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Animal Model - OSTI GOV

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Last Updated: 27 June 2022

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Amelioration of Alzheimer’s disease pathology and cognitive deficits by immunomodulatory agents in animal models of Alzheimer’s disease

Microgliosis is a form of innate immune stimulation in AD. The few drugs that have been approved by the U. S. FDA for the treatment of AD improve symptoms but do not change the course of disease progression and may have some undesirable side effects. In AD animal model trials, translation of active and passive immunotherapy targeting Au03b2 in AD animal model trials had little success. Both Au03b2 and tau aggregation can cause inflammation-free skin inflammation during the disease process, although not preventive. Multiple agents with immunomodulatory functions that ameliorated AD pathology and cognitive impairment in animal models of AD have been found in the research. In an aged animal model of AD, the results of a combinational therapy involving two or more of the tested pharmaceutical agents, or one of these agents given in conjunction with one of the cell-based therapies should warrant further investigation.

Source link: https://www.osti.gov/biblio/1628700


PhenoDigm: analyzing curated annotations to associate animal models with human diseases

The ultimate aim of modeling model organisms is to turn what is learned into actionable data about normal human biology and disease to facilitate diagnosis and early screening for diseases. When an abundance of phenotype data becomes available, only systematic review will help to draw valid conclusions from these studies and spread to human diseases. Here, we present Phenotype comparisons for DIsease Genes and Models as an automated way to find out about geneu2013disease connections by analyzing phenotype data. PhenoDigm uses data from a variety of model organisms to select only highly reported gene candidates for human genetic diseases at the same time, as well as several intermediate scoring schemes. In addition, we provide information on how to search the data with PhenoDigmu2019s web interface and illustrate its usefulness in supporting research.

Source link: https://www.osti.gov/biblio/1625303


Linking Human Diseases to Animal Models Using Ontology-Based Phenotype Annotation

phenotypes in natural language have long been used by scientists and physicians who investigate genetic mutations and disease. We tested the hypothesis that ontological annotation of disease phenotypes would aid in the discovery of new genotype-phenotype relationships within and across species. We used an Entity-Quality model to describe phenotypes using ontologies, wherein the affected entity and how it is affected are recorded using terms from a variety of ontologies. We annotated the phenotypes of 11 gene-linked human diseases identified in Online Mendelian Inheritance in Man by using this EQ technique. These human annotations were uploaded into our Ontology-Based Database, as well as other ontology-based phenotype descriptions of mutants from various model organism databases. We conclude that an EQ-based annotation of phenotypes, as part of a cross-species ontology, and a variety of similarity measures can help identify biologically significant similarities between genes by comparing phenotypes alone.

Source link: https://www.osti.gov/biblio/1627161

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions