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Allergen - Wiley Online Library

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Last Updated: 28 September 2022

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Allergen‐specific immunotherapy induces monocyte‐derived dendritic cells but attenuates their maturation and cytokine production in the lesional skin of an atopic dermatitis mouse model

We performed ASIT on this AD mouse model by dinitrofluorobenzene and an extract of Dermatophagoides farina, to determine the safety of ASIT and analyze its biological mechanisms. ASIT's findings revealed that we could not only reduce AD mice's skin lesions and scratching habits, but also inhibited their Th2u2010type immune responses. As immature and semi-u2010mature dendritic cells preferentially promote tolerance formation, storage, and storage, accumulation may be delayed, but monocyte-u2010derived dendritic cells' maturation after ASIT may point to a new mechanism of ASIT and a potential therapeutic target for AD.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/1346-8138.16582


Allergen recognition by specific effector Th2 cells enables IL‐2‐dependent activation of regulatory T‐cell responses in humans

We found that prolonged food allergen exposure in the form of oral immunotherapy resulted in an elevated risk of Tregs in patients with persistent clinical tolerance. We wanted to determine regulatory aspects of the CD4+ Tu2010cell response to food allergens by testing their functional activation in vitro and in vivo. Compared to the clonally enriched pathogenic effector Th2 cells, two subsets of Tregs expressing CD137 or CD25/OX40 were found with a delayed kinetics of activation. After the initiation of the allergen-specific Th2 response, In vivo exposure to peanut in the form of an oral food challenge of allergic patients resulted in a delayed and persistent activation of Tregs. The novel results of our research show that a sustained wave of Treg activation is triggered by the release of ILu20102 from Th2 effector cells, as well as the suggestion that therapeutic administration of ILu20102 could enhance current OIT approaches.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/all.15512


Real‐world evidence for the long‐term effect of allergen immunotherapy: Current status on database‐derived European studies

Since marketing approval showing how RCT findings are translated to real life care, real word and the resulting real-u2010world results are getting more important for determining drug effectiveness. Several RWE studies based on large prescription databases have been tested to determine the safety of allergen immunotherapy. AIT was more effective in preventing allergic rhinitis progression than compared to a non-u2010AIT control group receiving only symptomatic treatment for AR for up to six years. Adherence to AIT decreased during the suggested 3rd of the AIT protocol in the majority of studies, but more adherence to subcutaneous than to sublingual AIT was noted in most studies. The analysis of long-term effectiveness results of RWE studies based on prescription databases shows the long-term benefits of AIT demonstrated in RCTs, which can be found long-term.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/all.15506


Taro raphide‐associated proteins: Allergens and crystal growth

In bundles found in intravacuolar membrane chambers of most plant families, calcium oxalate raphide crystals are present in bundles. One of the five raphide profiling genes was highly expressed in the apex and had a 17–u2010amino acid insert that greatly raised that profilin's antigenic epitope value. Taro profilins exhibited 83% to 92% similarity to known characterized profilins, with 93% to 92% similarity to known characterized profilins. Profilein is a secondary allergen in hazelnuts, and commercial allergen test strips for hazelnuts are also available for screening in a taro germplasm to minimize acridity and food processing to avoid overcooking.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/pld3.443


Role of ventilation and cleaning for controlling house dust mite allergen infestation: A study on associations of house dust mite allergen concentrations with home environment and life styles in Tianjin area, China

We inspected 399 homes in Tianjin, China, to determine house dust mite allergen exposure in northeast China and determine its connection with indoor environmental causes and cleaning practices. High indoor air relative humidity, low air change rate, indoor dampness, and frequent changes of quilt cover/pillow case were all significantly linked to high house dust mite allergen concentrations, as shown by the following. A high ventilation reduces house dust mite allergen concentrations in indoors and outdoors due to an increased air change rate. The results of this report reveal the importance of ventilation and cleaning for battling house dust mite allergens. According to us, the decrease in additional absolute humidity with increased air change rate could be the most likely explanation for the low humidity in addition to increased air change rate, reducing household dust mite allergen concentrations.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/ina.13084


Effects of cold plasma on food poisoning microbes and food contaminants including toxins and allergens: A review

Cold plasma has emerged as a key component of non-u2010thermal processing of food. In the inactivation and inhibition of food poisoning microbes, CP plays a vital role. The study also emphasizes the impact of CP on other food contaminants, including pesticide and heavy metal toxicity.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/jfpp.17010

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions