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Acute Kidney Injury - PubMed

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Last Updated: 25 September 2022

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Too much of a good thing: A case series of rare yet pertinent causes of hypercalcaemia and acute kidney injury.

Over-the-counter versions of calcium compounds and vitamin D supplements are commonly available. We take a look at the cases of two patients, aged 52 and 34, who were hospitalized with hypercalcaemia and acute kidney injury in hospital. We emphasize the importance of recognizing exogenous vitamin D supplements and calcium compounds as rare yet treatable causes of AKI related to hypercalcaemia, as rare yet treatable causes of AKI related to hypercalcaemia, and explaining how increasing public knowledge of the risks of over-the-counter medications is critical.

Source link: https://doi.org/10.1177/14782715221103701


Hypercalcaemia and acute kidney injury: A rare presentation of seminoma.

Hypercalcaemia is common in patients with malignancy, but it is unusual in seminoma with only eight cases reported in the literature. We feature unusual case of a 36-year-old man who developed hypercalcaemia and stage 3 acute kidney disease. He underwent a renal biopsy before imaging revealed unexpected large abdominal mass that had been identified histologically as a seminoma.

Source link: https://doi.org/10.1177/14782715221103661


Decreased Monocyte HLA-DR Expression in Patients with Sepsis and Acute Kidney Injury.

Acute kidney injury is common in critically ill patients, especially those with sepsis. In monocytes of patients with sepsis, this research sought to establish a correlation between AKI and HLA-DR expression. HLA-DR expression in monocytes in patients with AKI was reduced in monocytes with AKI compared to those without AKI. The mean monocyte HLA-DR expression in patients with end-stage renal disease in patients with AKI patients was elevated without statistical significance, but without statistical significance. Conclusions: Patients with AKI had significantly reduced HLA-DR expression in monocytes compared to septic patients without AKI.

Source link: https://doi.org/10.3390/medicina58091198


Urinary Collectrin (TMEM27) as Novel Marker for Acute Kidney Injury.

Acute kidney injury in hospitalized patients of various disciplines is a leading complication among hospitalized patients of various disciplines due to various aetiologies and is closely linked to persistent kidney disease, the need for dialysis, and death. Since nephrons are not supplied with pain signals, kidney injury is mainly caused by serum creatinine with a time delay. To determine the AKI stage, changes in serum creatinine were used. Patients with AKI had significantly lower urinary collectionrin levels than those without AKI. Collectrin was found to inversely correlate with serum creatinine and AKI stages. When compared to controls without AKI, Collectrin levels were lowest in AKI stage III and significantly lower in stage II and stage I. In conclusion, urinary collectionrin is an indicator of AKI that, unlike all other commonly used AKI biomarkers, decreases with stage of AKI and therefore can be traced to a new pathogenic route.

Source link: https://doi.org/10.3390/life12091391


Biomarker-Guided Assessment of Acute Kidney Injury Phenotypes E among ST-Segment Elevation Myocardial Infarction Patients.

We investigated the incidence and potential effects of AKI phenotypes in a ST elevation myocardial infarction patient treated with primary coronary intervention. We identified 281 patients with STEMI who were treated with PCI. Patients were divided into four AKI phenotypes: no AKI, subcutaneous AKI, hemodynamic AKI, and severe AKI. MACE was on the rise between the two groups, with the highest incidence being among patients with severe AKI. Any AKI phenotype was independently associated with MACE, with an odds ratio of 4. 15 for hemodynamic AKI, 4. 51 for hemodynamic AKI, and 12. 9 for severe AKI. In conclusion, AKI is a heterogeneous disease with distinct phenotypes among STEMI patients, and the addition of novel biomarkers may help AKI phenotyping and direct future therapies.

Source link: https://doi.org/10.3390/jcm11185402


Clinicopathological Relevance of PAX8 Expression Patterns in Acute Kidney Injury and Chronic Kidney Diseases.

Immunohistochemical testing was carried out in order to determine the presence of PAX8 transcription factor in acute kidney injury and chronic kidney disease. Among 31 human kidney samples of AKI, as well as animals with induced postischemic AKI, Presence, location, and extent of PAX8 expression were investigated, as well as in animals with induced postischemic AKI. In addition, patients with PAX8 embedded within the damaged proximal tubuli should be closely monitored, since deterioration in kidney function was noted during follow-up. Ax8-rich in proximal tubular cells was also shown that myoglobin-triggered acute kidney injury followed by a significant degree of renal injury. Given these results, we can expect that PAX8 protein may play a role in the regeneration process and recovery after acute kidney injury.

Source link: https://doi.org/10.3390/diagnostics12092036


Suppression of NRF2 Activity by HIF-1α Promotes Fibrosis after Ischemic Acute Kidney Injury.

Acute kidney injury leads to a rapid decline in renal function and may occur as a result of ischemia/reperfusion injury to the tubular epithelia. The nuclear factor erythroid-2-related factor 2 pathway shields AKI and AKI-to-chronic kidney disease progression, but we previously reported that severe IRI-based diabetes reductions in mice could have reduced NRF2 activity in mice. Mild IRI raised NRF2 levels and was associated with renal rehabilitation, while severe IRI reduced NRF2 levels and resulted in progressive CKD. We introduced HIF-1b1 in HK-2 cells in nutrient-rich or nutritionally impaired conditions to mimic mild and severe ischemia. HIF-1,u03b1 activation in nutrient-deprived environments diminished NRF2 nuclear localization and activity in nutrient-deprived environments.

Source link: https://doi.org/10.3390/antiox11091810


Exercise-Induced Rhabdomyolysis Causing Acute Kidney Injury: A Potential Threat to Gym Lovers.

However, rhabdomyolysis can result in lethal diseases, most commonly acute kidney injury resulting in dialysis, disseminated intravascular coagulation, and acute compartment syndrome. We present a case of exertion-induced rhabdomyolysis causing acute renal failure in a young patient who arrived to the Emergency Room at The Kidney Center in Karachi after exercising at the gym. After six days of hospital admission, the patient was then treated with hemodialysis and was discharged.

Source link: https://doi.org/10.7759/cureus.28046


The severity of acute kidney injury correlates with plasma venom levels in Bothrops atrox envenomings.

Snakebite envenomings are present in the Brazilian Amazon, with a 90 percent incidence caused by Bothrops atrox. In patients from Bothrops SBEs in Patients from Manaus, Western Brazilian Amazon, We sought to find predictors of AKI. Of the 127 patients, 38. 6% developed AKI, with 61. 2% presenting stage I, 34. 7% presenting stage II, and 4. 1% presenting stage III severity. Edema in the affeccted limb was strongly correlated to lower risk of AKI [p = 0. 01; OR = 0. 11]. During the hospital stay, there was a strong positive correlation between circulating venom levels and the highest creatinine serum values, as well as the difference between the maximum creatinine levels and the creatinine serum values on admission. A positive correlation between serum venom levels and creatinine levels suggests a direct or indirect role of the venom toxins in AKI's pathogenesis.

Source link: https://doi.org/10.1016/j.toxicon.2022.09.010

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions