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Acute Kidney Injury - Wiley Online Library

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Last Updated: 25 September 2022

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Olfactomedin 4 as a novel loop of Henle‐specific acute kidney injury biomarker

Abstract: Acute kidney injury is correlated with morbidity and mortality. In patients with AKI and sepsis, we expect that urine OLFM4 will rise in patients with AKI and sepsis. Urine from critically ill pediatric patients was obtained from a prospective study based on AKI and sepsis status, which was obtained from a prospective research based on AKI and sepsis status. No AKI, no sepsis; 7 had no sepsis, no AKI; 8 had no sepsis; 10 had sepsis but no AKI; 11 had sepsis, no AKI; 11 had sepsis, no AKI; and 11 had sepsis, no AKI; no AKI; 7 had no sepsis; 12 had no sepsis; 9 had no sepsis, no AKI; 7 patients had no AKI; 9 patients had no AKI; 7 patients had no sepsis; no AKI; no AKI; 10 had no AKI; and no AKI; and AKI; 10 had sepsis; and AKI; and AKI; and AKI; and AKI; and AKI; 8 patients had sepsis; no AKI; Patients with AKI had elevated uOLFM4 levels relative to no/stage 1 AKI. Those with sepsis had increased uOLFM4 when compared to no sepsis. uOLFM4 and NGAL were correlated, but some patients had elevated uOLFM4 and low NGAL, and vice versa. In some patients, uOLFM4 and NGAL were correlated, but in others not so well, suggesting that these measurements can help distinguish AKI subgroups. Given the fact that OLFM4 colocalization to human TALH, we suggest that OLFM4 be a LOH-specific AKI biomarker.

Source link: https://onlinelibrary.wiley.com/doi/10.14814/phy2.15453


Effects of different fluid management on lung and kidney during pressure‐controlled and pressure‐support ventilation in experimental acute lung injury

In experimental acute lung injury, pulmonary tensile strain during normovolemia and protective ventilation, pulmonary tensile strains during pressureu2010controlled ventilation in experimental acute lung injury under normovolemia and protective ventilation. It is not yet known if tensile stress can result in comparable relief to compressive strain in ALI under a liberal fluid approach. Endotoxin intratracheally was administered to twenty-eight male Wistar rats, who were injected with endotoxin intratracheally. Compare with CF reduced neutrophil gelatinase and interleukin antibody expression in the kidneys in PSV and PCV, according to PSV and PCV. In the new version of ALI, CF, LF, PSV, reduced lung epithelial cell damage in comparison to LF and PSV, respectively. However, LF compared to CF resulted in reduced kidney injury markers, which was not consistent with the ventilation plan.

Source link: https://onlinelibrary.wiley.com/doi/10.14814/phy2.15429


Leucine‐rich repeat kinase 2 is protective during acute kidney injury through its activation of autophagy in podocytes

Autophagy is regulated by Leucine u2010rich repeat kinase 2 as a key regulator of autophagy in a variety of cell types. We investigated the role of LRRK2+u2010autophagy in acute kidney injury and its underlying mechanism of action. Male mice aged 8–u2010week were treated with the LRRK2 inhibitor MLiu20102 and exposed to lipopolysaccharide via intraperitoneal injection or ischemia–u2013reperfusion surgery. immortalized mouse podocytes were silenced for LRRK2 by siRNA transfection and then exposed to LPS or cobalt chloride, according to cellu2010-based assays. At 12 h post-u201LPS injection and IR surgery, we observed an increase in LRRK2 expression, accompanied by increased autophagy. In mice treated with MLiu20102 in mice, the most noticeable was kidney injury. Podocytes silenced for LRRK2 demonstrated a decrease in cell viability, reduced levels of podocyte-u2010specific protein expression, and an inhibition of autophagy. Together, these results reveal the protective effects of LRRK2 during AKI via enhanced podocyte autophagy and cell viability.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/tox.23650

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions