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Aerobic Exercise - U.S. Department of Veterans Affairs

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Last Updated: 24 January 2022

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Musclin, A Myokine Induced by Aerobic Exercise, Retards Muscle Atrophy During Cancer Cachexia in Mice.

We asked whether aerobic exercise leads to protein secretion by skeletal muscles of proteins that can be compared to cachexia. Amphiregulin, natriuretic peptide precursor B, musclin, and fibroblast growth factor 18 were discovered by microarray results as myokines were significantly influenced by PGC1. Just musclins were found to be lacking muscle mass in mice with a rare human renal carcinoma, and in atrophying myotubes, where PGC1 expression is impaired. We electroporated the Tibialis Anterior of C26-bearing mice with muscle or natriuretic peptide receptor 3 encoding plasmids and discovered a preserved fiber area as a result of restrained proteolysis. During growth of two specific cachexia-causing tumors, Musclin knockout mice lose more muscle tissue during development. Musclin may be able to assist cancer patients who cannot exercise or are at risk of cachexia, and may help to explain how aerobic exercise can improve cancer-induced muscle wasting.

Source link: https://doi.org/10.3390/cancers11101541

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions