Anabolic Steroids - Crossref

Interdisciplinary and Psychiatric Treatment of Anabolic Androgenic Steroids Users

The prevalence of anabolic androgenic steroids use in recreational sports is underestimated. Patients may be able to obtain the assistance they need from primary care providers with the help they require. Harm reduction plans may be able to assist patients.

Source link: https://doi.org/10.1024/1661-8157/a003868

The Buzz about Anabolic Androgenic Steroids: Electrophysiological Effects in Excitable Tissues

Although the signaling pathways by which the AAS administers both beneficial and harmful activities are likely to include ligand-gated and voltage-dependent ion channels that regulate the production of electrically excitable tissue. We review the known effects of AAS on molecular targets that play significant roles in regulating electrical activity, with a particular emphasis on the effects of AAS on neurotransmission mediated by GABA A receptors in the central nervous system.

Source link: https://doi.org/10.1159/000339123

Treatment of Idiopathic Short Stature: Effects of Gonadotropin-Releasing Hormone Analogs, Aromatase Inhibitors and Anabolic Steroids

Modulation of sex steroid activity on the growth plate can, at least theoretically, raise adult height in children and adolescents with idiopathic short stature. Accordingly, GnRH analogs are no longer used to increase height in adolescents with short stature and commonly timed puberty. Aromatase inhibitors are more effective than GnRH equivalents in boosting adult height in children with short stature, and unlike GnRH analogs, they do not delay pubertal growth in males. There are no studies demonstrating the positive effects of anabolic steroids on adult height.

Source link: https://doi.org/10.1159/000330150

Impact of Health Authority Control Measures Aimed at Reducing the Illicit Use of Anabolic-Androgenic Steroids

In retail pharmacies, two experiments on anabolic-androgenic-steroids dispensation were used. The research was carried out in a north-western region of Spain's north-western region. The AAS were supplied by wholesale drug manufacturers to retail pharmacies over a 102 month period. Both interventions were tested: an inspection scheme aimed at those retail pharmacies where an irregular dispensation was not present, and a law requiring these pharmacies to maintain additional registers were determined. stanozolol, nandrolone, methenolone, testosterone, and mesterolone were among the medications tested. AAS' pre-intervention use of AAS continued to rise. stanozolol and nandrolone were two of the most commonly used medications, according to the most. Conclusion: The health initiatives were highly fruitful, in the sense that they resulted in a dramatic decrease in the illicit use of AAS. These actions could be used to other drugs in which abuse was suspected.

Source link: https://doi.org/10.1159/000486852

Anabolic Androgenic Steroids in the General Population: User Characteristics and Associations with Substance Use

lifetime users of AAS were compared to all nonusers and to nonusers who reported that they had been provided AAS in hierarchical logistic regression studies. AAS users were distinguished from non-users who had been given AAS by illicit drug use and misappropriation of prescription drugs. Conclusions: In this general population survey in men, lifetime use of AAS appears to have common characteristics with illicit drug use. When determining for one another, both substance use variables and physical fitness remained linked with AAS use.

Source link: https://doi.org/10.1159/000333037

Is There an Association between the Use of Anabolic-Androgenic Steroids and Criminality?

AAS users' AAS-related problems at a psychiatric addiction clinic in Sweden were treated according to the study, based on interviews and criminality reports. After being introduced to opioids, the criminal use level of 69% of the participants increased for 69%. Conclusion: The results indicate that there is an association between AAS and criminal justice, particularly in the case of violent assault and firearms charges, and that criminal convictions may be enhanced if AAS are combined with other drugs of abuse.

Source link: https://doi.org/10.1159/000320286

Multisubstance Use as a Feature of Addiction to Anabolic-Androgenic Steroids

The purpose of this study was to investigate and report complete drug use among anabolic-androgenic steroid users and the reasons for using these medications. The most common reason for taking AAS and other hormones was to increase muscle mass and strength, but some participants also used insulin as a way of losing fat. Multiple drug users with polysubstance dependence are among the current AAS users who have been accepted to a treatment program, according to Our findings.

Source link: https://doi.org/10.1159/000199045

ADHD symptoms and use of anabolic androgenic steroids among male weightlifters

We wanted to see if AAS use in male weightlifters was related to ADHD symptoms, as well as test the correlation between ADHD symptoms and cognitive outcomes. The Achenbach system of empirically based diagnosis of ADHD symptoms, as well as cognitive testing, included four male weightlifters, 72 AAS users, and 68 weightlifting controls. Self-reported ADHD symptoms were significantly higher among AAS users than WLC, and diagnoses indicating clinically relevant ADHD were significantly higher in the AAS-using population. Recognizing a connection between ADHD symptoms and AAS use may help with drug management in sports.

Source link: https://doi.org/10.1038/s41598-022-12977-w

Simultaneous Analysis of Sexual Stimulants and Anabolic Steroids as Adulterants in Dietary Supplements by High Performance Liquid Chromatography with Photodiode Array Detection

Background: The illicit online market for food supplements promotes theft and adulteration. Consumer safety is on the rise worldwide, as are enforcement departments, physicians, and consumers. This research sought to determine the presence of sexual stimulants and anabolic steroids commonly used in the adulteration of dietary supplements by the introduction of a high performance liquid chromatography with photodiode array detection for the detection and quantification of these compounds. Method: The mobile phase, which consisted of an ammonium acetate solution, acetonitrile, and methanol, led to the successful separation of vardenafil, testosterone propionate, testosterone propionate, tadalafil, sildenafil, and yohimbine. Adulterents in four studies of dietary supplements were testosterone, tadalafil, and yohimbine. Since over 80% of adverse drug reactions are dose dependent, unpredictable adverse drug reactions are dose independent and based on idiosyncratic or allergic mechanisms or intolerance.

Source link: https://doi.org/10.2174/1573412916999200415175325

Medaka embryos as a model for metabolism of anabolic steroids

Abstract: The knowledge of drug metabolism in anti-doping science is a prerequisite for the identification of misused banned substances. We investigated whether Oryzias latipes embryos could be an alternative, non-animal test model to investigate human-like metabolism in the present study. We exposed medaka embryos at the morula stage to the anabolic steroid metandienone for a period of 2 to 8 days in the present study. We investigated the embryos' developmental status according to the fish embryo toxicity test. Metandienone metabolites were further investigated by high-performance liquid chromatography- and gas chromatography-mass spectrometry. For the introduction of the 50-u00b5M metandienone, developmental abnormalities were found, though a significant rise in the heart beat was also present in those people exposed to the lower dose for 8 days. The medaka embryo, according to the present study, is a promising model to investigate human-like metabolism.

Source link: https://doi.org/10.1007/s00204-022-03284-4

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