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Metastatic breast cancer patients with minimal toxicities may live years with their disease on drugs with minimal toxicities for years, but they will eventually progress on first-line therapy. In estrogen receptoru2013positive, her2-negative disease, PIK3CA mutation testing is recommended for those eligible for second-line therapy. Hyperglycemia is a common side effect of alpharemia. We discuss a case of diabetic ketoacidosis necessitating intervention in the intensive care unit of a woman with type 2 diabetes mellitus who started on alisib. Since progress on first-line therapy, a 76-year-old female with diet-controlled T2DM and mBC was put on second-line therapy with alchib. We have five recommendations to avoid hyperglycemia in those on apelisib: stringent guidelines for starting alglycemia, comprehend the steps required to prevent hyperglycemia, aid a multidisciplinary team, take action immediately if hyperglycemia is identified, and log blood glucose levels.
Source link: https://doi.org/10.1177/23247096221105249
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