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Although subpoena depression is more common than Major Depression among elderly adults, older adults' MDD rates have risen in the last two decades. For those with LLD, this necessitates a better understanding of the AE training's ability to produce systemic brain characteristics and cognition. It cannot be assumed that AE effects on brain health would be constant across populations with varying amounts of brain-related abnormalities. The majority of the AE brain health and cognition literature is based in the United States, where this study provides the first investigation into the extent to which AE impacts on cognitive and brain health in older adults with rLLD are similar to and distinct from AE effects on cognitive and brain health in those with rLLD. Using summary network connectivity tools, the primary analysis of resting state functional magnetic resonance fMRI results will include ANCOVAs to investigate group differences in change in within-network DMN connectivity and cross-network DMN-ECN connectivity using summary network connectivity metrics. A comparison of group differences in terms of change in objective cognitive results relative to subjective measures of cognitive functioning would also be included in exploratory studies. Pearson's correlations will be used to determine the connection between brain changes demonstrating an effect of AE training and improvements in cognitive skills in areas that show an effect of AE training.
Source link: https://clinicaltrials.gov/ct2/show/NCT04670510
While the control group will receive diet recommendations, the intervention group will get aerobic exercises in addition to diet recommendations. When patient reach to THR, the aerobic workouts in the form of treadmill training intensity of exercises moderate to vigorous will intensify, with the target heart rate increasing to 60-70% in the first 10 minutes of session 40 min.
Source link: https://clinicaltrials.gov/ct2/show/NCT05136742
The aim of this exploratory study is to provide empirical research and trials on the use of aerobic exercise training as an adjunct to improving cardiorespiratory endurance in patients with traumatic brain injury. We predict that 1 AET will raise both cardiorespiratory endurance and fatigue severity 2 mood at first in reaction to AET, but that mood reactivity will decline at some point during the trial, and that AET's specific cognitive skills focus areas of interest and concentration will expand with AET. In addition, a submaximal, continuous work rate test will be used to determine the cardiorespiratory system's ability to satisfy the demands of work over time VO2 on-kinetics. The Fatigue Severity Scale FSS is the most commonly used measurement system for the fatigue outcome variable. According to data from the Medical Outcomes Study's 36-Item Short Form MOS-36SF, Becks Depression Inventory BDI, The Pittsburgh Sleep Quality Index PSQI, The International Physical Activity Questionnaire IPAQ, and the Profile of Mood States Short Form POMS-SF will be displayed in relation to data from the Medical Outcomes Study 36-Item Short Form POMS-SF. The change in mood reactivity in the POMS-SF scores before and after 30 minutes of recovery will be measured. Change in mood reactivity as a result of time-course-related change in mood reactivity is the week of the first sign of significant improvement in mood reactivity.
Source link: https://clinicaltrials.gov/ct2/show/NCT01294332
The authors of the study: Experimental group with a Nordic walking schedule and a health monitoring group with the same program: The rehabilitation doctor's consultations will take place at the University Clinic of the Faculty of Health Sciences of Rey Juan Carlos University, Madrid, Spain, and will be included in the scope of geographical coverage. During the first four sessions of intervention, the instructor will begin designing routes without gradients for the first four sessions of intervention, and the curriculum will be modified for the next two months as a result of the groups' evolution and adapted to the needs of the longcoVID patients. During the sessions, patients will be encouraged to record post-exercise exhaustion and their heart rate and oxygen saturation. The Kolmogorov-Smirnov test will be used to determine whether the study results have normal distributions. Those quantitative variables that do not show a normal distribution will be analyzed with non-parametric tests and their results will be presented as median and interquartile ranges, while quantitative variables that show a uniform distribution will be investigated with parametric tests and standard deviations. For variables with a normal distribution, a repeated measures analysis of variance with Bonferroni will be conducted, establishing as an inter-subject factor and as an intra-subject variable each of the measurements.
Source link: https://clinicaltrials.gov/ct2/show/NCT05453188
This research is designed to investigate the 'priming' effect of aerobic fitness on a motor rehabilitation program for chronic stroke survivors. Importantly, new evidence also supports the use of AEx as a priming agent to improve motor outcomes following targeted rehabilitation. AEx's broad range of behavioral and physiological health features make it ideal to serve as an adjunctive primer to stroke rehabilitation services. More specifically, the investigators intend to pair AEx with a computerized reality rehabilitation game called Duck Punch to serve as the platform for investigating AEx's adjunctive value. Chronic stroke victims who are often affected by AEx's priming will be randomly assigned 8 weeks of DDP preceded by either 15 minutes of AEx or a stretching control, according to a stretching control. To determine the priming effects of AEx, chronic stroke victims will be randomly assigned 8 weeks of DDP preceded by either 15 minutes of AEx or a stretching control. Aim 1: Analyse the priming effects of AEx on a motor rehabilitation program for chronic stroke survivors. Aim 2: Quantify the effects of AEx priming on neuroplasticity biomarkers. However, additional stroke sequelae could exacerbate motor function's change. Depression and impaired cognitive function can adversely influence stroke recovery outcomes, and stroke recovery outcomes can be negatively influenced by decreased neuroplastic ability and BDNF. Hence, studies that explore multiple aspects of stroke recovery as well as the neurobiological underpinnings of the response to recovery would illuminate this gap in the literature and prompt the development of new hypotheses for future study. Exploratory Aim: The effect of cognitive and emotional function on motor response to AEx+DDP is explored by this report.
Source link: https://clinicaltrials.gov/ct2/show/NCT04877444
We propose a randomised study to determine the safety and effectiveness of aerobic exercise for patients with primary pulmonary hypertension or PH secondary to interstitial lung disease. This will be the first in a sequence of studies aimed at developing exercise prescription and general health recommendations for patients with advanced lung disease. Aerobic exercise training is an important therapy for nearly all cardiovascular and pulmonary disorders. Exercise rehabilitation has been established, and exercise rehabilitation has become a standard of care for patients with chronic obstructive pulmonary disease. However, basic information about exercise preparation and its therapeutic benefits is still lacking for patients with advanced lung disease in general and specifically those with PH. The NIH Clinical Center's Rehabilitation Department has developed a pulmonary rehabilitation program for this protocol, as well as providing rehabilitation services for NIH clinic patients. Patients with PH will be randomly assigned to aerobic exercise training plus education or education only therapies. The AET arm will also treat a comparison group of patients with ILD who do not have secondary PH. After enrollment in education, the subjects with PH were first randomized to the education only arm of a randomized control arm. This report provides unique opportunity to examine the effects of exercise on patients with advanced lung disease patients, as well as providing novel treatment options for these patients.
Source link: https://clinicaltrials.gov/ct2/show/NCT00678821
Women with Alzheimer's have a lower endogenous estrogen level, leading to the belief that estrogen might be neuroprotective. Several significant correlations were found between serum hormone levels and spatial ability, as shown by clear links in memory, emotional, and rewarding circuits in the brain measured with functional magnetic resonance imaging, demonstrating several significant correlations. HYPOTHESES: There are no correlations between sex hormones and various roles and markers in elderly postmenopause and diet in elderly postmenopausal women who are exposed to aerobic exercise and diet restriction in response to aerobic exercise and diet restriction in elderly postmenopausal women.
Source link: https://clinicaltrials.gov/ct2/show/NCT04492540
Patients with ILD are randomised to either an intervention that involves aerobic exercise preparation alongside patient education or a control condition that includes patient education only. Aerobic exercise training will consist of a 10-week program of controlled treadmill walking three times a week. However, there will be a secondary investigation into which participants in the control group will complete the aerobic exercise regimen. urine pregnancy testing consists of a medical history and examination; six questionnaires on health, exhaustibility, and mood; electrocardiogram; and a urine pregnancy questionnaire; and urine pregnancy testing ; and urine pregnancy tests will all be included in the testing session. A maximum treadmill test: The exercise begins at an easy level and gradually increases until the individual says he or she can no longer continue or the police determines that it is not safe to continue. To determine how well the heart is functioning and how well the muscles use oxygen, participants are provided with a mask, electrodes, and light sensors. During seated rest, a light sensor that measures the oxygen level in the muscle is attached to the calf, but a pressure cuff will be attached around the thigh. Nt-ProBNP and complete blood count were determined by a blood sample. Exercise training and education may take place at either the NIH Clinical Center in Bethesda, Maryland, or the INOVA Fairfax Hospital in Falls Church, Virginia.
Source link: https://clinicaltrials.gov/ct2/show/NCT02019641
Physical exercise, according to recent, systoscopic, and molecular studies, may lead to neuroplastic changes at the functional, structural, and molecular levels. Changes in pwPD can be attributed to a dependable medical evaluation of an intensive multidisciplinary rehabilitation program, to testing the ability of a new panel of measurable biomarkers to determine neurobiological and functional changes. In comparison to an active control group receiving a home-based self-treatment program, the aim of this study is to determine the effects of an intensive multidisciplinary, aerobic, and motor-cognitive rehabilitation regimen on accessible and measurable molecular biomarkers; balance and gait performance; motor and non-motor impairments; and cognitive impairments; and motor and non-motor impairment; and motor and non-motor impairments; and motor and non-motor impairments; and motor and non-motor and motor and motor and motor and motor and motor and motor and motor and motor and motor and motor and motor and motor and motor and motor and motor and motor and motor and motor and ae Seventy-two patients with a diagnosis of PD in accordance of MDS guidelines will be randomly assigned to either the experimental or control group.
Source link: https://clinicaltrials.gov/ct2/show/NCT05452655
The most recent scientific advisory committee had insufficient evidence to give recommendations on how the physical fitness of yoga integrates into the physical fitness guidelines. Power yoga, heart rate, skin temperature, and body mass analysis have all been done to find that power yoga could be regarded as a moderately demanding intensity workout. Most yoga classes are about 60 minutes in length, and yoga classes of that length have not been investigated. In a yoga setting, wearable activity trackers and accelerometers are also lacking data on whether wearable activity trackers and accelerometers can accurately measure heart rate and thus activity intensity.
Source link: https://clinicaltrials.gov/ct2/show/NCT05184673
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