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Angina - PubAg

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Last Updated: 16 October 2021

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Oxidised LDL and Anti-Oxidised LDL Antibodies Are Reduced by Lipoprotein Apheresis in a Randomised Controlled Trial on Patients with Refractory Angina and Elevated Lipoprotein(a)

The purpose of this study was to examine the impact of LA on oxLDL and anti-oxLDL degrees amongst those with refractory angina in the context of raised Lp. Approaches: We did a sub-study within a randomised regulated crossover test involving 20 patients with refractory angina and raised Lp > 500 mg/L, contrasting the result of 3 months of blinded weekly LA or sham, adhered to by crossover to the contrary research study arm. Outcomes: Following three months of LA, there was a 30% reduction in oxLDL from 0. 37 ± 0. 06 to 0. 26 ± 0. 04 with a mean drop of -0. 11 units contrasted to no significant modification with sham therapy. Conclusion: Amongst patients with refractory angina in the context of raised Lp, LA dramatically lowers levels of oxLDL and anti-oxLDL antibodies, representing potential mechanisms by which LA returns symptomatic and prognostic advantages in this patient friend.

Source link: https://pubag.nal.usda.gov/catalog/7244126


Clinical effectiveness and safety of salvia miltiorrhiza depside salt combined with aspirin in patients with stable angina pectoris: A multicenter, pragmatic, randomized controlled trial

Salvia Miltiorrhiza Depside Salt was drawn out from Salvia miltiorrhiza with premium control of active principles. In 2005, China's FDA authorized making use of SMDS for secure angina pectoris, but the proof of SMDS incorporated with pain killers remains unclear. The goal of this research was to assess the scientific efficiency and safety and security of SMDS incorporated with aspirin in patients with SAP. A multicenter, practical, three-armed identical group and an independently randomized controlled supremacy trial was created. Participants aged 35 to 75 years old with SAP were recruited from four "Class Grade A" health centers in China. Individuals that were randomized into the SMDS team were treated with SMDS by intravenous drip. Participants in the SMDS combined pain killers group had the highest renovation rate of level of sensitivity in AA% [p < 0. 001, 95% CI], from 30. 6% before treatment to 81. 6% after treatment. Participants with medicine resistance in the SMDS integrated with aspirin team had the highest sensitivity rate [p < 0. 001, 95% CI] after treatment. The renovation of TCM signs in participants treated with SMDS integrated with pain killers was considerably better than that of the aspirin group [MD = 1. 71, 95% CI, p = 0. 032] No blood loss tendency or ADRs happened in all participants. SMDS combined with pain killers is a safe and medically efficient treatment to treat adults aged 35 and older with SAP. This trial shows that SMDS integrated with aspirin can substantially improve the sensitivity rate of AA% in TEG and the VAS rating of TCM signs.

Source link: https://pubag.nal.usda.gov/catalog/7206225


Network pharmacology-based therapeutic mechanism of Kuanxiong aerosol for angina pectoris

Kuanxiong aerosol has been reported to be a risk-free and effective scientific treatment for angina pectoris. To discover the prospective pharmacological mechanism of Kuanxiong aerosol by combined methods of network pharmacology forecast and experimental verification. Networks of Kuanxiong ap-related genes and aerosol-associated targets were created via STRING data source. Several pathways, such as the hypoxia-inducible aspect 1 and lump necrosis factor paths were found to be very closely associated to the medicinal safety mechanism of Kuanxiong aerosol against AP. Kuanxiong aerosol can attenuating heart fibrosis and improving cardiac function in a cardiac fibrosis rat model. This study revealed that the pharmacological mechanisms of Kuanxiong aerosol for AP therapy were connected to anti-myocardial ischemia, anti-inflammation, and anti-oxidation using a non-hemodynamic way, suggesting that Kuanxiong aerosol is a better drug medically for AP treatment because of its both protective and preventative results.

Source link: https://pubag.nal.usda.gov/catalog/6985924


Mentha longifolia alleviates experimentally induced angina via decreasing cardiac load

Here, the feasible antianginal result of Mentha longifolia remove was researched in speculative version of angina. Aerial parts of M. longifolia were extracted, standardized, and offered to rats 3 days before angina. M. longifolia extract significantly alleviated the continual decrease in cardiac contractility after vasopressin exposure. M. longifolia did not affect the damaged heart dilation after vasopressin. Heart rate was dramatically reduced after vasopressin exposure in rats treated with M. longifolia compared with unattended pets. Furthermore, M. longifolia produced even more boost in diastolic and systolic durations after vasopressin exposure compared to untreated pets. USEFUL APPLICATIONS: The present study is the first to research the impact of M. longifolia in an experimental model of angina. M. longifolia alleviated the damaged cardiac contractility connected with angina exposure. The antianginal effect of M. longifolia could be via decreasing cardiac load.

Source link: https://pubag.nal.usda.gov/catalog/6305697


Investigating the multi-target pharmacological mechanism of danhong injection acting on unstable angina by combined network pharmacology and molecular docking

BACKGROUND: Danhong shot, which is just one of the most popular Traditional Chinese Medicine shots, extensively used to treat unsteady angina. After that, we developed the UA target database by DisGeNET, DigSee, TTD, OMIM. OUTCOMES: The results showed that 12 ingredients of DHI and 27 alleged well-known healing targets were chosen. FINAL THOUGHT: The outcomes of this research study preliminarily clarified the possible targets and signaling paths of DHI in the treatment of UA, which may help to laid a good foundation for experimental research study and more clinical application.

Source link: https://pubag.nal.usda.gov/catalog/6853855


Dietary choline is related to increased risk of acute myocardial infarction in patients with stable angina pectoris

However, nutritional choline is not associated with choline plasma focus, and there are few studies and inconsistent evidence pertaining to nutritional choline and cardiovascular occasions. On top of that, an advised dietary allowance for choline has not been established and remains a point of contention. This research analyzed the association between nutritional choline, including choline types, and danger of incident acute myocardial infarction in patients with suspected stable angina pectoris. In total 1981 patients from the Western Norway B Vitamin Intervention Trial were consisted of in this evaluation. Details on dietary choline was gotten making use of a 169-item food regularity survey. Danger associations were approximated utilizing Cox-regression analysis using energy-adjusted choline intake. Median total energy-adjusted choline consumption was 288 mg/d. Increased intakes of energy-adjusted choline, phosphatidylcholine and sphingomyelin were related to higher AMI risk. In verdict, higher dietary intakes of complete choline, phosphatidylcholine and sphingomyelin were related to boosted danger of AMI in patients with SAP.

Source link: https://pubag.nal.usda.gov/catalog/6761633


Dietary composition is associated with one-carbon metabolites and B-vitamin status in patients with stable angina – a cross-sectional study

homocysteine and dimethylglycine, have been linked with increased cardio disease risk. Diet plan can affect one-carbon metabolism, and this may partially be mediated with transformed PPARα activity as dietary fats can trigger PPARα. As diet is a flexible life style variable, the aim of this examination is to discover possible organizations between nutritional structure and plasma focus of one-carbon metabolites and pens of B-vitamin condition. The research study population contained 1977 patients with steady angina from the Western Norway B-vitamin Intervention Trial, that finished a self-administered food frequency set of questions at standard. The average distribution [95% prediction period] of energy consumption in the population was 48. 5 from carb, 31. 4 from fat and 16. 5 from healthy protein. The existing observations indicate that nutritional macronutrient structure may influence plasma focus of one-carbon metabolites and pens of B-vitamin standing.

Source link: https://pubag.nal.usda.gov/catalog/6982191


PPARA, PPARD and PPARG gene polymorphisms in patients with unstable angina

Among patients there was the increased frequency of CG and GG genotypes and G alleles. The organization between PPARG rs1801282 G allele and unpredictable angina was verified in multivariate regression analysis. There were no statistically substantial differences in the distributions of various other studied polymorphisms between patients with unpredictable angina and the control group. The outcomes of our research recommend the association between PPARG rs1801282 G allele and unsteady angina in Polish population.

Source link: https://pubag.nal.usda.gov/catalog/6484108


Corn silk decoction for blood lipid in patients with angina pectoris: A systematic review and meta‐analysis

The goals of this study were to review the efficacy of corn silk decoction on lipid account in patients with angina pectoris. PubMed, Cochrane, Embase, Google Scholar, Chongqing VIP Chinese Science and Technology Periodical Database, China National Knowledge Infrastructure, and Wanfang database were looked up to January 2019 for randomized regulated tests that evaluated the impact of corn silk decoction on complete cholesterol, triglycerides, low‐density lipoprotein cholesterol, and high‐density lipoprotein cholesterol in patients with angina pectoris. An overall of 4 randomized regulated tests were eligible for meta‐analysis. Pooled results of these studies indicated that corn silk preparation could enhance high‐density lipoprotein cholesterol and minimize overall cholesterol, triglycerides, and low‐density lipoprotein cholesterol in patients with angina pectoris. Subgroup analyses revealed that corn silk decoction or changed corn silk decoction plus traditional pharmaceutical treatment could have beneficial impacts on blood lipids.

Source link: https://pubag.nal.usda.gov/catalog/6752036


Clinical metabolomics analysis of therapeutic mechanism of Tongmai Yangxin Pill on stable angina

Tongmai Yangxin Pill is a typical Chinese medication for the treatment of angina and arrhythmia. In this study, we assessed lotion samples of medical patients collected from 7 various clinical units in China after oral administration of TMYX utilizing ultra-performance fluid chromatography quadrupole time-of-flight mass spectrometry. Numerous analytical analysis including major component analysis and partial the very least square discrimination analysis, were made use of to examine metabolite profile adjustments in serum examples. After TMYX treatment, 10 biomarkers were turned around to the typical conditions. These outcomes recommended that TMYX exerted restorative results by improving myocardial energy supply condition and amino acid disorder, and attenuating oxidative anxiety and swelling. The here and now study, as the first multicenter medical study which reveals the molecular biological basis and restorative mechanism of TMYX on secure angina, can give objective indicators for efficiency evaluation of TMYX on stable angina.

Source link: https://pubag.nal.usda.gov/catalog/6162979

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions