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Anabolic Steroids - ClinicalTrials.gov

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Last Updated: 01 July 2022

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Investigating the Anabolic Response to Resistance Exercise During Critical Illness: The ARTIST-1 Randomized Controlled Trial

The ICUAW affects up to 70% of ICU patients and is the most common with higher illness severity. Resistance training and amino acid ingestion, according to studies in exercise physiology, have synergistic effects on muscle protein synthesis in healthy individuals. Only a few studies in this field investigate muscle structure or cellular signaling in response to training. However, the gold standard in determining anabolic reaction to exercise is to specifically measure protein synthesis and breakdown. In comparison to amino acid supplementation and routine physiotherapy alone, the investigators hypothesize that resistance exercise, rather than amino acid supplementation and routine physiotherapy, results in an improved muscle protein balance in ICU patients. Secondary outcome measures will be evaluated as secondary outcome measures, and the effects of the intervention on other aspects of muscle protein kinetics and within-group differences in protein kinetics and within-group differences in protein kinetics before and after physiotherapy will be assessed.

Source link: https://clinicaltrials.gov/ct2/show/NCT05197231


Investigating the Anabolic Response to Resistance Exercise After Critical Illness: The ARTIST-2 Non-Randomized Controlled Trial

BACKGROUND The debilitating effects of critical illness have been known for many decades. Disability related to intensive care is now described as a condition of ICU-acquired weakness. ICUAW affects up to 70% of ICU patients and is the most common with higher illness severity. It can also be difficult to regain muscle mass during convalescence. Muscle atrophy only in a minority of ICU survivors six months after ICU discharge, according to a small observational study. Resistance training and amino acid ingestion, according to scientific reports in exercise physiology, have synergistic effects on muscle protein synthesis in healthy subjects. Following several clinical studies, there is uncertainty about the benefits of exercise in improving physical function in-ICU-ICU after ICU release. However, the gold standard in determining anabolic reaction to exercise is to measure protein synthesis and breakdown directly. There is currently no published study that uses this approach to investigate the effects of exercise interventions in former ICU patients. The investigators intend to investigate the anabolic consequences of resistance training after critical illness to figure out the role of physical activity in regaining muscle mass. Aim and hypothesis The aim of this study was to determine the anabolic response to resistance exercise after a critical illness. After an ICU stay as compared to non-critically ill controls, the investigators hypothesize that research subjects recovering from critical illness have an impaired anabolic response to resistance exercise after ICU stay.

Source link: https://clinicaltrials.gov/ct2/show/NCT05261984


The Efficacy of a Non-Invasive 13CO2 'Breath Test' to Detect Anabolic Resistance Following Step Reduction in Younger and Older Adults

The aim of this report is to determine differences in whole-body leucine oxidation and leucine net balance among younger and older adults under conditions of regular consumption/step-reduction. Introduction Methods: The full participant time commitment will span over four sessional dates: Session 1 - Introduction : Participants will be invited to participate in a video conference call in order to attend an introductory session. Participants in Session 2 - Body Composition Assessment Participants will take a bolus of deuterium oxide and saliva samples in order to determine the fat-free mass. Habitual Activity Participants will be asked to participate in their normal daily lifestyle habits when wearing an accelerometer and pedometer during Phase 1 - Habitual Activity Participants will be encouraged to participate in their regular daily routine while wearing an accelerometer and pedometer. Metabolic Trials - Habitual Activity Metabolic Trial Following three days of regular routine, participants will be exposed to the non-invasive 13CO2 breath-test to determine for whole-body leucine oxidation and net balance on the morning of the fourth day. Participants will be encouraged to maintain their healthy eating habits and monitor their diet, but will be required to adhere to a reduced daily step count. Step-Reduction Metabolic Trial, Step-Reduction The 7th day of the 7th day of the week following three days of reduced daily step-count, participants will be exposed to the non-invasive 13CO2 breath-test to determine for whole-body leucine oxidation and net balance.

Source link: https://clinicaltrials.gov/ct2/show/NCT05216809

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions