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Last Updated: 26 November 2022

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First-pass effect in patients with acute vertebrobasilar artery occlusion undergoing thrombectomy: insights from the PERSIST registry

Background: Patients with acute large vessel occlusion can be able to recover rapidly and completely, as shown by the following study. Mission: We wanted to investigate the possibility of the first-pass effect on patients with acute vertebrobasilar artery occlusion. Methods: We retrospectively reviewed the results of patients who underwent endovascular thrombectomy caused by VBAO in a multicenter retrospective registry database. After one pass of the device without rescue therapy, successful recanalization [modified thrombolysis in cerebral infarction 2b/3 as modified FPE] was identified as successful recanalization [modified thrombolysis in cerebral infarction 2b/3 as modified FPE, mTICI 3 as genuine FPE] [modified FPE], defining successful recanalization [modified FPE in cerebral infarction 2b/3 as new FPE; mTICI 3 as updated FPE; mTICI 3 as true FPE [modified FPE] as modified FPE [modified FPE [modified FPE; upgraded FPE [modified FPE; modified FPE; updated FPE; modified FPE; modified FPE; upgraded FPE; modified FPE; thrombolysis in cerebral in cerebral in cerebral in 2b/3 as modified FPE; thrombolysis in cerebral in cerebral in cerebral in cerebral in cerebral infarction 2b/3 as modified FPE; n FPE; thrombolysis in cerebral in 2b/3 as revised FPE; mPE; To investigate the predictors of FPE and the connection between FPE and 90-day prognosis, multivariate analysis was used. An intravenous recombinant tissue plasminogen activator prior to EVT was a promising predictor of mFPE but not of tFPE. Conclusion: FPE was associated with highly positive outcomes in EVT patients with VBAO.

Source link: https://doi.org/10.1177/17562864221139595


Does Acute Kidney Injury Condition Affect Revised BAUX Score in Predicting Mortality in Major Burn Patients?

Objective: This report was designed to determine the validity of the updated BAUX score for predicting mortality among the major burn patients with acute kidney injury compared to the non-AKI group. Important information was retrieved from the medical records of 144 major burn patients admitted at Siriraj Hospital's burns unit from 2010-2016, which included significant findings. AKI in burn patients was also high, with high mortality rates in burn patients. The accuracy of the updated BAUX score in predicting the mortality among the major burn patients from our study was only fair.

Source link: https://doaj.org/article/f8b14031312148f792117cc9933e1adf


Ocular Manifestations in Acute Herpes Zoster Ophthalmicus

Ocular inflammation in acute herpes zoster ophthalmicus was 71%. The best predictor of ocular inflammation in acute herpes zoster ophthalmicus was Nasociliary skin lesions. A period of longer than four days from the onset of rash to an eye examination, and the introduction of systemic acyclovir therapy after three days from rash onset was confirmed. Conclusion: There is a high incidence of ocular inflammation in acute herpes zoster ophthalmicus, especially among people with Hutchinson's sign and delayed systemic acyclovir therapy.

Source link: https://doaj.org/article/c642526ca176459d86feab8dd351d0ab


The Development of Personalized Medicine: Acute Myeloid Leukemia as a Model

The word personalized medicine has been used in a variety of contexts and has emerged as one of the most commonly used keywords lately. In this review, we explore whether diagnostic medicine and therapeutics can be applied to patients with the intention of eradicating disease or relieving symptoms in a manner in which all recommendations are based on thorough knowledge of the individual patient's health. The former is based on the facts that for several disorders u201cless, but more targeted u201d will result in improved outcomes. Acute myeloid leukemia is the most common acute leukemia in adults, and it is a major challenge in terms of diagnosis, care, follow-up, and therapy. AML has been extensively researched during the past two decades for these reasons. Lastly, drugs targeted to the patient's molecular changes are now being tailored, based on knowledge of these factors in the single patient cytoreduction.

Source link: https://doaj.org/article/d99ceabf46b546e3b337906951285284


Predicting the Need for Continuation of N-acetylcysteine Treatment among Acute Paracetamol Overdose Patients with Psi Parameter

This is a retrospective examination of patients with acute paracetamol overdose at Siriraj Hospital between 2007 and 2016. Materials and methods: This is a retrospective review of patients with acute onset bronchio syndrome who were treated with NAC at Siriraj Hospital between 2007 and 2016. Indications for NAC continuation are in accordance with the rules, which requires that NAC therapy be continued if the follow-up aminotransferase reached 50 U/L or higher. Psi was shown to be a reliable predictor of NAC extensionation in the area under the receiver's operational characteristics curve, 0. 766. Conclusion: AcetaCalc's Psi parameter is a useful tool in predicting cases where NAC therapy beyond the standard protocol is indicated.

Source link: https://doaj.org/article/c17ae537e1c04675867057bddf48f45f


User experience of self‐reported computerized medical history taking for acute chest pain: The Clinical Expert Operating System Chest Pain Danderyd Study

Abstract Background and Objective Chest Pain is one of the most common complaints in emergency departments. Self-u2010reported computerized history taking statistics can be used to determine the clinical value of medical data obtained directly from patients. Patients' reactions and attitudes to the technology, as well as their expectation that the equipment will have benefits for their medical care, are factors that influence clinical practice. Patients attending an ED for acute chest pain in the setting of patients attending an ED for acute chest pain, the study sought to investigate the user experience of the self-u2010reported CHT program Clinical Expert Operating System. Methods This qualitative interview survey is part of the ongoing CLEOSu2010Chest Pain Danderyd study. The results show that CHT programs can be integrated as a standard method for gathering self-u2013reported medical history data in the ED setting, according to the authors.

Source link: https://doi.org/10.1111/hex.13612


Investigation of the association between serum uric acid levels and HEART risk score in patients with acute coronary syndrome

Abstract: For a long time, the relationship between uric acid and cardio-u2010metabolic disorders has existed. Data regarding the pharmacologic role of UA in acute coronary syndrome is scarce in this light. The serum level of UA was measured at the time of admission to the hospital. Between the measured UA level and the calculated HEART score was found to be a positive yet statistically insignificant relationship. However, further research with larger sample size is required to determine the direct correlation of UA level with key adverse cardiac events in patients with cardiovascular disease.

Source link: https://doi.org/10.14814/phy2.15513


Right ventricular energy metabolism in a porcine model of acute right ventricular pressure overload after weaning from cardiopulmonary bypass

Abstract : Following congenital heart surgery, right ventricular pressure overload occurs most commonly resulting in low cardiac output syndrome. After cardiopulmonary bypass, we tested the hypothesis that the RV has no ability to modify substrate utilization in reaction to increasing energy requirements during acute RVPO. By pulmonary artery banding and CPB, we investigated the RV fractional contributions of substrates to the citric acid cycle in juvenile pigs exposed to acute RVPO in juvenile pigs exposed to acute RVPO. With PAB, sixteenteen Yorkshire male pigs were randomly assigned to SHAM, 2u2010h CPB, or CPB with PAB. In PAB'u2010CPB, RV systolic pressure doubled from baseline, despite the fact that piglets in CPB's CPB group maintained normal RVSP. Following CPB, an appropriate energy supply and metabolic interventions may be needed to avoid these RV energy metabolic abnormalities during RVPO.

Source link: https://doi.org/10.14814/phy2.15421


Ferulic acid alleviates alveolar epithelial barrier dysfunction in sepsis-induced acute lung injury by activating the Nrf2/HO-1 pathway and inhibiting ferroptosis

Results In sepsis-induced ALI, FA decreased the lung injury score, lung wet/dry weight ratio, and myeloperoxidase production in sepsis-induced ALI, according to FA. FA's protective role against alveolar epithelial barrier dysfunction could be reversed by the ferroptosis inducer Fe-citrate, which is believed to have reduced FA's alveolar epithelial barrier dysfunction by inducing ferroptosis.

Source link: https://doi.org/10.1080/13880209.2022.2147549


Combination of distal radio-ulnar joint disruption associated with an acute Monteggia fracture - A case report

This Case paper is highlighting one such rare occurrence of MFD associated with longitudinal instability of the forearm. We report an acute case of a Monteggia fracture with distal radio-ulnar joint dysfunction in a 21-year-old male, driver by occupation. He was treated by 3. 5 mm dynamic compression plate, closed reduction of the radio-capitellar joint, and percutaneous K-wire fixation for distal radio-ulnar joint instability, as a result of open reduction and internal fixation of ulna shaft fracture by 3. 5 mm dynamic compression plate, distal radio-ulnar joint instability.

Source link: https://doi.org/10.1016/j.jorep.2022.03.003

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions