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Allergic Conjunctivitis - Springer Nature

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Last Updated: 28 July 2022

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Reproxalap Activity and Estimation of Clinically Relevant Thresholds for Ocular Itching and Redness in a Randomized Allergic Conjunctivitis Field Trial

In an allergic congenital trial, this clinical trial investigated the use of reproxalap, a novel reactive aldehyde species modulator, and estimated clinically relevant thresholds for changes in ocular itching and redness. Patients with ragweed-associated allergic conjunctivitis were evaluated for over 28 days in an environmental environment with approximately four doses per day of either 0. 2 percent reproxalap, 0. 5% reproxalap, or vehicle. The meaningful within-patient change and the between-group meaningful difference for patient-reported ocular itching and redness was estimated to be about 0. 5 percent using three anchor-based and three distribution-based methods. The first such estimates for the standard ocular itching and redness scores of 0. 5 units are among the first such estimates for allergic convulsion tests, providing valuable context for the clinical interpretation of clinical trials in allergic conjunctivitis. Though allergic convulsions affect millions of patients around the world, new approaches have not been introduced in decades. Patients with ragweed-associated allergic conjunctivitis were monitored for over 28 days and were provided one of three potential eye drops at around four doses per day; 0. 25 reproxalap; 0. 55 reproxalap; or car, which was made of the same ingredients but did not contain reproxalap. When pollen counts were high on days when pollen counts were high, reproxalap was significantly higher than vehicle in lowering itching and tearing scores, and was more effective than vehicle in lowering redness and eyelid swelling scores. After eye drop administration, the most common side effect was transient ocular discomfort.

Source link: https://doi.org/10.1007/s40123-022-00520-z


Impaired sleep quality in children with allergic conjunctivitis and their parents

Objectives: To determine the sleep quality in children with allergic conjunctivitis and their parents, it should be investigated. Using the Children's Sleep Habits Questionnaire and Pittsburgh Sleep Quality Index, the children and parents were evaluated.

Source link: https://doi.org/10.1038/s41433-022-02182-4

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions