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Aliskiren - U.S. Department of Veterans Affairs

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Last Updated: 16 January 2022

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Aliskiren and valsartan mediate left ventricular remodeling post-myocardial infarction in mice through MMP-9 effects.

C57BL/6J wild type and MMP-9 void mice were divided into 4 groups at 3h post-MI: saline, valsartan, aliskiren, or a+v and compared to no MI manages at 28days post-MI. Saline treated WT mice showed raised end diastolic and systolic quantities and hypertrophy index, in addition to reduced ejection fraction. Aliskiren undermined the rise in end systolic quantity and hypertrophy index, while valsartan enhanced end diastolic volumes and aliskiren+valsartan enhanced the hypertrophy index just when MMP-9 was absent. This research study reveals that MMP-9 manages aliskiren and valsartan effects in mice.

Source link: https://doi.org/10.1016/j.yjmcc.2014.04.007

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions