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Allergic Conjunctivitis - PubMed

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Last Updated: 28 August 2022

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Emerging therapies targeting eosinophil-mediated inflammation in chronic allergic conjunctivitis.

Eosinophils are key to the pathophysiology and sustaining the immune response present in ocular allergy disorders that include vernal keratoconjunctivitis and atopic keratoconjunctivitis. These emerging therapies, based on preclinical and clinical results from both ocular and non-ocular allergy research, indicate that further research into lowering the risk of disease in patients with persistent ocular allergy should be done.

Source link: https://doi.org/10.1016/j.jtos.2022.08.004


Conjunctival Intraepithelial Lymphocytes, Lacrimal Cytokines and Ocular Commensal Microbiota: Analysis of the Three Main Players in Allergic Conjunctivitis.

The cellular and microbial populations of the conjunctiva and the lacrimal soluble molecules of the conjunctiva and the lacrimal soluble molecules were investigated for the key biomarkers of allergic conjunctivitis for the purpose of this research. A total of 35 healthy individuals, 28 patients with seasonal allergic conjunctivitis, and 32 people with chronic allergic conjunctivitis were all recruited to obtain peripheral blood, conjunctival brush cytology, tear fluid, and microbiota samples. An elevated number of Th2 and NKT lymphocytes was discovered for perennial allergic conjunctivitis, as well as double negative MAIT cells, but TCRu03b3+ lymphocytes and double negative MAIT cells were reduced. In contrast, an increase in Th17 and Th22 cell counts was distinguishable, but the Th1 cell number decreased. The vast majority of pro-inflammatory cytokines in perennial allergies and MMP-9, as well as IgA in seasonal allergies, were raised among tear fluid.

Source link: https://doi.org/10.3389/fimmu.2022.911022


Effects of Antihistamine-Releasing Contact Lenses on Severe Allergic Conjunctivitis.

Even with ocular-allergic signs and findings, half of the patients who used CL regularly did not want to switch to spectacles. As a result, continued CL use with suppressed ocular allergy can raise efficiency and quality of life for CL users. This review details the clinical routes of CL users with ocular-allergic conjunctivitis who started ARCL trials on their eyes. ARCL can be a useful tool for CL patients with allergic convulsions. However, ARCL should be used after allergic conctivitis is controlled or becomes symptomatic.

Source link: https://doi.org/10.1080/09273948.2022.2103001


Characteristics of histamine H4 receptor agonist-induced allergic conjunctivitis model in Guinea pigs.

As a new therapeutic drug candidate, the most recent cloned histamine H4 receptor antagonist is highly awaited. The H4 receptor's affinity for histamine varies among species, and it is known that the guinea pig H4 receptor's histamine binding affinity is closer to that for human receptor than mouse receptor. We investigated the possibility that a guinea pig model could be used as a drug effectiveness evaluation tool with higher evaluation fidelity than the mouse model in this article. Though allergic conjunctivitis do not appear in the guinea pig model, the findings of this research indicate that this model may be used as a simple screening device in the early stages of drug discovery.

Source link: https://doi.org/10.1016/j.vascn.2022.107203

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions