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Albumin - OSTI GOV

Summarized by Plex Scholar
Last Updated: 09 January 2022

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177 Lu-Labeled Phosphoramidate-Based PSMA Inhibitors: The Effect of an Albumin Binder on Biodistribution and Therapeutic Efficacy in Prostate Tumor-Bearing Mice

Prostate-specific membrane antigen continues to be an active biomarker for small-molecule PSMA-targeted imaging and therapeutic agents for prostate cancer and different non-prostatic growths that are characterized by PSMA expression on their neovasculature. One of the difficulties for small-molecule PSMA preventions relative to delivering healing payloads is their quick renal clearance. The radiolabeling of CTT1401 and CTT1403 was accomplished utilizing click chemistry to link 177 Lu-DOTA-N3 to the dibenzocyclooctyne -bearing CTT1298 prevention cores. And while both compounds displayed excellent uptake and rapid internalization in PSMA+ PC3-PIP cells, the albumin binding moiety in CTT1403 provided clear advantages to the PSMA-inhibitor scaffold including enhanced flowing half-life and prostate tumor uptake that remained to enhance as much as 168 h post-injection. This after that boosted tumor uptake equated into remarkable restorative effectiveness of CTT1403 in PSMA+ PC3-PIP human xenograft tumors.

Source link: https://www.osti.gov/biblio/1393445

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions