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Angiogenesis Inhibitors - Wiley Online Library

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Last Updated: 27 April 2022

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Myricetin reverses epithelial–endothelial transition and inhibits vasculogenic mimicry and angiogenesis of hepatocellular carcinoma by directly targeting PAR1

Most antiangiogenic inhibitors targeting endothelium-dependent vessels do not prevent tumor formation, but in some patients, tumor formation and metastasis have been seen. Inhibiting VM may be a novel antiangiogenic tactic against alternative tumor vascularization. Myricetin was selected from several flavonoid compounds as an effective PAR1 antagonist in this study. Myricetin inhibited cell migration, and VM formation, and even reversed the expression of epithelial–endothelial transition markers by inhibiting PAR1 expression in two separate hepatocellular carcinoma cell lines by inhibiting PAR1. Knockout of PAR1 decreased HCC cell proliferation and metastasis, and metastasis, and myricetin's inhibitory role on HCC cells was reduced.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/ptr.7427


mTOR inhibition by TAK‐228 is effective against growth, survival and angiogenesis in preclinical retinoblastoma models

TAK228 was less effective at inhibiting cell proliferation and survival in normal retinal and fibroblast cells than retinoblastoma cells under the same experimental conditions as retinoblastoma cells. TAK228 also inhibits retinoblastoma and retinal angiogenesis by inhibiting mTOR signalling, as shown by the previous TAK-228 inhibitors. Both retinoblastoma and retinal endothelial cells have been found to have TAK228 in both retinoblastoma and retinal endothelial cells, according to Rescue studies. In a retinoblastograft mouse model, we demonstrate the inhibitory effects of TAK-228 on tumor and angiogenesis. Our results provide a preclinical justification for investigating TAK 228 as a treatment for retinoblastoma and highlight the therapeutic value of targeting mTOR in retinoblastoma.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/prp2.930

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions