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Several studies have shown that serum uric acid levels in diabetic patients are higher than those in healthy people, and that in diabetic patients, is linked to acute albuminuria and elevated serum creatinine. Methods We thoroughly searched five electronic resource databases for randomized controlled trials that compared the efficacy and safety of allopurinol versus placebo in the treatment of diabetic patients with diabetes mellitus. Compared to conventional therapy or placebo, Allopurinol was more efficient in lowering serum uric acid levels in comparison to placebo or placebo. The Scr of patients with an allopurinol treatment duration of fewer than six months was significantly shorter than that of the control group, according to a subgroup analysis of Scr. To clarify the role of allopurinol use in lowering blood pressure, monitoring blood glucose levels, and improving renal function in diabetic patients, diabetic patients with diabetes, more RCTs with larger sample sizes and higher quality are required.
Source link: https://europepmc.org/article/MED/35856157
Hence, the present research sought to investigate the histological and neurobehavioral effects of Allopurinol in older rats that received repeated TBI. Rats sustained 5 repeat TBI/sham injuries 24 hours apart and were treated with saline or Allopurinol 100 mg/kg, i. p. On day 6, half of the animals from each group were killed, and the remaining animals were evaluated with Open field, Elevated plus maze, and Morris Water Maze. Every other day until the 19th day from the last accident, basic neurological tests were performed with neurological assessment equipment. In rats receiving saline versus those receiving allopurinol therapy, the number of neurons was markedly reduced in CA1, GD, and PC. The brain tissues were reduced after allopurinol administration at 6 and 19 days post-injury, according to immunohistochemical results.
Source link: https://europepmc.org/article/MED/35931122
After 28 days of therapy, we investigated the possibility of pharmacotherapy to reduce clinical signs of disease, antibody levels, and skin parasite load using indirect fluorescence antibody test and skin parasite load by qPCR. In all three treatment groups, we found a moderate correlation between the skin parasite load and the clinical score. Antibody levels did not decline in this short period. In the short run, it was determined that allopurinol reduced the number of parasites in dogs with visceral leishmaniasis in the skin.
Source link: https://europepmc.org/article/MED/35920471
In the latest report, we analyzed the Vietnamese spontaneous reporting database to find signs and preventability of allopurinol-induced SJS/TEN in Vietnam from 2010 to 2019. Among the 72,822 spontaneous ADR reports submitted to the Vietnam National Drug Information and Adverse Drug Reaction Monitoring Centre, 392 reported were on SJS/TEN, of which 65 cases were related to allopurinol. Unapproved indications, too high initial dose, and even rechallenging in patients with a history of allopurinol allergy were allopurinol allergy. 66% of the SJS/TEN cases were avoidable because they were linked to inappropriate prescribing such as unapproved drugs, improper dose, too high initial dose, and even arresting in patients with a history of allopurinol allergy. According to our first study, which specifically focusing on allopurinol's ADR avoidability, can result in the avoidance of more than 60% of SJS/TEN cases in Vietnamese allopurinol users.
Source link: https://europepmc.org/article/MED/35848069
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