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Air Pollution - ClinicalTrials.gov

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Last Updated: 08 May 2022

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Household Air Pollution and Health: A Multi-country LPG Intervention Trial

The resulting household air pollution caused by the 2010 global burden of disease, accounting for an estimated 4. 3 million deaths annually, many among women and young children. This study aims to conduct a random controlled trial of LPG stove and fuel distribution in 3,200 households in four LMICs to provide extensive evidence regarding health benefits throughout the lifespan. Each intervention center will randomly select half of their households to receive LPG stoves and an 18-month supply of LPG. When the child is 1 year old, the mother will be followed along with her child. The researchers will also enroll and follow her during the 18-month follow-up period in order to determine cardiopulmonary, metabolic, and cancer outcomes in households with a second, non-pregnant older adult woman. Behavior change tactics will be used by the researchers in order to optimize intervention use. This report will assess cookstove use, perform repeated personal exposure surveys to HAP, and gather dried blood spots and urine samples for biomarker analysis and biospecimen storage on all participants at various time points. This research will examine the following objectives: use an intent-to-treat analysis, determine the effect of a randomized LPG stove and fuel interventions on health in four diverse LMIC populations using a common protocol, determine the risks of exposure and health effects, and determine relationships between LPG intervention and both planned and exploratory biomarkers of exposure/health outcomes.

Source link: https://clinicaltrials.gov/ct2/show/NCT02944682


The Effects of Maternal Exposure to Air Pollution During Pregnancy on Adverse Pregnancy Outcomes Mediated by Inflammatory Cytokine and Hormone

The effect of air pollution on health has been particularly emphasized since the introduction of perspective in environment and health. In other ways, air pollution can alter maternal steroid hormone levels, which play a significant role in pregnancy maintenance and the development of adverse pregnancy outcomes. This is a prospective cohort study conducted by the First Affiliated Hospital of Xi'an Jiaotong University from January 2020 to December 2022, 288 pregnant women will be recruited from the First Affiliated Hospital of Xi'an Jiaotong University. According to resident information of participants, the motherhood exposure level of air pollutants in every trimester will be determined based on air pollution detection station in Shaanxi, according to resident data; three Serum indicators: fasting venous blood samples will be collected and tested in the laboratory of First Affiliated Hospital of Xi'an Jiaotong University. The samples will be tested according to -20 ° C, chemiluminescence and ELASA will be used to analyze the samples respectively, with the blood sample being placed in dry test tubes, centrifuged within an hour, and standardized serum will be used to analyze the samples respectively. The odds ration value and 95% confidence intervention of air pollution will be calculated for socioeconomic, diet, and other variables; 3Analysis of intermediary factors: maternal hormone and inflammatory cytokine mediate adverse pregnancy outcomes as a result of maternal air pollution exposure will be determined in the multivariate regression, as well as other variables; 4Analysis of adverse pregnancy outcomes will be used to determine the critical period of pregnancy outcomes under maternal exposure to air pollution exposure; and measurement of adverse pregnancy outcomes will be sensitivity of adverse pregnancy results will be determined for adverse pregnancy sensitivity will be adjusted for adverse pregnancy outcomes will be determined for adverse pregnancy results will be used to determine the adverse pregnancy outcomes will be used to determine the adverse pregnancy outcomes will be determined toxicity;.

Source link: https://clinicaltrials.gov/ct2/show/NCT04215406

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions