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Acne Treatment - PubAg

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Last Updated: 16 October 2021

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Chitosan nanoparticles making their way to clinical practice: A feasibility study on their topical use for acne treatment

The topical qualities of chitosan nanoparticles were confirmed, in which they displayed solid skin bond ex vivo and high nicotinamide deposition in the various skin layers amounting to a total of 68%. When clinically examined on patients, nicotinamide nanoparticles showed 73% reduction in the inflammatory acne lesions compared to unattended areas, for this reason confirming that chitosan nanoparticles can be a medically seeming choice for treatment of skin diseases.

Source link: https://pubag.nal.usda.gov/catalog/6883462


Topical gel with ethyl cellulose based microsponges loaded with clindamycin hydrochloride for acne treatment

This research describes development of a dose form for acne treatment. A topical semi-solid dosage form-- gel with clindamycin-hydrochloride packed ethyl cellulose based microsponges. Central composite experimental style was utilized for optimization of the solution in methods of fragment size and medication loading. CM-HCl MSP optimum formula was prepared and defined in aspect of: fragment dimension and bit dimension distribution; shape and morphology; FTIR ranges; medication content and medication launch with mean dissolution time of 4. 51 h. Chitosan was made use of as a gelling agent for the optimum sample formula.

Source link: https://pubag.nal.usda.gov/catalog/7123204


Iontophoresis mediated localized delivery of liposomal gold nanoparticles for photothermal and photodynamic therapy of acne

Acne is among the typical skin-related skin inflammatory conditions. The rising instance of antibiotic resistance in acne stress has caused the exploration of different healing methods. In the existing study, we have used a liposomal gold nanoparticle alluring curcumin for twin light-mediated therapy for the treatment of acne. Hence the twin light-mediated therapy by Au Lipos Cur NPs can form a possible therapeutic modality for the effective treatment of persistent acne.

Source link: https://pubag.nal.usda.gov/catalog/7288293


Combining Visible Light and Non-Focused Ultrasound Significantly Reduces Propionibacterium acnes Biofilm While Having Limited Effect on Host Cells

Microbial biofilms are very immune to anti-biotics and have been implicated in the etiology of 60%-- 80% of persistent microbial infections. We tested a novel combination of reduced intensity ultrasound and blue light versus biofilm and planktonic microorganisms. Coincident distribution of both energies demonstrated synergy over either alone, killing both fixed planktonic and biofilm societies of P. acnes. Decrease in biofilm microorganisms was dosage depending on exposure time. P. acnes biofilms were considerably lowered by twin energy treatment, with a > 1 log ₁₀ reduction after a 5 minutes and > 3 log ₁₀ decrease after a 30 min treatment.

Source link: https://pubag.nal.usda.gov/catalog/7388370


The effects of green tea on acne vulgaris: A systematic review and meta‐analysis of randomized clinical trials

Green tea remove has been examined for the treatment of acne based on its anti‐inflammatory/ antioxidant properties. Although GTE did not significantly lower the variety of non‐inflammatory sores, when stratified by the path of admission, non‐inflammatory acne sores were considerably reduced by topical GTE application but not with oral GTE administration. This systematic review and meta‐analysis recommend that topical GTE application is advantageous for the treatment of acne without causing significant adverse events while oral GTE intake has limited effects.

Source link: https://pubag.nal.usda.gov/catalog/7257206


Extracts from Cephalaria Uralensis (Murray) Roem. & Schult. and Cephalaria Gigantea (Ledeb.) Bobrov as Potential Agents for Treatment of Acne Vulgaris: Chemical Characterization and In Vitro Biological Evaluation

The objective of this research was to contrast the chemical structure, as well as antioxidant, anti-inflammatory, antiacne, and cytotoxic activites of various extracts of Cephalaria gigantea and C. uralensis. It is worth underscoring that we are the first to identify the composition and review the biological properties of extracts from Cephalaria gigantea and C. uralensis. Among the tested examples, ethanol extract of the airborne components of C. uralensis had the most suitable biological properties. Taking into consideration the value of computed restorative index, it is worth keeping in mind that CUE can be based on in vivo research study.

Source link: https://pubag.nal.usda.gov/catalog/7116366


Susceptibility of Cutibacterium acnes to topical minocycline foam

FMX101 4% minocycline foam is an unique, topical minocycline formulation for treatment of acne vulgaris. We report that FMX101 4% had an MIC ₉₀ of 0. 25 μg/ ml and was ≥ 4-fold more active than comparator antimicrobials against a panel of 98 medical Cutibacterium acnes isolates. The panel varied by clonal complicated and sequence type, having 20 novel multi-locus sequence types consisting of clonal complicateds and series types associated with acne. Minocycline preserved anti-bacterial task versus C. acnes over 15 numerous flows; hence, no discerning growth benefit for minocycline-resistant mutants took place under the experimental problems. FMX101 4% has the potential to maintain the positive resistance profile of minocycline in diverse C. acnes isolates while giving the advantages of a topical solution for treatment of acne vulgaris.

Source link: https://pubag.nal.usda.gov/catalog/6837060


Saponin fraction from Sapindus mukorossi Gaertn as a novel cosmetic additive: Extraction, biological evaluation, analysis of anti-acne mechanism and toxicity prediction

Evidence-based medicine also verified the antimicrobial, anti-acne and anti-tyrosinase task of S. mukorossi essence, suggesting that it has the prospective to be a pharmaceutical and aesthetic additive. The present study was intended to assess the freckle-removing and skin-whitening tasks of S. mukorossi extracts, and additionally evaluating the prospective anti-acne mechanism. Saponin portions were detoxified by utilizing the semi-preparative high-performance liquid chromatography, and their anti-bacterial task was identified versus Propionibacterium acnes, which was the leading reason for irritated lesions in acne vulgaris. Active elements of saponin fraction were recognized by HPLC-MS analysis. The different toxicity level of compounds was predicted according to the quantitative structure-activity relationship, and the first application of crude extract and saponin fraction to facial masks was examined based on the comprehensive analysis method. The saponin fraction detoxified from the fermentation liquid-based water extract showed the finest anti-bacterial activity versus P. acnes ATCC 6919 with the MIC of 0. 06 mg/mL, which was 33-fold of its moms and dad SWF. Compared with SWF, the application of F4 caused greater restraint rates on lipase and tyrosinase. Chemical constituents of F4 were reviewed, from which 4 oleanane-type triterpenoid saponins were discovered to add to the above organic tasks of F4. The mechanism of the 4 substances on anti-acne was predicted, and 7 targets such as PTGS2 and F2RL1 were gotten to be vital for the treatment of acne. These searchings for will assist in the development of the S. mukorossi essence and the allied products as the new and natural anti-acne agent and aesthetic additives.

Source link: https://pubag.nal.usda.gov/catalog/7162094


Inhibitory Effects of a Sargassum miyabei Yendo on Cutibacterium acnes-Induced Skin Inflammation

Acne vulgaris is a chronic inflammatory problem of skin sebaceous hair follicles. To explore its effects on acne vulgaris, we checked out the anti-inflammatory and anti-bacterial activities of Sargassum miyabei Yendo ethanolic essence on Cutibacterium acnes -boosted inflammatory responses, both in vivo and in vitro. The levels of IL-8 and the underlying molecular results in C. acnes-stimulated HaCaT cells were examined by enzyme-linked immunosorbent assay, Western blotting, and an electrophoretic wheelchair change assay. SMYEE turned around the C. acnes-induced boost in IL-8 degrees in HaCaT cells and subdued dHL-60 cell migration. SMYEE may be a helpful treatment for C. acnes-induced acne vulgaris.

Source link: https://pubag.nal.usda.gov/catalog/7117752


Pulsed 450 nm blue light significantly inactivates Propionibacterium acnes more than continuous wave blue light

In previous studies, we showed that treatment with blue light works as an alternative to pharmaceutical intervention. As a part of our continuous initiative to boost the antimicrobial efficacy of blue light, we researched the impact of pulsed 450 nm light on P. acnes in vitro and contrasted 2 pulsed rates with continual wave irradiation. We irradiated societies of P. acnes at different irradiances and glowing powers either alone or repeatedly at different time periods, using published micro-LEDs, with the goal of finding the most affordable combination of irradiance and glowing energy that would generate 100% bacterial suppression. Our results show that treatment with 33% pulsed light offered the most effective outcome contrasted to 20% pulsed wave or constant wave. Timing irradiation to accompany the duplication cycle of P. acnes produced a substantially much better antimicrobial impact.

Source link: https://pubag.nal.usda.gov/catalog/6767738

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions