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Alzheimer's Disease - BioProject

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Last Updated: 14 April 2022

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Fecal microbiota transplantation derived from Alzheimer's disease mice worsens brain trauma outcomes in young C57BL/6 mice

Traumatic brain injury can cause neuroinflammation and neurodegeneration, which can raise the risk of Alzheimer disease and accelerate Alzheimer disease progression. This research was conducted to see if AD mice's gut microbiota exacerbates neurological deficits after TBI in young control mice. We've developed fecal microbiota transplants from 18 to 24 months old mice and healthy controls. Full length 16S RNA sequence analysis of mice fecal samples Then, we characterized the microbiota composition of the mice fecal samples by full length.

Source link: https://www.ncbi.nlm.nih.gov/bioproject/826428


The impact of probiotic supplementation on cognitive, pathological and metabolic markers in a transgenic mouse model of Alzheimer’s disease

Aberrant metabolism can exacerbate brain degenerative disorders such as Alzheimer's disease and Alzheimer's disease. In this review, we examine the effect of the Lab4b probiotic consortium on i cognitive and pathological measures of AD development and ii metabolic stability in 3xTg-AD mice exposed to metabolic challenge with a high fat diet in 3xTg-AD mice. Compared to the control group 3xTg-AD+HFD+Lab4b, there was less change in novel object recognition and hippocampal neuronal spine density over the course of the study. The findings demonstrate the effectiveness of the Lab4b probiotic as a neuroprotective agent and encourage further studies with human participants.

Source link: https://www.ncbi.nlm.nih.gov/bioproject/822274


Gut microbiome alterations in Alzheimer’s disease

Although recent studies in rodents indicate that changes in the gut microbiome may lead to amyloid deposition, amyloid deposition, but AD-associated microbial communities have not been identified in humans. AD participants' gut microbiome has decreased microbial diversity and is stylistically different from control age- and sex-matched individuals, according to our results. In addition, we found correlations between the abundance of differentially abundant species and AD cerebrospinal fluid biomarkers. These results add AD to the growing list of diseases linked to gut microbial transformations, as well as suggesting that gut bacterial communities may be a point for therapeutic intervention.

Source link: https://www.ncbi.nlm.nih.gov/bioproject/821821


Microglial Piezo1 senses Aβ fibrils stiffness to restrict Alzheimer’s disease

Alzheimer's disease is linked to the onset of extracellular amyloid plaque, affecting brain tissue's mechanical properties. Cx3cr1CreER-EYFP; Piezo1fl/fl mice were crossed with Cx3cr1Creer-EYFP; Piezo1fl/fl mice; 5FAD; Piezo1fl/fl mice; 5FAD; Piezo1fl/fl mice; 5FAD; Piezo1fl/fl mice; 5:FAD; Piezo; 5; 5FAD mice were crossed with Cx3Creer-EYFP; Piezo3cr1Creer-EYFP; Piezo1Creer-EYFP; 5FAD; 5FAD mice; 5FAD; 5x3cr1Fl/Fl; 5FAD; 5FAD mice were 5FAD; 5FAD FAD and Piezo1fl/fl; FAD and Piezo1fl/fl; 5FAD mice and the control littermate mice died within 5FAD mice and the control littermate mice; FAD and Piezo1fl/fl; FAD and Piezo1fl/fl; FAD; Piezo1fl/fl; FAD; 5FAD mice; Piezo1; Piezo1fl; Piezo1fl/fl; Piezo1fl; Piezo1fl/fl; 5FAD mice; 5FAD littermate mice; Piezo; 51fl; FAD; 5; FAM; FAD; Piezo1fl; Piezo1fl/fl; Piezo1fl; 4; FAD; Piezo1; FAD; Piezo1fl; RNA was extracted from the indicated groups of RNA profiles for RNA profiling.

Source link: https://www.ncbi.nlm.nih.gov/bioproject/818969


Non-Transgenic Guinea Pig Strains Exhibit Hallmarks of Human Brain Aging and Alzheimer’s Disease

For most chronic diseases, including Alzheimer's disease, older age is the key risk factor. These new preclinical models to investigate brain aging and AD are mainly transgenic and harbor mutations that are intended to mimic brain pathologies associated with human brain aging/AD. Brain aging in PET GP is transcriptomically similar to human brain aging, according to our findings, although older DH brains are transcriptomically more similar to human AD. Both strains/models also have an elevated neurofilament light chain with age, and DH animals have higher S100 calcium-binding protein B, ionized calcium-binding adapter molecule 1, and A and phosphorylated tau, which are all typical signs of neuroinflammation-associated AD. Our findings show that both the PET and DH GP may be useful, non-transgenic models to investigate brain aging and AD. PolyA RNA-seq on cortex isolated from Pigmented and Hartley Guinea Pigs at 5 and 15 months of age.

Source link: https://www.ncbi.nlm.nih.gov/bioproject/816714

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions