* If you want to update the article please login/register
The cellular and microbial populations of the conjunctiva and the lacrimal soluble molecules were investigated for the key biomarkers of allergic conjunctivitis, according to the purpose of this review. Thirty healthy people, 28 subjects with seasonal allergic conjunctivitis, and 32 people with chronic allergic conjunctivitis were recruited to obtain peripheral blood, conjunctival cytology, tear fluid, and microbiota samples. An increased number of Th2 and NKT lymphocytes was found for chronic allergic conjunctivitis, as well as double negative MAIT cells, which were reduced. An increase in Th17 and Th22 cell numbers in comparison to seasonal allergic convulsion, however, Th1 cell proportions decreased in comparison, while Th17 and Th22 cell numbers increased. The vast majority of pro-inflammatory cytokines in perennial allergies and MMP-9, as well as IgA in seasonal allergies, was elevated among tear fluids.
Source link: https://doi.org/10.3389/fimmu.2022.911022
In the qualitative analysis, five articles describing AC incidence among individuals with DE and six articles reporting DE incidence among people with AC were included in the qualitative analysis. The DE outbreak among people with AC was 0. 9 percent among those with AC; the AC incidence among people with DE was 6. 2 percent, or 38. 0%. According to each issue, 47. 2% of patients with AC had comorbid DE and 17. 8% of patients with DE had comorbid AC, according to a random-effects study. In highly vulnerable populations, comprehensive screening and treatment for patients with DE and AC can improve long-term outcomes and reduce chronic ocular damage.
Source link: https://doi.org/10.3390/jcm11133643
Objective: To determine the effectiveness of anti-allergic eye drops, we need to determine ocular surface temperature. Threeteen asymptomatic patients with suspected seasonal allergy conjunctivitis due to cedar pollen were studied. To cause the allergic reaction, a drop of cedar pollen solution was added to the conjunctive sac. With a newly developed non-contact ocular surface thermographer, the inferior bulbar conjunctiva's surface temperature was measured before and 30 min after the CAC. Results: The temperature in the artificial tear eyes increased by 0. 67 u00b0C>u00b1 0. 10 u00b0C in the artificial tear eyes, but not by 0. 16 u00b1 0. 06 u00b0C in the levocabastine eyes following the CAC, but not by 0. 06 u00b0C in the levocabastine eyes. Conclusion: The significant correlation of the conjunctival surface temperature with the severity of the conjunctival allergic reaction indicates that the temperature measured by the OST can be used to objectively determine the efficacy of topical anti-allergic agents.
Source link: https://doi.org/10.1159/000357105
Purpose: By using a mouse allergic conjunctivitis model, we were able to determine the inhibitory effects of dexamethasone and heparin on the infiltration of mast cells in the conjunctiva. The mice in group 2 were treated with topical 0. 1% dexamethasone eye ointment, and the mice in group 3 were treated topically with 5,000 IU/ml heparin. Instead of dexamethasone or heparin, Hanks' balanced salt solution was added to both eyes of the mice in group 4 rather than dexamethasone or heparin. Result: Mast cells, infiltrating the subconctival tissue, were significantly lower in group 2, group 3, and group 4 when compared to group 1, which was much smaller than group 1. Conclusions: Topical heparin may be a viable option in treating IgE-induced allergic eye disease in experimental acute allergic eye disease treated with topical dexamethasone.
Source link: https://doi.org/10.1159/000350551
Objective: To evaluate the efficacy of a combined therapy with levocabastine hydrochloride ophthalmic suspension and pemirolast potassium ophthalmic solution in comparison to single therapy with levocabastine hydrochloride ophthalmic suspension alone. Methods: Thirty-two allergic conjunctivitis patients were randomly assigned to either-treatment or single-treatment groups. Conclusions: Both objective and subjective signs of allergic congenitis showed the greatest improvements when patients were treated with combined therapy as opposed to single-agent therapy.
Source link: https://doi.org/10.1159/000130072
Objectives: Our aim was to determine factors associated with IL13 polymorphism and other environmental comorbidities such as subject-reported allergic rhinitis and/or allergic conjunctivitis symptoms in adult asthmatics. Methods: In a questionnaire, a population-based study of Finnish adult asthma patients and matched controls was mixed in a questionnaire. Asthma was diagnosed based on a typical history of asthma attacks and lung function tests. For a subsample, Skin prick tests with 17 aeroallergens and blood tests, as well as analysis of interleukin 13 rs20541 genotypes, were carried out. The proportion of asthmatics reporting AR was 69%, while reporting AC was 40. 7%.
Source link: https://doi.org/10.1159/000456009
* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions