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Allergic Rhinitis - Europe PMC

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Last Updated: 04 August 2022

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Tanshinone IIA alleviates ovalbumin-induced allergic rhinitis symptoms by inhibiting Th2 cytokine production and mast cell histamine release in mice.

Context Studies have shown that tanshinone IIA has an anti-inflammatory effect, but the effect on allergic rhinitis is uncertain. TIIA or dexamethasone was used by AR mice in the dose control groups, according to the dose testing groups. Human mast cells were treated with C48/80 to produce histamine or TIIA for therapeutic use, and the cell viability, histamine content, and mast cell degranulation were investigated. Results In serum or NALF of OVA-induced AR mice, OVA-IgE, OVA-IgG1, TNF-u03b1, IL-4, and IL-5 were shown in OVA-induced AR mice, boosting the number of nasal rubbings in mice, increased the number of nasal mucosal tissue, and dramatically elevated the levels of histamine, OVA-IgE, OVA-IgG1, IL-4, However, both TIIA and Dex delayed the effects of OVA on AR mice. TIIA helps with OVA-induced AR symptoms in AR mice, and it could be used as a therapeutic drug for patients with Th2-, or mast cell-allergic disorders.

Source link: https://europepmc.org/article/MED/35167426


Study on the mechanism of allergic rhinitis based on the expression of FIB, PCT, hs-CRP, and Th17/Treg-IL10/IL-17 axis balance

Method: 48 female SPF SD rats were randomly divided into three groups, including a blank control group, an AR group, and an IL-10 intervention group. The rats in the control group were treated with normal saline; in the AR group, they were given 20 u03bc L of saline containing 50 g of OVA every day. The rats in the IL-10 intervention group were intraperitoneally injected with 1 mL of 40 pg/kg IL-10 and then provided with OVA. By flow cytometry, the presence of Treg and Th17 cells in serum was determined. Results: The AR group's snots, nasal itching, and sneezing scores were all significantly higher than those in the control group, although the IL-10 intervention group's scores were lower than those in the AR group. In the nasal mucosa in the AR group, the levels of FIB, PCT, hs-CRP, IgE, and OVAs IgE were higher than those in the blank control group. In the nasal mucosa in the IL-10 group, the amounts of FIB, PCT, hs-CRP, IgE, and OVAs IgE were lower than those in the AR group, although TIM and IL-17 proteins were lower than those in the AR group. IL-10 can cause allergies in AR rats by altering the expression of FIB, PCT, and hs-CRP, as well as the balance of the Th17/Treg-IL-17 axis in the nasal mucosa.

Source link: https://europepmc.org/article/PPR/PPR526541


Allergic Rhinitis Seasonality, Severity, and Disease Control Influence Anxiety and Depression.

Objectives: Allergic rhinitis has been attributed to anxiety and depression. The AR symptoms's frequency and intensity have remained variable. Hospital Anxiety and Depression Scale, Beck Anxiety Inventory, and Beck Depression Inventory-II identifies anxiety and depression. Any of the measured anxiety or depression scores was related to the occurrence, degree of control, seasonality, or severity of AR in a linear regression study. We designed linear regression models evaluating the relationship between any of the evaluated anxiety or depression scores and the occurrence, source of control, seasonality, or severity of AR. Study We analyzed 115 participants with AR and 38 with no respiratory signs, as well as 38 people with no respiratory problems. Patients with AR experiences higher anxiety and depression scores. A moderate/severe presentation of AR was also associated with higher scores of anxiety and depression. Conclusions: The presence of AR, a poorer source of oversight, and a moderate/severe representation of the condition were both strongly associated with elevated scores of anxiety and depression.

Source link: https://europepmc.org/article/MED/35912902


Anxiety in Adults with Allergic Rhinitis During the Coronavirus Disease 2019 Pandemic: A Canadian Perspective.

Despite the symptom similarity between allergic rhinitis and Coronavirus Disease 2019, pandemic-time anxiety in people with AR is still a topic of limited research. The COVID-19 Associated Anxiety in patients with Asthma and AR Experiencing Symptoms survey was released on the "Qualtrics XM" website, with 835 adult participants responding to the first iteration, from April-August 2020. High rates of anxiety were found, with 28. 0% of the AR group and 27. 5% of the control group meeting diagnostic criteria for generalized anxiety disorder. For the total RQLQ score and all 7 domain scores, there were significant positive correlations between anxiety and disease for the total RQLQ score and all 7 domain rankings, with the non-nose/eye symptom domain having the greatest correlation. Regardless of AR status, high levels of anxiety persist in the COVID-19 pandemic, underscoring the importance of early anxiety testing in all patients.

Source link: https://europepmc.org/article/MED/35918024


Anxiety in Adults with Allergic Rhinitis During the Coronavirus Disease 2019 Pandemic: A Canadian Perspective

Despite the fact that allergic rhinitis and Coronavirus Disease 2019 overlap, pandemic-time anxiety in people with AR remains a topic of limited research. Methods COVID 19 Associated Anxiety in Patients With Asthma and AR Experiencing Symptoms survey was published on the u201cQualtrics XM203d website, with 835 adult participants responding to the first iteration, April-August 2020. Conclusions The research group's high rate of anxiety was found, with 28. 0% of the AR group and 27. 5% of the control group meeting diagnostic criteria for generalized anxiety disorder. For the total RQLQ score and all 7 domain scores, there were strong positive correlations between anxiety and burden of disease, with the non-nose/eye symptom domain having the highest correlation. Conclusions Despite AR status, high levels of anxiety persist during the COVID-19 pandemic, undermining the importance of early anxiety testing in all patients.

Source link: https://europepmc.org/article/MED/PMC9338449


An anti-inflammatory and anti-fibrotic proprietary Chinese medicine nasal spray designated as Allergic Rhinitis Nose Drops (ARND) with potential to prevent SARS-CoV-2 coronavirus infection by targeting RBD (Delta)- angiotensin converting enzyme 2 (ACE2) binding.

Background Since the outbreak of COVID-19 has resulted in over 313,000,000 reported cases of infection and over 5,500,000 deaths, over 5,500,000 deaths, extensive research has been carried out to find agents/ vaccines against COVID-19. An increasing number of citations based on clinical trials of traditional Chinese drugs in the treatment of COVID-19 have been published. The results indicated that ARND not only reduced pseudovirus infection and undermined the Spike protein's binding affinity, but also attenuated the inflammatory response after infection, resulting in a healthier prognosis with a reduced risk of pulmonary fibrosis. In vivo and COVID-19 patients, the results in this review also provide a basis for further research into ARND as an antiviral hygienic drug and further studies on ARND as an antiviral hygienic drug. Conclusion ARND may be used as a safe anti-SARS-CoV-2 agent with the ability to reduce SARS-CoV-2 coronavirus infection.

Source link: https://europepmc.org/article/MED/35897044


Update on pathomechanisms and treatments in allergic rhinitis.

Allergic rhinitis is a global health issue of increasing incidence, in conjunction with an elevated socioeconomic and socioeconomic burden, leading to an increasing prevalence. In this review article, the recognition of immune cells including type 2 innate lymphocytes, T helper T cells, follicular regulatory T cells, follicular regulatory T cells, B cells, dendritic cells, and epithelial cells in AR pathogenesis has been expanded.

Source link: https://europepmc.org/article/MED/35892225


Peripheral Circular RNA Profiling from Patients with Allergic Rhinitis Identified hsa_circRNA_404013 as a Potential Diagnostic Biomarker.

Introduction To date, the investigation of peripheral circular RNA expression profiles in patients with allergic rhinitis was non-existent, and we wanted to determine the circRNA expression profile and select the candidate biomarker from AR. In the peripheral blood sample from AR patients and healthy controls, the Methods circRNA chip was used to screen differently expressed circRNAs. 79 AR patients and 48 healthy controls were significantly raised in AR's cirRNA chip and further determined in 79 AR patients and 48 healthy controls. The area under curve of 0. 8499 was found that hsa_circRNA_404013 could be used as a peripheral blood circulating marker for the diagnosis of AR. Conclusions The expression profile of circRNAs from a peripheral blood sample of AR patients was determined.

Source link: https://europepmc.org/article/MED/35882184


Mometasone Furoate in Non-Allergic Rhinitis: A Real-Life Italian Study.

Background In order to determine the safety of intranasal mometasone furoate in patients with non-allergic rhinitis, a real-life, observational, prospective study is conducted. Conclusions Intranasal mometasone furoate is a safe treatment for patients with NAR.

Source link: https://europepmc.org/article/MED/35887676


Prevalence of allergen sensitization among 1248 children with allergic rhinitis in Changzhou, China

In Changzhou, eastern China, goal: To establish the sensitivity of children with allergic rhinitis and common inhaled and food allergens among children with allergic rhinitis and provide a basis for clinical evaluation of pediatric allergic status and prevention strategies for allergen avoidance. Methods: A total of 1248 children with AR were enrolled at the Third People's Hospital in Changzhou between January 2018 and December 2019. Using the AllergyScreen test, serum-specific immunoglobulin E to 19 types of inhaled and food allergens, as well as serum total IgE were detected. The positivity rate of inhaled allergens was 80. 5 percent, while the positivity rate of food allergens was 66. 19%. With an increase in age, the inhaled allergen positivity rate soared, while the food allergen positivity rate decreased. Result: dermatophagoides pteronyssinus was the most common sensitizing allergen in pediatric patients with AR in Changzhou.

Source link: https://europepmc.org/article/PPR/PPR520589

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions