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Using ambient pollen exposure in the Milan area during the 2014 ragweed season, we determine the pollen/symptom thresholds and determine the effectiveness of ragweed allergen immunotherapy. Autoregressive distributed lag models were used to create predictive models of daily symptoms and analyze the short-term effects of pollen concentration changes on symptoms onset. In both AIT treated and in AIT treated patients, we found strong correlations between ragweed pollen load and the severity of symptoms for all three symptom categories. In no AIT treated patients than in AIT treated patients for both symptom categories, mean symptom levels were significantly higher in all symptom groups. The Ragweed pollen concentration can be used to predict symptom severity in patients with a ragweed allergy.
Source link: https://europepmc.org/article/MED/36151263
Allergic conjunctivitis is an immune-mediated inflammatory disease of the conjunctiva that is induced by antigens. Allergic congenitis can cause a variety of signs, including ocular itching, hyperemia, and edema. For diagnosing allergic conjunctivitis, developing experimental animal models that show clinical signs and methods for quantitative and objective evaluation is important. Consequently, this research was intended to develop an ovalbumin-induced mouse model of allergic conjunctivitis and a useful tool for determining allergic conjunctivitis symptoms. On days 0 and 5, ICR mice were wokened by an intraperitoneal injection of OVA in PBS containing alum. Group 1, 0. 1% betamethasone; Group 2, 0. 02 percent lemabastine; and Group 3 PBS. Mice exhibited eye scratching behaviour, hyperemia, edema, ema infiltration of eosinophils into tears, as well as elevated antigen-specific immunoglobulin E antibodies in tears and serum.
Source link: https://europepmc.org/article/MED/36130665
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