promise, there are some that are missing, particularly those at risk of anorexia nervosa. " Methods We conducted a randomised controlled efficacy trial for women at risk of AN. A total of 168 women with low body mass and high weight issues, high blood pressure, and unhealthy eating habits were recruited from 3 German universities, as well as on the internet and randomized to Student Bodies-AN or a wait-list control group. At 12-month FU in the group of participants that were underweight, the key findings were clinically significant shifts in disordered eating habits and habits, as well as change in BMI. After the procedure, 81. 5% of the women recovered after the operation, and 69% of the women at 12-month FU were not able to report. Results Data were available for 81. 5% of the women after the procedure, and 69% of the women at 12-month FU. The IG participants' Eating Disorder Examination total scores dropped significantly during the 12-month FU, while the CG participants and the IG participants who were underweight had larger clinically relevant increases in BMI than the CG participants, but these differences were not significant. The prevalence of new-onset eating disorder cases in the IG were lower in the IG than in the CG, and the reductions in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, were higher in the IG than in the CG," at all time points.
Source link: https://doi.org/10.2196/35947
"Abstract Background: We characterized the emergence of eating disorder symptoms among adolescent girls who later developed anorexia nervosa, binge eating disorder, and community-recruited adolescents, determining whether prodromal symptoms exacerbated the likelihood of future outbreak of each eating disorder. " In addition, lower-than-expected BMI future AN onset, binge eating, and all cognitive signs predicted future BN onset, weight loss, and all cognitive signs predicted future PD onset were among other common problems. Conclusions: Both compensatory weight-control habits and weight/shape overvaluation often appear before other prodromal signs of all eating disorders during adolescence, according to the study findings. Screening adolescent girls for these prodromal signs and implementing appropriate prevention strategies to prevent future eating disorders may be helpful in preventing future eating disorders from occurring. ".
Source link: https://doi.org/10.1017/s0033291722001568
"Background" is the publication of a journal that published the findings of research aimed at detecting intra-group differences among females suffering from various eating disorders in terms of the subjects' psychological characteristics, the adoption of socio-cultural beliefs, and the rate of body dissatisfaction. Is it possible to distinguish specific profiles of psychological as well as body dissatisfaction, social anxiety, media exposure, and internalization of common body image norms? The following research question was asked: is it possible to distinguish specific profiles of psychological characteristics, as well as measures of body mistrust, socioeconomic status, levels of body sex, as well as body dissatisfaction, social anxiety, and internalization of common body image stereotypes was asked. Result Cluster analysis of the research findings revealed four widely different clusters to be distinguished in the group of 121 examined females suffering from eating disorders. In the next step, variance analysis was used to compare the differences between the two investigated clusters in terms of the investigated variables and their indicators.
Source link: https://doi.org/10.5114/hpr.2015.55169
The clinical neurobiology of anorexia nervosa with respect to state-related and trait-related abnormalities is limited. With clinical remission, there is evidence of restitution of structural brain alterations. We compared women with AN, well-recovered female participants, and non-patients cross-sectionally. To compare neural responses to food and non-food images, functional magnetic resonance imaging was used. Even when using lenient thresholds for the comparison of neural responses, functional responses and affective ratings did not differ between REC and NP.
Source link: https://doi.org/10.1186/s40337-022-00598-7
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