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Alzheimer's disease is a progressive and fatal neurodegenerative disease that is one of the most common causes of dementia in the United States. Numerous literature findings indicate that Alzheimer's disease causes are not limited to the neural region alone, but that it also involves multiple immunologic pathways. Neuroinflammation has been described as a key step in AD pathology. inflammatory proteins have been shown by mounting evidence that disease progression could be attributed to an increase in inflammation. The present report summarizes the role of several inflammatory molecules and their potential use in dementia detection and monitoring.
Source link: https://doi.org/10.2174/1567205018666211202143935
Background: Neuroimaging studies shows that white matter microstructure is highly affected by Alzheimer's disease progression. However, whether changes in white matter microstructure are limited to particular areas and whether they can be used as potential biomarkers to distinguish normal control from AD is unknown. Methods: 33 cases of AD and 25 cases of NC were recruited for automatic fiber quantification in this cross-sectional study. Conclusions: In AD patients compared to healthy controls, there was a significant rise in the MD values. The major differences were concentrated in the left cingulum hippocampus, left uncinate fasciculus, and superior longitudinal fasciculus. These findings contribute to the understanding of AD's pathogenesis, and they show that abnormal white matter based on DTI-based AFQ results is able to determine AD's pathogenesis.
Source link: https://doi.org/10.2174/1567205019666220718142130
Background: Alzheimer's disease is the most common form of dementia in the elderly population, and it places a lot of emphasis on medical care and nursing. MBI was identified as a disorder with psychological and behavioral impairment before the onset of typical dementia-related cognitive symptoms in dementia in 2012, Alzheimer's Association International Conference, MBI, Alzheimer's Association International Conference, MBI was described as a disorder with psychiatric and behavioral disturbances long before the onset of common clinical cognitive impairments. MBI has been associated with early AD pathologies, including Au03b2 and tau, according to increasing lines of evidence. In the early detection of AD dementia, this narrative review intends to establish the advantages of MBI over another model of psychiatric and behavioral signs associated with AD. MBI may be a warning sign of AD's early pathology, and more attention should be paid to the number and duration of MBI symptoms. MBI may be a early warning and predictor of Alzheimer's disease dementia. Early intervention for MBI may have a positive effect on halting long-term cognitive decline.
Source link: https://doi.org/10.2174/1567205019666220805114528
RyRs are macromolecular complexes in which the protein-protein interactions between RyRs and several regulatory proteins influence channel function. In this article, we discuss our latest results, which revealed that posttranslational changes resulting in increased neuronal Ca2+ leak in AD is related to RyR2-mediated scaffolding and dissociation of the stabilizing protein Calstabin2 from the channel. In AD, we describe the RyR macromolecular complex structure and explore the underlying neural RyR2-26 remodeling process. As a new therapeutic window to treat/or prevent AD setting and/or progression, Targeting RyR macromolecular complex remodeling should be considered.
Source link: https://doi.org/10.2174/1567205017666200225102941
The aim of the research was to determine the effects of exercise on Alzheimer's disease's mitotic index by using the correct measurement methods.
Source link: https://doi.org/10.46309/biodicon.2022.1167227
Background: Early-onset Semantic dementia and early-onset Alzheimer's disease are often difficult to diagnose in the early stages of the disease because of the similarities of medical signs such as language disorders. Using the voxel-based specific regional analysis software for Alzheimer's disease, we compared the degree of atrophy in medial temporal tissue between the two types of dementia. The mean Z score in bilateral medial temporal structures was used to distinguish patients with EOSD and EOAD, as well as the absolute value of Z-score indicating the degree of asymmetrical atrophy in medial temporal structures. EOSD had significantly higher Z and laterality scores than the EOAD group, which was also higher than the EOAD group.
Source link: https://doi.org/10.2174/1567205019666220820145429
Background: Early-onset Alzheimer's disease is most common in women aged 60 to 65 years and accounts for 51% of all Alzheimer's disease cases. The variant Alzheimer's disease with spastic paraparesis has been characterized as a rare clinical condition characterized by early-onset dementia, spasticity of the lower limbs, and gait disorder. Although the disease was first identified with mutations in exon 9 of the PSEN1 gene, it was later discovered that variations in other exons were also responsible for the disease. In addition, we wanted to determine the distribution of mutations in varAD patients identified to date. In a family with two affected individuals who have varAD, we discovered a heterozygous splicing variant of the PSEN1 gene. Conclusion: We present the complete medical and genetic profiles of a Turkish patient with the diagnosis of varAD in the case with comparisons from the literature.
Source link: https://doi.org/10.2174/1567205019666220414101251
Background: Mild cognitive impairment and Alzheimer's disease are tested to see if the cognitive decline in older adults is due to psychiatric causes rather than normal aging. Objective: The aim of this study was to determine the diagnostic results of the Alzheimer's Disease Assessment Scale-Cognitive Subscale in MCI and AD screening for MCI and AD. The sROC AUC was 0. 97 percent, with 1,517 AD patients from ten studies finding the pooled sensitivity and pooled specificity were 0. 91 and 0. 93, respectively. Conclusion: The ADAS-Cog is a screening system that helps with MCI and AD diagnosis, as well as improved diagnostic results in patients with AD. ADAS-Cog is a first-stage screening device that can be used right away when early screening for AD is required.
Source link: https://doi.org/10.2174/1567205019666220404104854
However, probiotics' effect on AD needs to be more defined in preclinical and clinical studies. According to the Synthesis Without Metaanalysis Guideline, the findings were presented as a narrative synthesis. Because of rapid advancements in cognitive tests, the results showed significant differences in AD experimental models treated with probiotics alone or in combination. Probiotic supplementation seems to improve cognitive tests and raise the number of substances capable of delaying the neurodegenerative process of AD in experimental models.
Source link: https://doi.org/10.2174/1567205019666220318092003
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