Advanced searches left 3/3

Alzheimer's Disease - Wiley Online Library

Summarized by Plex Scholar
Last Updated: 14 May 2022

* If you want to update the article please login/register

Mixed Cerebrovascular And Alzheimer’s Type Pathology Mimicking Lewy Body Disease And Its Possible Contribution To the Increased Risk of Developing Cognitive Impairment In Elderly Patients with Bipolar Disorder/Schizophrenia

Since it has been previously reported that bipolar disorder, as compared to other common adult psychiatric disorders, is linked to an elevated risk of experiencing Parkinson's disease, cerebrovascular disease, and dementia in later life. For schizophrenia, the same as BD elevated risk of developing dementia was also found for schizophrenia. Surprisingly, Alzheimer's disease, was absent in elderly BD patients with cognitive impairment when AD was investigated by its unique biomarkers in the cerebrospinal fluid. These findings, together, show that AD may have contributed to the increased risk of dementia in elderly patients with BD. Overall, the severity of the respective Alzheimer's type pathology in D1 brain could vary depending on its clinical situation, from mild to moderate. Some blood vessels in the vessel wall and lumen showed amyloid deposits, which is typical of amyloid angiopathy. The AD pathology was also present in the hippocampus and cortex as shown by NFTs and GVD, and it was followed by mild neuronal abnormalities in the hippocampus and cortex. i AD could be present in elderly BD/SCZ patients and may progress to a clinical stage associated with cognitive impairment. It is believed that ii CVD in conjunction with AD could mimic Lewy Body Disease and increase the risk of dementia in older BD/SCZ patients. iii A correct diagnosis of dementia in elderly patients with mixed CVD/AD pathology in BD/SCZ will be helpful to ensure proper treatment and care.

Source link: https://onlinelibrary.wiley.com/doi/10.1096/fasebj.2022.36.S1.0R425


Cerebral Vascular Density and Its Possible Correlation with Alzheimer Disease Progression in Elderly Individuals with Rheumatoid Arthritis

Specifically in RA patients, high amounts of inflammatory cytokines are present in both synovial fluid and serum. Banning reduced BBB stability in a RA animal model has been shown to influence amyloid beta peptide transporter in the peripheral circulation and the brain, thus encouraging A accumulation in the cerebral vasculature and endothelial cell degeneration. Two male cadavers' cerebral cortex and hippocampus were assessed by using a newly developed British vein contrast agent in conjunction with standard histological methods for postmortem evaluation of CVD and pathology in the cerebral cortex and hippocampus. The first, 74-year-old was diagnosed with RA and AD, while the second, 90-year-old, had RA and AD, though the second, 90-year-old had RA and AD. The results revealed that scans of the cerebral cortex from D2, specifically the middle frontal, inferior parietal, and superior temporal gyri, had significantly less mean Hounsfield unit densities than those from the same areas of D1. According to the lower MHUD count in the D2 cortex in comparison to the D1 most likely, it indicates a reduced vascular density in the respective brain region. In D1, the AD diagnosis was confirmed by the D1 diagnosis and revealed distinct AD pathology in D2. ii The vascular density in elderly people with RA's cerebral cortex may be correlated with AD progression. iii The adaption of the published CT imaging procedure for its use in live individuals may be a more accurate and reliable method for determining AD in RA patients at the early AD stages.

Source link: https://onlinelibrary.wiley.com/doi/10.1096/fasebj.2022.36.S1.L6386


Biomarkers Indicative of Late Stage Alzheimer’s Disease Found in the Brain and Retina

Results were two cadavers without a history of neurodegenerative disease and four cadavers affected by AD. When compared to normal cadavers, Retina samples of AD cadavers demonstrated a statistical significance rise in the OD of the TT marker. Only the TT markers in PFC were found to have statistically significant increases in OD values, despite brain tissue structure. In several brain regions of the AD cadavers, TT, PT181, PT205, and BA also showed modest changes in OD in several brain regions, but not enough to be statistically significant. Conclusion There is a significant increase in the TT marker in the retina, despite similar findings in the PFC. This suggests that using TT as a marker in the PFC and retina has the most promise to assist in diagnosing AD, with the possibility of investigating AD progression through TT in various areas of the brain in future research.

Source link: https://onlinelibrary.wiley.com/doi/10.1096/fasebj.2022.36.S1.L7448


Bioactive Steroid Marinobufagenin in a Mouse Model of Early‐Stage Alzheimer's Disease

In 16mo old double transgenic APPswe/PS1dE9 AD mice with advanced AD, amyloid precursor protein, and interleukin 6 mRNAs were upregulated relative to wild type controls, and treatment with MBG reduced mRNA expression. We investigated whether administering MBG at an early stage AD can have an effect on AD development in this AD mouse model. Methods Five months old male AD mice and WT mice were given MBG or a wire for control by ALZET osmotic minipumps for three months. WT&C and AD-C mice had similar plasma MBG levels compared to previous plasma MBG measurements. In WT-MBG and ADMBG mice, MBG was elevated. Although MBG did not have a direct effect on behavioral outcomes in WT or AD mice, studies indicate that MBG can raise CR in WT and AD mice. The number of trials in ADMBG vs. ADC were decreasing in the number of trials in ADMBG vs. ADC by a significant margin. MBG has a potential protective role against AD mice's cognitive impairment. The number of trials increased in the number of trials, and MBG may have reduced procedural learning capability in WT mice in WTM. In AD vs. WT, IL10 mRNA was 2fold lower and IL6 mRNA was the same as in Hippocampal's inflammatory marker IL10, which was 2fold lower, and the same in IL6 mRNA in ADC and VB are the same. Conclusions AD mice in comparison to WT mice developed early AD procedural learning impairment and CR disorder, which were accompanied by improved hippocampal AD markers that did not respond to inflammation marker activation, which were supplemented by elevated hippocampal AD markers without activation. MBG therapy may have a protective role against early-stage AD-related learning loss and CR disruption early-stage AD. MBG can have an effect on AD mice's different cognitive domains. Future studies will investigate the effects of MBG on the different cognitive domains.

Source link: https://onlinelibrary.wiley.com/doi/10.1096/fasebj.2022.36.S1.R2105


Brain dysmorphologies associated with Alzheimer disease in Down syndrome

On magnetic resonance images of the head, a series of 38 3D brain landmarks depicting the overall shape of the brain and internal brain structures. In people with AD, significant brain shape differences were found, mainly due to the shape of enlarged brain ventricles. Fortunately, people in advanced stages of the disease had more pronounced dysmorphologies than those in early stages and those with no signs of dementia, establishing a continuum in brain morphology that highlights the importance of this neurodegenerative disorder in brain morphology.

Source link: https://onlinelibrary.wiley.com/doi/10.1096/fasebj.2022.36.S1.R2435


Role of ACAT1 in Atherosclerosis and Alzheimer's Disease

The ACAT1 protein and its ACAT2 sibling help to catalyze the storage of cholesteryl esters. In function and structure, ACAT2 differs from ACAT1 in function and structure. ACAT2 has two domains and is primarily present in intestinal cells, and it controls lipoprotein particle secretion. The production of atheroma foam cells, cells characterized by the aggregation of these fatty plaque deposits on the walls of arteries, therefore appearing as foam, is key to the production of atheroma foam cells. During periods of cholesterol overload in the ER, ACAT1 maintains homeostasis. A pathogenic link has been identified between cholesterol and Alzheimer's disease or other neurodegenerative diseases in recent research. ACAT's specific drug therapy against atherosclerosis is currently being investigated by researchers. ACAT inhibition has been shown to be ineffective by latest research, but there are already potential immunotherapies for neurodegenerative disorders by the ACAT enzyme. The association of neurodegenerative disorders and the ACAT1 protein is yet to be determined by more research to be able to determine the association between neurodegenerative disorders and the ACAT1 protein.

Source link: https://onlinelibrary.wiley.com/doi/10.1096/fasebj.2022.36.S1.R4631

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions