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Angelman syndrome is a complex genetic disorder that predominantly affects the nervous system. Recurrent seizures and a small head size are also present in the majority of the affected children. Children with Angelman syndrome have a positive, excitable demeanor with frequent smiling, joking, and hand-flapping movements. Also, most impacted children have trouble sleeping and require less sleep than average. People with Angelman syndrome become less active as age, and sleeping difficulties tend to increase. Adults with Angelman syndrome have distinctive facial features that can be described as "coarse. ".
Christianson syndrome is a condition that mostly affects the nervous system. Individuals who do learn to walk lack the skills of walking in childhood. Beginning around ages 1 and 2, the majority of the affected children also have recurrent seizures.
Prader-Willi syndrome is a complex medical disorder that affects multiple organs of the body. Symptoms in childhood and adult obesity contribute to a constant overeating and obesity. Type 2 diabetes also affects some people with Prader-Willi syndrome, especially those with obesity. People with Prader-Willi syndrome have mild to moderate cognitive impairment and learning difficulties. Sleep disorders can also occur. People with Prader-Willi syndrome have unusually fair skin and light-colored hair. Both affected males and females have underdeveloped genitals. Puberty is delayed or ineffective, and the majority of those affected are unable to have children.
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