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Acute Kidney Injury - DOAJ

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Last Updated: 25 September 2022

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Troponins, Acute Coronary Syndrome and Renal Disease: From Acute Kidney Injury Through End-stage Kidney Disease

However, the diagnostic accuracy of cardiac troponins in patients with kidney disease has been suboptimal due to impaired troponin clearance, chronic and chronic kidney impairment, and low amounts of troponin secretion caused by concomitant cardiac muscle injury related to left ventricular hypertrophy, inflammation, and fibrosis. This paper explores the metabolism and use of cardiac biomarkers in patients with acute and chronic kidney disease. The results of a large number of kidney disease patients with high-sensitivity troponins can identify or exclude a diagnosis of ACS in the emergency room in a significant proportion of kidney disease patients, and those patients with equivocal disease may require longer in-hospital evaluation.

Source link: https://doi.org/10.15420/ecr.2019.28.2


Does Acute Kidney Injury Condition Affect Revised BAUX Score in Predicting Mortality in Major Burn Patients?

Objective: This report was designed to determine the legitimacy of the updated BAUX score for predicting mortality among the major burn patients with acute kidney disease compared to the non-AKI group. AKI in large burn patients was also of concern due to the epidemiologic and risk factors. The medical records of 144 major burn patients admitted at Siriraj Hospital's burns unit from 2010-2016 were reviewed, and vital information was retrieved. The reliability of the updated BAUX score in predicting the mortality among the major burn patients from our study was only fair.

Source link: https://doaj.org/article/f8b14031312148f792117cc9933e1adf


Acute kidney injury following cardiopulmonary bypass in JamaicaCentral MessagePerspective

Objectives: The study's aim was to describe acute kidney disease in Jamaica following cardiopulmonary bypass. Method: At the University Hospital of the West Indies, Mona, between January 1, 2016, and June 30, 2019, we performed a review of adult patients with no prior dialysis requirement undergoing cardiopulmonary bypass. To investigate the relationship between the acute kidney injury risk factors and the primary outcome, multivariable logistic regression and Cox proportional analyses were used. Kidney Disease Improving Global Outcomes II, 44% with Kidney Disease Improving Outcomes I, 33% with Kidney Disease Improving Global Outcomes II, and 24% with Kidney Disease Improving Global Outcomes III. Conclusions: Acute kidney injury in Jamaica following cardiopulmonary bypass surgery is common in Jamaica, with poor long-term results.

Source link: https://doi.org/10.1016/j.xjon.2022.05.012


Long-Term Preoperative Atorvastatin or Rosuvastatin Use in Adult Patients before CABG Does Not Increase Incidence of Postoperative Acute Kidney Injury: A Propensity Score-Matched Analysis

Methods: We conducted a retrospective cohort study to determine the prevalence of AKI in the early postoperative period following coronary artery bypass graft surgery. Following 1:1 individual matching based on propensity score, the incidence of AKI was comparable both on day 2 and day 4 after the atorvastatin group's surgery, and the rosuvastatin group's postoperative day 4 in the rosuvastatin group's postoperative day 4 in the atorvastatin group and the rosustatin group's operative day 4 was comparable both on day 2 and postoperative day 4 between the atorvastatin group and the t On postoperative day 2 and day 4, there were no statistically significant differences in terms of incidence of AKI among the rosuvastatin group and the control group, as well as between the atorvastatin group and the control group on both days, as well as between the onset of AKI after 1:1 individual matching based on propensity score between the rosuvastatin group and the control group on both day 2 and day 4; also on postoperative day 2 and day 4;.

Source link: https://doi.org/10.3390/pathophysiology29030027


Decreased Monocyte HLA-DR Expression in Patients with Sepsis and Acute Kidney Injury

This research sought to establish a link between AKI and HLA-DR expression in monocytes of patients with sepsis. HLA-DR expression in monocytes was reduced in patients with AKI than in those without AKI. The mean monocyte HLA-DR expression in patients with end-stage renal disease was elevated without statistical significance in comparison to AKI patients. There were no differences in the AGE/sRAGE ratio and plasma samples of S100A12, HMGB1, age, and sRAGE in patients with and without AKI. Patients with AKI had significantly lower HLA-DR levels in monocytes compared to septic patients without AKI.

Source link: https://doi.org/10.3390/medicina58091198


Urinary Collectrin (TMEM27) as Novel Marker for Acute Kidney Injury

Patients of various specialties hospitalized patients of various disciplines are affected by acute kidney disease, the desire for dialysis, and death. Since nephrons are not provided with pain signals, kidney damage is primarily related to serum creatinine, which is the cause of a time delay. To determine the AKI stage, changes in serum creatinine were used. Patients with AKI had significantly reduced urinary excretin levels compared to those without AKI. In stage III and stage I, collectrin levels were lowest in AKI stage III and then dramatically lower in stage II and stage I, respectively to subjects without AKI. Urine collectrin, a key to AKI, has decreased with stage of AKI and may be attributed to a novel pathogenic pathway in conclusion.

Source link: https://doi.org/10.3390/life12091391


Blood Biomarkers and Metabolomic Profiling for the Early Diagnosis of Vancomycin-Associated Acute Kidney Injury: A Systematic Review and Meta-Analysis of Experimental Studies

In pre-clinical studies of VIKI, this systematic review and meta-analysis was intended to investigate the role of blood biomarkers and metabolic profiling as diagnostic and prognostic predictors. The primary result was to examine the relationship between the presence of VIKI as determined by blood biomarkers and metabolic profiling. With the CAMARADES checklist the risk of bias was evaluated, as well as the SYRCLE's risk of bias software. Rats had four experiments for the same species, dosage, duration of vancomycin therapy, and measurement only for serum creatine and blood urea nitrogen. In comparison to controls, a statistically significant rise was observed in serum creatinine in the vancomycin group relative to controls. The serum BUN levels were not significantly different between control and vancomycin groups, although between control and vancomycin groups were not significantly different. Conclusions: A total of four studies in rodents only reported kidney injury outcomes as determined by blood biomarkers.

Source link: https://doi.org/10.3390/jpm12091397


Biomarker-Guided Assessment of Acute Kidney Injury Phenotypes E among ST-Segment Elevation Myocardial Infarction Patients

We investigated the prevalence and potential effects of AKI phenotypes among ST elevation myocardial infarction patients treated with primary coronary intervention. We had 281 patients with STEMI treated with PCI. Patients were divided into four AKI phenotypes: no AKI, subcutaneous AKI, hemodynamic AKI, and acute AKI. MACE incidence between the two groups increased gradually and significantly among patients with severe AKI. Any AKI phenotype was independently associated with MACE, with an odds ratio of 4. 15 for hemodynamic AKI, 4. 51 for hemodynamic AKI, and 12. 9 for severe AKI, according to a multivariable regression model. AKI is a heterogeneous disease with distinct phenotypes among STEMI patients, and adding novel biomarkers may be able to overcome the limitations of sCr-based AKI definitions to enhance AKI phenotyping and direct potential therapies.

Source link: https://doi.org/10.3390/jcm11185402


Acute Kidney Injury in COVID-19 Patients: Pathogenesis, Clinical Characteristics, Therapy, and Mortality

Coronavirus disease 2019 is a disease caused by infection with the SARS-CoV-2 virus, and has been one of humanity's biggest challenges in recent years. Though the majority of harm is in the lungs, the kidneys are not excluded, and acute kidney disease can occur in patients with COVID-19. COVID-19 AKI's prevalence is variable, and the exact mechanisms of how the virus damages the kidney are still unclear.

Source link: https://doi.org/10.3390/diseases10030053


Clinicopathological Relevance of PAX8 Expression Patterns in Acute Kidney Injury and Chronic Kidney Diseases

Immunohistochemical testing was conducted in order to investigate the presence of PAX8 transcription factor in acute kidney injury and chronic kidney disease. Among 31 human kidney samples of AKI, as well as animals with induced postischemic AKI, were investigated by analyzing both location and severity of PAX8 expression. In addition, patients with PAX8 detected within the contaminated proximal tubuli would be closely monitored, since kidney function decline was noted during follow-up. In proximal tubular cells, we also showed that myoglobin-triggered acute kidney injury and a significant degree of renal damage. Given these findings, we can safely assume that PAX8 protein may play a role in the regeneration process and recovery after acute kidney injury.

Source link: https://doi.org/10.3390/diagnostics12092036

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions