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Endothelial dysfunction exacerbated by oxidative stress plays a significant role in the development of vasospastic angina pectoris. Glutamate causes endothelial dysfunction by producing oxidative stress, and it blocks cystine import into endothelial cells by the cystine/glutamate antiporter, which leads to oxidative depletion of antioxidant glutathione. With VSAP, we investigated plasma glutamate and cystine levels, antioxidant stress markers, and antioxidant capacity in non-smoker patients to see if glutamate and cystine are related to the development of VSAP. Plasma glutamate and cystine values were both significantly higher in the group with, than without VSAP. In patients with VSAP who did not smoke, plasma glutamate levels were elevated, and they were positively connected with plasma cystine and negatively associated with low biological antioxidant potential measurements.
Source link: https://europepmc.org/article/MED/35695518
Background Plaque healing can play a vital role in the natural progression of atherosclerotic disease. In this research, the aim was to determine predictors and morphological characteristics of healed plaque among angina pectoris patients. Patients who were involved with AP and underwent pre-intervention optical coherence tomography imaging were sequentially selected for this single-center retrospective observational study. In 186 patients, HP was found in unstable angina pectoris and was less prevalent in cases of chronic angina pectoris than in stable angina pectoris. Higher incidences of previous myocardial infarction and SAP were found within the HP group, as well as higher triglycerides and uremia. In HP lesions, UAP patients had more plaque ruptures and thrombosis, while SAP patients had lower uric acid levels and more multiple HPs, while SAP patients had lower uric acid levels and more multiple HPs. Conclusions with AP In patients with AP, the clinical presentation of SAP and long lesion lengths were solid predictors of HP.
Source link: https://europepmc.org/article/MED/36072996
Background: The effectiveness of Yangxin Decoction in the treatment of coronary heart disease patients with angina pectoris was determined by this research. Included in the research were randomized controlled trials of YXD in the treatment of AP in patients with CHD. The meta-analysis findings revealed that YXD significantly raised the response rate of AP and the response rate based on the electrocardiogram, as well as drastically reduced the use of nitroglycerins, according to the investigators. Conclusions: The results of this study indicated that YXD was safe in the care of patients with AP of CHD.
Source link: https://europepmc.org/article/MED/PMC9439739
Aims The pre-test result is a key gatekeeper in choosing patients for coronary artery disease diagnostic testing. The 2019 European Society of Cardiology guidelines recommend upgrading PTP based on medical risk factors, but no figures on how these changes influence PTP. Methods and findings In 42 328 patients u226530 years old without prior CAD, with no previous CAD referred to cardiac computed tomography angiography in a region of Denmark from 2008 to 2017. The ESC 2019 PTP and basic model included angina signs, sex, and age, as well as diabetes mellitus family history of CAD and dyslipidaemia. The clinical and basic models were well calibrated, while the ESC 2019 PTP underestimated CAD prevalence, with the clinically relevant low estimated probability u22645% of CAD cut-off.
Source link: https://europepmc.org/article/MED/35575616
The present research examined the clinical results of angiotensin-converting enzyme inhibitor or angiotensin receptor blocker therapy in patients with unstable angina with preserved left ventricular systolic function who underwent percutaneous coronary intervention due to uncertainty regarding the long-term prognosis using ACEI or ARB. In conclusion, prognoses in UA patients who had retained left ventricular systolic function after PCI were similar between ACEI or ARB therapy.
Source link: https://europepmc.org/article/MED/36039598
Background Vasospastic angina is a result of severe diffuse or segmental coronary artery spasms. Patients with variant angina have poor health outcomes, but nitrates and calcium blockers can help patients improve patient conditions because there is no knowledge of the cause or causal treatment. Patients and methods VSA 109 patients were diagnosed with acute myocardial infarction, typical electrocardiography, and coronary angiography were recruited, and 61 patients with acute myocardial infarction and coronary artery stenosis were recruited as controls, with 109 patients diagnosed as controls. In addition, four patients with VSA underwent 18-fluorine fluorodeoxyglucose positron emission tomography/computed tomography. In all four patients, the left ventricle, coronary perivascular tissue volume, and coronary perivascular FDG uptake were all significant. VSA patients have significant plasma cytokine levels and myocardial and pericoronary inflammation, which may be explained by myocardial and pericoronary inflammation, according to myocarditis.
Source link: https://europepmc.org/article/MED/36060213
Aims The aim of this study was to determine whether 10-year anginal status of patients with left main coronary artery disease and/or 3-vessel CAD had the same effect as percutaneous coronary bypass graft in patients with left-main coronary artery disease and/or 3-vessel CAD. Methods and findings In this post-revascularization study after revascularization with PCI or CABG, patients were classified as having persistent angina if they self-reported Seattle Angina Questionnaire angina frequency scale, causing a slew of angina at 1-year follow-up. The main endpoint of all-cause death in ten years was compared between the RA and no-RA groups. Conclusions Among patients with LMCAD and/or 3VD revascularization at 1-year post revascularization were independently associated with repeat revascularization at 5 years, but it did not rise 10-year mortality, irrespective of the primary mode of revascularization.
Source link: https://europepmc.org/article/MED/36001991
Methods Clinical physicochemical tests are useful in disease diagnosis, but they are often not used enough in the process of TCM syndrome differentiation. In blood stasis patients, there were significant differences in HGB, PLT, Pt, PTA, Na +, PRT, PTA, Na +, TG, LDL, BNP, LVEDd, and EF. In qi depression patients compared to non-qi depression patients, there were significant differences in atpp, TG, LDL, LVESD, and FS. Conclusion The combination of physical and chemical measurements obtained from the neural network model provides a clinical reference base for identifying the syndrome factors of chronic angina pectoris patients with anxiety, such as blood stasis, yin deficiency, phlegm turbidity, and qi stagnation.
Source link: https://europepmc.org/article/MED/36045947
It has been suggested that mixing oral Chinese patent medicines with Western medicine could have a greater effect than WM alone. To perform network meta-analysis, we also used R 4. 1. 2 and STATA 14. 0 software packages, followed by sensitivity and subgroup analysis. OCPMs mixed with WM had a greater therapeutic effect than WM alone, according to WM. Seekinghen Zhuyu capsule +WM, Shensong Baoxin capsule +WM, Tongxin capsule +WM, Tongxin capsule +WM, Tongxin capsule +WM, Naoxintong capsule +WM, Fufang dripping tablet +WM, Fufang Zixin capsule +WM, Tongxin capsule +WM, Tongxin capsule +WM, Tongxin capsule +WM, Tongxin capsule +WM, Tong capsule +WM, Tong capsule +WM, Shen capsule +WM, Tong Baoxin capsule +WM, Tongxin capsule +WM, Tongxin capsule +WM, Tongxin capsule +WM, Tongxin capsule +WM, Tongxin capsule +WM, Tongxin capsule +WM, Tongxin capsule +WM, Tongxin capsule +WM, Tongxin capsule +WM, Tongxin capsule +WM, Tongxin capsule +WM, Tongxin capsule +WM, Tongxin capsule +WM, Tongxin capsule +WM, Tongx Regarding the effective rate in ECG, QSYQ + WM was superior to SXBX + WM, TXL + WM, FFDS + WM, and NXT + WM, with QSYQ+ WM being the most advanced to SXBX + WM, TXL + WM, MM, FFDS + WM, and NXT + WM. QLQX + WM, QLQX + WM, QLQX + WM, QLQX + WM, and TXL + WM had a better result than FFDS + WM, Kuanxiong aerosol +WM, WM, FFDS + WM, QLQX + WM, SXBX + WM, TXL + WM, and TXL + WM in terms of Xiong Regarding the duration of an angina attack, KXQW + WM was more effective than SSYX + WM; KXQW + WM came first; WM, KXQW + WM ranked first; KXQW + WM came in first. DL + WM had the most effect compared to the cardiovascular event rate. In addition, SSYX + WM had the lowest incidence of adverse drug reactions. Conclusion: OCPMs as well as WM had a higher success rate. According to SXBX + WM, the most commonly recommended treatment regimen for both clinically efficient and cardiovascular event rates.
Source link: https://europepmc.org/article/MED/36059992
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