Advanced searches left 3/3

Acute - Europe PMC

Summarized by Plex Scholar
Last Updated: 26 January 2023

* If you want to update the article please login/register

Chronic impact of exposure to low dissolved oxygen on the physiology of Dicentrarchus labrax and Sparus aurata and its effects on the acute stress response

Fish growth and survival are influenced by dissolving oxygen saturation in the water. Sparus aurata were reared for approximately three months at various DO saturation levels, including 40-60%, 60-60%, and 80 percent at a temperature of 26. 5 °C. Do saturation in Dicentrarchus affected Hematocrit, hemoglobin, and mean corpuscular hemoglobin concentrations. In both species, Cortisol levels in fish plasma and scales were similar, but in plasma, it was elevated after acute stress exposure. Diabetes and lactate were both adversely affected by acute stress in low oxygen saturation in D. labrax, according to multivariate analysis, although osmolality was predominant in S. aurata. Overall, this review gave more detail into the effects of DO in the physiology of D. labrax and S. aurata.

Source link: https://europepmc.org/article/MED/IND607936345


Are resistances to acute hyperthermia or hypoxia stress similar and consistent between early and late ages in rainbow trout using isogenic lines?

Global warming is expected to rise the frequency and intensity of heatwaves, resulting in more frequent combined acute hyperthermia and hypoxia in fish farms. We looked at the ranking stability of genotypes for acute hyperthermia or hypoxia resistances over time, as well as between acute hyperthermia and acute hypoxia resistances. To this end, we created a list of six isogenic lines of rainbow trout for their sensitivity to acute hyperthermia and hypoxia stress factors at 6 and 15 months. These characteristics were found in genetic analysis of these traits. There were statistically significant resistance differences among lines confirming the possibility of genetic mutation for these traits. acute hyperthermia and hypoxia resistance traits were found in several lines, but others were insensitive to one while others were not: resistant to one but not sensitive to the other. This indicates that there are no strong differences between acute hyperthermia and hypoxia resistance characteristics in rainbow trout, which is not surprising.

Source link: https://europepmc.org/article/MED/IND607930341


Acute kidney injury after arterial switch operation: incidence, risk factors, clinical impact - a retrospective single-center study.

Background This retrospective research sought to determine the incidence, risk factors, and consequences of acute kidney injury in neonates following the arterial switch operation for transposition of large arteries. Methods The Ukrainian Children's Cardiac Center's retrospective analysis of medical records of children who underwent ASO in 2019-2020. In the non-severe AKI group, longer cross-clamp time was recorded: 82 versus 73. 5. paraphrasedoutput AKI, which is the product of our study, 47 percent of patients developed AKI after ASO, 25. 8%-severe AKI.

Source link: https://europepmc.org/article/MED/36692196


Exploring the pharmacological mechanisms of Shuanghuanglian against T-cell acute lymphoblastic leukaemia through network pharmacology combined with molecular docking and experimental validation.

Materials and methods SHL was administered to 24 and 48 h. The controls were administered with SHL 940, which contained 10% foetal bovine serum. Cell viability was determined by Cell Counting Kit-8 assay assay. At 48 h and 0. 30 mg/mL, respectively, as a result of T-ALL, 117 target genes of SHL were found in apoptosis and NOTCH signalling pathways, with IC 50 values of SHL in Jurkat and Molt4 cells most enriched in the apoptosis and 0. 07 mg/mL. The protein content of cleaved caspase-7 and cleaved PARP were significantly enhanced, but those of cleaved NOTCH1 and MYC were reduced. SHL promotes apoptosis in T-ALL cells through the NOTCH1-MYC pathway, and may be a potential treatment for T-ALL.

Source link: https://europepmc.org/article/MED/36656546


Da-Yuan-Yin decoction polyphenol fraction attenuates acute lung injury induced by lipopolysaccharide.

Objectivise : This review investigates the clinical effects of the Da-Yuan-Yin decoction polyphenol fraction on acute lung injury in mice induced by lipopolysaccharide. The changes of IL-4 and IL-10 were decreased in the lung W/D ratio, total protein ratio, C3c and C5a, as well as C3c and C5a. The C5aR1, C5b-9, and COX-2 mRNA, the expression of MPO and iNOS mRNA, the development of the IKK/NF-u03baB pathway, was decreased, as well as increased the amounts of IL-13 and SOD. The DYY-4-reparted the lung tissue pathological changes and reduced the C3c deposition.

Source link: https://europepmc.org/article/MED/36655330


Characteristics and risk factors for renal recovery after acute kidney injury in critically ill patients in cohorts of elderly and non-elderly: a multicenter retrospective cohort study.

Background The aim of this research was to determine the risk factors for renal nonrecovery among elderly and nonelderly patients with acute kidney injury in critically ill patients. Both patients were divided into two cohorts, age 63 and age 67, respectively, as a result of renal transplantation at 30 days after AKI; the two patient cohorts were further divided into a renal recovery group and a renal nonrecovery group. Patients aged 63 years old (AKI stage), blood lactate level, and hemoglobin level were among the key risk factors contributing to renal nonrecovery in patients aged 63 years old, according to a multivariate analysis.

Source link: https://europepmc.org/article/MED/36651696


Explainable machine learning model for predicting furosemide responsiveness in patients with oliguric acute kidney injury.

Despite the fact that current guidelines don't endorse the use of furosemide in oliguric acute kidney injury prevention, several patients may be benefited from furosemide therapy at an early stage. Methods From Medical Information Mart for Intensive Care-IV and EICU Collaborative Research Database, oliguric AKI patients with urine output 0. 5 ml/h for the first 6 hours after ICU admission and furosemide infusion u2265 40 mg in the corresponding 6 h were retrospectively selected. During 6-24 h following the initial 6 h for assessing oliguria, the MIMIC-IV cohort was used in developing a XGBoost model to forecast UO > 0. 65 ml/h during 6-24 h, which was confirmed in the eICU-CRD cohort. We compared the predictive results of the XGBoost model with those simulated logistic regression and other ML models. In oliguric AKI, a simplified ensemble model can be used to accurately distinguish between patients who will and will not respond to furosemide.

Source link: https://europepmc.org/article/MED/36645039


Acute pyelonephritis in pregnancy and plasma syndecan-1: evidence of glycocalyx involvement.

In women with acute pyelonephritis in the presence or absence of bacteremia, the aim of this study was to determine whether the plasma syndecan-1 concentration changes in women with acute pyelonephritis. Based on medical findings and a positive urine culture for bacteria, acute pyelonephritis was diagnosed. In 85% of women with acute pyelonephritis, blood culture results were available. Women with uncomplicated pregnancy had a higher plasma concentration of syndecan-1 than non-pregnant women. In normal preterm gestation tests, the geometric mean of syndecan-1 concentration was 51. 0 ng/mL; 1280 ng/mL in average term gestations; and 1786 ng/mL in normal term gestation; and 1786 ng/mL in normal term gestations; and 1786 ng/mL in normal term gestation; plasma syndecan-1 concentrations remained elevated than those in normal pregnant women with acute pyeloneph The increase was mainly owing to cases with a positive blood culture,; when third-trimester samples were compared, overall differences in syndecan-1 MoM values were marginally higher, largely due to cases with a positive blood culture, which were especially relevant in cases with a positive blood culture. Patients with acute pyelonephritis have a higher blood concentration of syndecan-1, which is particularly true in the presence of bacteremia.

Source link: https://europepmc.org/article/MED/36642424


The attributable mortality of sepsis for acute kidney injury: a propensity-matched analysis based on multicenter prospective cohort study.

Background Both sepsis and AKI are diseases of significant concern in the intensive care unit. On day 1, day 2, and day 3-5, the Propensity score was sequentially calculated to match AKI patients with and without sepsis. 619 of the 1010 AKI patients with sepsis were compared to 619 AKI patients in whom sepsis did not develop during the screening period. 205 of 619 for their matched AKI controls without sepsis at matched AKI controls. Total sepsis among AKI patients was 9. 9% attributable mortality of attributable sepsis. 328 patients with sepsis were diagnosed with septic shock. The AKI's attributable mortality of septic shock was 16. 2%. AKI's attributable hospital mortality of total sepsis was 9. 1%, according to the authors. AKI's greater mortality rate than sepsis is due to septic shock rather than sepsis.

Source link: https://europepmc.org/article/MED/36637012

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions