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Acute Kidney Injury - Crossref

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Last Updated: 25 August 2022

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Endothelin system expression in the kidney following cisplatin-induced acute kidney injury in male and female mice

The chemotherapeutic agent cisplatin accumulates in the kidney and promotes acute kidney injury in the kidney. Young female mice and women have greater recovery from cisplatin-AKI than both young male mice and men, according to preclinical and scientific studies. The endothelin and ET receptors in the kidney are enriched in the kidney and may be dysfunctional in cisplatin-AKI; however, there is still no evidence on the renal ET system from the putative effects of sex and cisplatin. We predict that the renal ET system in cisplatin-AKI male and female mice will have increased expression of the renal ET gene. All cisplatin-AKI mice had kidney disease and body weight loss greater than control mice, as expected. Consequently, RNA profiles of the ET system were highly affected by cisplatin-AKI throughout the kidney, regardless of sex, and this may help determine the therapeutic feasibility of targeting the ET receptors in cisplatin-AKI.

Source link: https://doi.org/10.1139/cjpp-2022-0126


A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial

In an Acute Kidney Injury trial, the Standard versus Accelerated Initiation of Renal-Replacement Therapy compared two methods of KRT initiation in critically ill patients with acute kidney disease, with reported neutral results for 90-day all-cause mortality in 90-day all-cause mortality. Results The prior used randomized versus a traditional KRT initiation scheme for the primary endpoint showed no significant difference in the posterior likelihood of benefit compared to a traditional KRT initiation scheme for the primary endpoint. Patients enrolled in the accelerated program had a lower number of KRT-free days than before, with a likelihood that the revised approach resulted in more KRT-free days of 0. 008. Hospital-free days were similar to hospital-free days, with the accelerated approach offering a median absolute difference of 0. 48 more hospital-free days compared to the standard framework, and the likelihood that the accelerated program had more hospital-free days being 0. 66 percent higher.

Source link: https://doi.org/10.1186/s13054-022-04120-y


Risk factors and outcomes of neonates with acute kidney injury needing peritoneal dialysis: Results from the prospective TINKER (The Indian PCRRT-ICONIC Neonatal Kidney Educational Registry) study

Background: In neonates admitted to neonatal intensive care units, acute kidney injury is common. In neonates, there is a need to have current and reliable information regarding acute peritoneal dialysis. Worse outcomes have been seen in this population compared to older populations, as well as a longer stay in the NICU and/or hospital. According to the Neonatal Kidney Disease: Improving Global Outcomes Criteria, AKI was defined. Among neonates with AKI, the chances of needing PD were significantly higher among those with significant cardiac disease, inotropes use, critical peripartum disease, necrotizing enterocolitis, any degree of intraventricular hemoglobo, any degree of intraventricular haemorrhage, evidence of fluid overload during the first 12 h in NICU, and the need for resuscitation in the delivery room. Compared to those without PD, AKI neonates with PD had a significantly shorter median length of stay in NICU, but significantly higher mortality. Conclusions: This is the most comprehensive, multicentre study specifically focusing on neonatal AKI and neonatal dialysis in neonates. Compared to AKI neonates without PD, AKI neonates with PD had a significantly higher risk of mortality than AKI neonates without PD. To develop AKI and the desire for PD, it is imperative to keep a close eye in neonates with risk factors.

Source link: https://doi.org/10.1177/08968608221091023


Complications of Bariatric Surgery Including Rhabdomyolysis with Acidosis and Acute Kidney Injury

Abstract bariatric surgery has become more common. According to new results, 35. 9% of the adult population in the United States meets the criteria for morbid obesity, which is typically defined as a body mass index greater than 35 percent or weight 100% higher than average body mass index. The morbidly obese patient can pose significant problems in terms of perioperative airway and ventilation control, positioning, and cardiovascular risk factors.

Source link: https://doi.org/10.1093/med/9780190885939.003.0025


The future for diagnostic tests of acute kidney injury in critical care: evidence synthesis, care pathway analysis and research prioritisation

Background The acute kidney injury in hospital inpatient populations is highly prevalent, contributing to increased mortality and morbidity, reduced quality of life, and high short- and long-term health-care costs for the NHS. AKI in vitro diagnostic tests can be used to enhance patient care of patients admitted to the intensive care unit, as well as identify a cost-effective supporting research strategy. Methods used in the study of information retrieval from a UK NHS perspective and value of information analysis. The AKI-Diagnostics project included horizon scanning, systematic review, meta-analysis, regression of sensitivity and specificity, evaluation of analytical reliability, care pathway analysis, and a value of information analysis. Conclusions Diagnostic studies in AKI in the ICU have the ability to enhance patient care and add value to the NHS, but cost-effectiveness remains very unclear. Further studies should explore how a new test can influence current care procedures in the ICU, as well as the subsequent cost and QALY implications. According to the VOI's report, more observational study to better determine AKI development in the ICU would be useful. To determine whether or not adoption of tests by the NHS will be of value, a formal randomised controlled trial relating to a standardised AKI care pathway is required. registration of studies Within this report The systematic review of this study has been designated as PROSPERO CRD42013919. Funding for the National Institute of Health Research Health Technology Assessment (NIH) The National Institute for Health Research Health Technology Assessment project was funded by the National Institute for Health Research Health Information.

Source link: https://doi.org/10.3310/hta22320


Interleukin 1 receptor (IL-1R1) activation exacerbates toxin-induced acute kidney injury

AKI can be caused by a variety of therapeutic agents, including drug-induced/toxic AKI. Although tumor necrosis factor-u03b1 plays a significant role in the pathogenesis of cisplatin nephrotoxicity, TNF production in this setting does require clarification. We therefore hypothesized that IL-1R1 activation promotes AKI by inducing TNF production, raising inflammatory signals between kidney parenchymal cells and infiltrating myeloid cells. Compared to WT mice, IL-1R1 KO mice had attenuated AKI as measured by serum creatinine and BUN, renal NGAL mRNA levels, and blinded histological examination of kidney pathology. TNF-injured kidney TNF reductions were reduced in IL-1R1 KO mice's cisplatin-injured kidneys, with reduced numbers of whole kidney TNF and fewer Ly6G-expressing neutrophils in the cisplatin-injured kidney. In addition, an improved number of CD11b int myeloid cells in IL-1R1-KO injured kidneys showed a reduced number of CD11b/CD11c int myeloid cells in IL-1R1 KO injured kidneys relative to IL-1R1 WT kidneys, as well as IL-1R1 WT kidneys.

Source link: https://doi.org/10.1152/ajprenal.00104.2018


Dexmedetomidine and acute kidney injury following cardiac surgery in pediatric patients—An updated systematic review and meta-analysis

Dexmedetomidine has the pharmacological characteristics of organ protection in cardiac surgery patients, according to the pharmacological characteristics of organ protection. The aim of this meta-analysis is to determine the effect of dexmedetomidine infusion on AKI after cardiac surgery in pediatric patients. Patients with dexmedetomidine and placebo exhibited a significant difference in the incidence of AKI among patients with or without a fixed-effects model with OR. The results in pediatric patients receiving intraoperative or postoperative dexmedetomidine infusion did not show a significant difference between AKI in pediatric patients receiving intraoperative or postoperative dexmedetidine infusion, but there was a significant difference in patients receiving a mixture of intra- and postoperative dexmedetomidine infusion. Conclusion Compared to placebo, dexmedetomidine could significantly reduce the postoperative incidence of AKI in pediatric patients undergoing cardiac bypass surgery using cardiopulmonary bypass, but the significant difference was evident in pediatric patients receiving a combination of intra- and postoperative dexmedetomidine infusion.

Source link: https://doi.org/10.3389/fcvm.2022.938790


A Meta-Analysis of Randomized and Observational Studies: Aspirin Protects from Cardiac Surgery-Associated Acute Kidney Injury

Background: Antiplatelet therapy is highly recommended in the treatment of coronary artery diseases. Preoperative antiplatelet therapy concerning bleeding risk remains for patients undergoing cardiac surgery, including coronary artery bypass graft and valve replacement. Preoperative aspirin, according to new studies, may have a protective effect on cardiac surgery-associated acute kidney injury. Objective: To determine the effectiveness of preoperative aspirin in preventing CSA-AKI. These studies compared preoperative aspirin to placebo/no aspirin, and showed the lowest incidence of CSA-AKI. Aspirin in five days before cardiac surgery reduced post-operative renal failure [odds ratio, 0. 67; 95% confidence interval, 0. 50-0. 89] and 30-day mortality compared to 30-day mortality, according to the data retrieved. Aspirin should be shielded from major adverse cardiocerebral events, according to One RCT and three OSs. Aspirin, according to One RCT and two OS, did not increase the risk of re-exploration for bleeding.

Source link: https://doi.org/10.1532/hsf.2419


Preoperative Urinary pH is Associated with Acute Kidney Injury After Cardiac Surgery in Non-Diabetic Patients

Background: Acute kidney injury is a common complication of cardiac surgery and increases morbidity and mortality. The current research seeks to determine the relationship between preoperative urinary pH levels and acute kidney injury following isolated coronary artery bypass graft surgery. Patients with preoperative urinary pH=5. 5; Group I, patients with preoperative urinary pH=5. 5; Group II, patients with preoperative urinary pH=5. 5; and Group IV, patients with preoperative urinary pH=6-6. 5; and Group IV, patients with preoperative urinary pH=7. 0, respectively. 108 patients in Group I, 44 patients in Group II, 78 patients in Group III, and 40 patients in Group IV were among them. In 39 patients in Group I, 4 patients in Group II, and 2 patients in Group III, there was an acute kidney injury. In Group IV, none of the patients had AKI.

Source link: https://doi.org/10.1532/hsf.2509


The Perioperative Hyperchloremia Is Associated With Postoperative Acute Kidney Injury in Patients With off-Pump Coronary Artery Bypass Grafting: A Retrospective Study

Background: The connection between perioperative hyperchloremia and postoperative acute kidney injury is not well established. In patients undergoing off-pump coronary artery bypass grafting, our study sought to determine the connection between perioperative hyperchloremia and acute kidney injury. Patients with coronary disease who underwent off-pump CABG between April 2017 and December 2019 were included in this retrospective study. Patients with perioperative hyperchloremia were matched 1:1 to patients without perioperative hyperchloremia. The most notable result was the postoperative acute kidney injury rate. Results: The study included a total of 321 patients who underwent off-pump CABG, as well as off-pump CABG. For the final comparison, the Propensity score matching selected 83 pairs was used. The results revealed that the postoperative AKI incidence was markedly different between the hyperchloremia and no hyperchloremia groups. Conclusions: Perioperative hyperchloremia is correlated with an rise in the postoperative AKI rate in patients undergoing off-pump CABG.

Source link: https://doi.org/10.1532/hsf.3443

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions