AllerGen - OSTI GOV

Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement

Allergic reactions are triggered by the allergic crosslinking of allergen-specific immunoglobulin E bound to Fc-epsilon receptors on effector cells. In mice and cat-allergic patients, a single dose of blocking IgG reduces clinical signs in reaction to nasal allergy, and in cat allergy sufferers, with a magnitude seen on day 8 that was similar to that in years of conventional SIT.

Source link: https://www.osti.gov/biblio/1624085

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