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Acute Kidney Injury - Europe PMC

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Last Updated: 25 September 2022

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Urinary NGAL, IGFBP-7, and TIMP-2: novel biomarkers to predict contrast medium-induced acute kidney injury in children.

Background Serum creatinine is unreliable in detecting acute changes in kidney function. Consequently, the aim of this research is to determine the effectiveness of combined detection of urinary neutrophil gelatinase-associated lipocalin, insulin-like growth factor binding protein-7, and tissue inhibitor of metalloproteinase-2 in children with CI-AKI. Children with intravascular injection of contrast medium were tested to see whether they can diagnose CI-AKI early enough. [IGFBP-7]*[TIMP-2] at 0. 417 2 / 1000 was the cutoff value when both urinary IGFBP-7 and TIMP-2 were used together. Conclusions The urine of children after receiving injections of contrast medium increased faster than SCr and had a high clinical value for the early diagnosis of CI-AKI in children.

Source link: https://europepmc.org/article/MED/36120960


Risk factors for acute kidney injury after Stanford type A aortic dissection repair surgery: a systematic review and meta-analysis.

Different studies reveal that the risk factors for acute kidney injury after Stanford's type A aortic dissection repair are indistinguishable. Methods: Studies looking at risk factors for AKI after TAAD reconstruction were found in four databases from inception to June 2022. AKI's risk factors included cardiopulmonary bypass time [odds ratio, 4. 89, 92 percent confidence interval], prolonged surgical time [1. 5, 95% CI, 1. 21-1. 49], and preoperative kidney injury [noticed] are among the conditions for AKI, including cardiopulmonary bypass time. . 1. 4, 95% CI, 1. 21-1. 49, 1. 50-1. 49]: the increased packed red blood cells transfusion perioperatively, increased body mass index, increased, increased fibrovascular physiograph augmentation t [o [o, 9. 89, 9. 89, 9. 89, 9. 61, 2. 48, increased 1. 20], increased packed red blood glucose transfusion, increased fibro e perioperative kidney injury physiotherapy perioperative kidney injury In patients with postoperative AKI, or 30-day mortality in hospitals with AKI were higher than in those without AKI [risk ratio, 3. 12, 95% CI, 2. 54-3. 85, p 0. 01]. Following TAAD repair surgery, reducing CPB time and pRBC transfusion, particularly in elderly or overweight people or patients with preoperative kidney injury, was vital to avoid AKI after TAAD repair surgery.

Source link: https://europepmc.org/article/MED/36036431


Interaction of hemoglobin, transfusion, and acute kidney injury in patients undergoing cardiopulmonary bypass: a group-based trajectory analysis.

Following cardiopulmonary bypass, anemia is a risk factor for acute kidney injury following cardiopulmonary bypass. It is unknown if red blood cell transfusion-enhanced hemoglobin levels play a role in low AKI rates. In RBC and non-RBC transfusion subgroups, multivariable logistic analysis and inverse probability-weighted regression were used to determine the correlations between hemoglobin and AKI. The odds ratio for AKI with trajectory 1 varied from 1. 44 to 1. 80 for trajectory 2 and 1. 45 to 1. 66 for trajectory 3, according to four logistic models, from 1. 44 to 1. 68 for trajectory 2 and 1. 85 to 1. 66 for trajectory 3. For trajectory 2 and 7. 5% for trajectory 3, with trajectory 1 as the reference. In general, the treatment effect on AKI was 5. 6% for trajectory 2 and 7. 5% for trajectory 3, with trajectory 1 as the example. Heglobin level > 9 g/dL was not associated with reduced AKI incidence in patients receiving CPB, but not in those groups without RBC transfusion. However, in patients with RBC transfusion, a rise AKI incidence was associated with elevated AKI risk.

Source link: https://europepmc.org/article/MED/35946481


A novel contrast-induced acute kidney injury mouse model based on low-osmolar contrast medium.

The contrast-induced acute kidney injury has been the third common cause of hospital-acquired acute kidney injury. This mouse model had a significant decrease in renal function, acute renal tissue damage, and increased renal tubular cell apoptosis, suggesting that LOCM is a viable inducer for CI mice models. We discovered that uninephrectomy, as well as 24 h water deprivation, and furosemide administration 20 min before the LOCM application is a feasible pretreatment to develop a new CI-AKI mouse model.

Source link: https://europepmc.org/article/MED/35938700


Predicting renal function recovery and short-term reversibility among acute kidney injury patients in the ICU: comparison of machine learning methods and conventional regression.

Background This acute kidney injury is one of the most common causes of chronic illness. By comparing logistic regression with four machine learning methods, we aimed to determine the predictors of renal function recovery and short-term reversibility after AKI. In our analysis group, a total of 12,321 critically ill adult AKI patients was included. Following AKI, renal function recovery was immediately associated with the maximum and minimum serum creatinine within 24 hours of AKI diagnosis, the minimum SCr within 24 and 12 h, and antibiotic use length were independently associated with renal function recovery. Conclusions The maximum SCr within 24 hours of AKI diagnosis was a reliable predictor of renal function restoration and AKI's short-term reversibility. Compared to the traditional regression models, the RF machine learning algorithms demonstrated a superior capability to predict the prognosis of AKI patients in the ICU.

Source link: https://europepmc.org/article/MED/35930309


Serum free fatty acid elevation is related to acute kidney injury in primary nephrotic syndrome.

This study was designed to investigate the clinical characteristics of acute kidney disease in primary nephrotic syndrome and assess the relationship between serum lipids and AKI. In this study, a total of 1028 patients diagnosed with primary NS with renal biopsy findings were included. In the postmatch samples, serum free fatty acid was a reliable predictor of AKI. FFA levels were not observed in AKI stages or other pathological groups in the AKI and non-AKI groups.

Source link: https://europepmc.org/article/MED/35912916


Disulfiram ameliorates ischemia/reperfusion-induced acute kidney injury by suppressing the caspase-11-GSDMD pathway.

Acute kidney injury is a common disease with high mortality. After IR, disulfiram caused renal dysfunction in mice and triggered pyroptosis in renal tubular epithelial cells, and caused pyroptosis in renal tubular epithelial cells. Following IR, the expression of proteins associated with the classical pyroptosis pathway and nonclassical pyroptosis pathway was upregulated. Disulfiram stymied the upregulation of nonclassical but not all classical pyroptosis pathway proteins, thus reducing pyroptosis by inhibiting the caspase-11-GSDMD pathway. HR raised intracellular ROS levels, the positive rate of PI staining and LDH measurements in MTECs, which were all reduced by disulfiram pretreatment. Moreover, we carried out a computer simulation of TIR domain of TLR4 using homology modeling and found a small molecular binding energy between disulfiram and the TIR domain. Disulfiram, according to We conclude that disulfiram can inhibit pyroptosis by antagonizing TLR4 and limiting the caspase-11-GSDMD pathway.

Source link: https://europepmc.org/article/MED/35837696


Effect of dexmedetomidine for prevention of acute kidney injury after cardiac surgery: an updated systematic review and meta-analysis.

Several research have been published to look at the effects of dexmedetomidine administration on AKI prevention. Dexmedetomidine treatment reduced AKI incidence and length of stay in the intensive care unit by a large margin, but did not modify mortality risk, length of stay in the hospital, or mechanical ventilation times, relative to the control group. In addition, the incidence of delirium among patients treated with dexmedetomidine was drastically reduced. Conclusions: After cardiac surgery, the dexmedetomidine treatment has a positive effect on preventing AKI and postoperative delirium, which greatly reduces the length of stay in the ICU.

Source link: https://europepmc.org/article/MED/35834360


Suppression of lncRNA GAS6-AS2 alleviates sepsis-related acute kidney injury through regulating the miR-136-5p/OXSR1 axis in vitro and in vivo .

Acute kidney injury is a common complication of sepsis and increases morbidity and mortality. Long non-coding RNA GAS6-AS2 was found to inflammation and apoptosis in several diseases by targeting miRNAs and downstream genes, but its role in AKI remains unclear. Hence, we speculated that GAS6-AS2 could play a role in sepsis-related AKI by regulating target genes. GAS6-AS2 and miR-136-5p, and OXSR1, assay, RNA pull-down, or goodbye assay, were all verified by a luciferase reporter assay, RNA pull-down, or RIP assay. GAS6-AS2-GAS2 was up-regulated in LPS-treated HK2 cells and the CLP-induced rat model, according to We found that GAS6-AS2 was up-regulated in both the CLP-induced rat model and the CLP-induced rat model. In vitro, the GAS6-AS2 knockdown reduced cleaved caspase-3 and bax expression, as well as increased bcl-2 expression. H&E reported that the kidney injury was minimized while in vivo, GAS6-AS2 down-regulation, reduced urinary NGAL and Kim-1 levels, serum sCr and BUN levels, and BUN measurements, and H&E revealed that the kidney injury was relieved. In vivo, the GAS6-AS2 knockdown also reduced apoptosis, inflammation, and oxidation caused by CLP.

Source link: https://europepmc.org/article/MED/35793478


Acute kidney injury after COVID-19 vaccines: a real-world study.

According to the Vaccine Adverse Event Reporting System, We wanted to investigate the occurrence of post-vaccine AKI. Methods We compiled demographic and clinical information and outcomes of reported cases from three vaccines from December 2020 to June 2021, according to our data mining project. The association of COVID-19 vaccines and AKI was investigated by Bayesian and nonprofecoral researchers. AKI cases were identified in 1133 AKI cases, according to the researchers. Based on the highest reporting odds ratio, Pfizer-BNT appeared to have a higher AKI correlation than MODERNA and JANSSEN. We found the differences in ages, comorbidities, recent illnesses, post-vaccine AKI causes, and time to AKI onset among three vaccines. Patients in Pfizer-BNT had the worst outcome with 19. 78% in MODERNA and 12. 36% in JANSSEN, with 19. 78% in MODERNA and 12. 36% in JANSSEN. In JANSSEN than in Pfizer-BNT and MODERNA, the percentage of patients on dialysis was higher in JANSSEN than in Pfizer-BNT and MODERNA. Conclusion AKI could have arisen after the COVID-19 vaccines, mainly in elderly patients.

Source link: https://europepmc.org/article/MED/35678258

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions