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The Ambrosia artemisifolia is an anemophilous plant of the Asteraceae family that has possibly originated in desert areas of the United States. Although the plant prefers dry, sandy soils, climate change can play a significant role in its propagation in northern and central Europe, when the plant prefers dry, sandy soils. The pollen is considered highly allergenic, so it is likely that lower pollen concentrations are sufficient to cause allergy symptoms in comparison to native grass or birch pollen. Basically, threshold concentration could be determined by a target organ specific allergen challenge, field study, and allergen chamber challenge, each of which has its own benefits and drawbacks. To date, allergy challenge chambers have mostly been used for proof-of-concept studies with antiallergic agents. Eventually, a concentration range for ragweed and birch pollen can be determined that causes allergic symptoms with clinical and statistical significance.
Source link: https://clinicaltrials.gov/ct2/show/NCT05346718
Atopic dermatitis is a chronic skin disease characterized by a revolving course and a typical clinical manifestation of itchy, eczematous lesions. It was also shown in the 1920s that sleeping in an allergen-free chamber has a positive effect not only on asthmatic symptoms but also on AD patients' skin health. However, a new analysis indicated that challenge chamber exposure to airborne grass pollen allergens can lead to a clinical worsening of the skin disease in sensitized AD patients. The HDM allergen binds specific T cells in the skin and a proinflammatory signaling are associated with the proliferation of specific T cells in Langerhans cells as a result of specific IgE-Fc receptors. However, airborne HDM allergen exposure hasn't been shown to cause AD elevation in any controlled environment until now.
Source link: https://clinicaltrials.gov/ct2/show/NCT05019209
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