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Angiogenesis Inhibitors - DOAJ

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Last Updated: 27 April 2022

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The impact of histological types on the efficacy of angiogenesis inhibitors in the treatment of advanced NSCLC: a meta-analysis of randomized controlled trials

According to histological origins, we wanted to identify relevant studies and compare angiogenesis inhibitor-containing regimens in the treatment of advanced non-small-cell lung cancer therapy in the treatment of advanced non-small-cell lung cancer treatments by searching PubMed and Web of Science, as well as abstracts published at the American Society of Clinical Oncology's October 31, 2014 meeting to identify relevant studies. When compared to non-AI-containing regimens, AI-containing regimens significantly raised the PFS and OS in lung adenocarcinoma. Conclusion: The findings of this report show that the introduction of AIs to the treatment therapies for patients with lung adenocarcinoma provides enhanced survival benefits.

Source link: https://doaj.org/article/1a2c880d838d46feb27dc21a60b2b72d


Angiogenesis Inhibitors in NSCLC

Angiogenesis is a complex biological process that plays a vital role in maintaining the microenvironment, expansion, and metastatic potential of many tumors, including non-small cell lung cancer. Bevacizumab was the first angiogenesis inhibitor approved for the treatment of patients with advanced NSCLC in combination with chemotherapy; however, it was limited to patients with non-squamous histology and first-line setting. Both trials were based on the findings of two phase III trials that indicated an improvement of about two months in progression-free survival in both trials, as well as a rise in overall survival in both trials. When compared to docetaxel alone, ramucirumab plus docetaxel elevated the median OS of patients with any histology NSCLC. In the LUME-Lung 1 study, nintedanib plus docetaxel raised the median PFS of patients with any tumor histology invasively, as well as enhanced OS in patients with adenocarcinoma.

Source link: https://doi.org/10.3390/ijms18102021


Angiogenesis inhibitors in the treatment of prostate cancer

Abstract Prostate cancer remains a significant public health issue, despite a lack of treatment options in the case of castrate-resistant metastatic disease. In this article, the application of anti-angiogenic therapy to prostate cancer is explored, with particular attention to the efficacy and toxicity of several classes of anti-angiogenic agents. Ultimately, the fate of anti-angiogenic agents in prostate cancer remains unclear as a result of several key phase III studies.

Source link: https://doi.org/10.1186/1756-8722-3-26


Synthesis and biological evaluation of novel N9-heterobivalent β-carbolines as angiogenesis inhibitors

In the Sarcoma 180 and Lewis lung cancer animal models, acute toxicities and antitumor efficacies of the selected compounds in mice were also investigated, and compounds 5b and 5w showed a tumour inhibition rate of over 40%. Assay, testing revealed that compound 5b had apparent angiogenesis inhibitory effects in the chicken chorioallantoic membrane.

Source link: https://doi.org/10.1080/14756366.2018.1497619


The impact of angiogenesis inhibitors on survival of patients with small cell lung cancer

Background: Small cell lung cancer is a common and lethal neuroendocrine disease. Using network metaanalysis, we hoped to obtain a comprehensive review of the effect of angiogenic inhibitors on SCLC survival. RNA sequencing results were downloaded from publicly accessible databases, according to publicly accessible databases. In this meta-analysis, nine phase II and III controlled trials that included 1599 participants and examined angiogenesis inhibitors in the treatment of SCLC were included in this analysis. PFS results on Sun and Bev exceeded Tha's Tha. In addition, Sun and Bev were more effective to placebo in terms of PFS. Conclusion The results of this network meta-analysis show that the PFS results of SCLC with Sun or Bev drugs is superior to that of Tha. To be valid, the improved therapeutic effect of angiogenesis inhibitors on SCLC must be documented by more evidence, such as long-term observation in clinical trials.

Source link: https://doi.org/10.1002/cam4.2462


Murine experimental autoimmune encephalomyelitis is diminished by treatment with the angiogenesis inhibitors B20-4.1.1 and angiostatin (K1-3).

In order to find novel therapeutic targets, angiogenesis is the production of new blood vessels from pre-existing vasculature that contributes to inflammatory conditions of the Central Nervous System. K, the first three kringle domains of angiostatin, was specifically targeted at during angiogenesis. At day 21, T cell infiltration into the spinal cord was unaffected by either therapy. The T helper-17 cell cytokine interleukin-17 cell cytokine interleukin -17 cell cytokine interleukin -17 cell cytokine interleukin -17 cells from mice treated mice had reduced amounts of the T helper-17 cell cytokine interleukin -17 with no effect on the Th-1 cytokine interferon - or Th-2 cytokine IL-4. However, when either drug was added in vitro to naive T cells or to antigen stimulated T cells from mice with untreated EAE, they had no effect on proliferation or IFN-. These angiogenesis inhibitors, we'll conclude, counter EAE by both suppressing spinal cord angiogenesis and minimizing peripheral T cell activation.

Source link: https://doi.org/10.1371/journal.pone.0089770


Cancer combination therapies by angiogenesis inhibitors; a comprehensive review

Abstract Abnormal vaping is one of tumor tissue's most noticeable features, with a large portion of tumor cell evasion contributing to tumor immune evasion. Owing to this fact, angiogenesis blockade therapy was developed to combat cancer by limiting the nutrient and oxygen supply to the malignant cells by impairing the vascular network. Given the predominant role of vascular endothelium growth factor in the angiogenesis process, the most effective anti-angiogenic agents mainly depend on the target of its actions. Following their administration, cancer cells have mainly demonstrated resistance to anti-angiogenic agents by many methods, but also potentiated local invasiveness, and even distant metastasis have been reported.

Source link: https://doi.org/10.1186/s12964-022-00838-y


Marine-Derived Angiogenesis Inhibitors for Cancer Therapy

Angiogenesis inhibitors have been used in the clinic and have been used for cancer therapy. This report will include an overview of the latest marine-derived angiogenesis inhibitors, as well as their primary goals and/or mechanism of action. Then, the marine-derived antiangiogenic protein kinase inhibitors, will be the subject of the study.

Source link: https://doi.org/10.3390/md11030903


ANGIOGENESIS INHIBITORS FOR THE TREATMENT OF HEPATOCELLULAR CARCINOMA

Background: Angiogenesis inhibitors have emerged as a vital therapeutic strategy in the treatment of hepatocellular carcinoma patients. Angiogenesis, a fundamental component of HCC care, can be delayed by Sorafenib's success in extending overall survival of patients with HCC. The combination of antiangiogenic drugs, radiotherapy, or other targeted drugs has been evaluated in light of the heterogeneous features of HCC, including the ability to raise therapeutic efficacy, reduce drug resistance, and minimize toxicity. Conclusion: Large investments in the clinical study are required to enhance treatment efficiency and minimize hazards for patients with HCC.

Source link: https://doi.org/10.3389/fphar.2016.00428

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions